Results 71 to 80 of about 1,078,585 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cutting performance of diamond-like carbon coated tips in ultrasonic osteotomy

Journal of Dental Sciences, 2014
Background/purpose: Ultrasonic osteotomy has been introduced in oral and maxillofacial surgery in recent years for minimally invasive treatment. The purpose of this study is to evaluate the cutting performance of three different coated tips by the ...
Yunn-Shiuan Liao, Ting-Chang Lin, Cheng-Yu Lai, Yen-Liang Chen, Hao-Hueng Chang, Chun-Pin Lin   +5 more
doaj   +1 more source

Ant colony optimisation and local search for bin-packing and cutting stock problems [PDF]

, 2003
The Bin Packing Problem and the Cutting Stock Problem are two related classes of NP-hard combinatorial optimization problems. Exact solution methods can only be used for very small instances, so for real-world problems, we have to rely on heuristic ...
Bauer A, Bilchev G, Bonabeau E, Coffman EG, Dorigo M, Falkenauer E, Gambardella L, Hinterding R, Leguizamon G, Martello S, Michel R, Stützle T, Winston WL   +12 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Optimal submerged waterjet for gas recovery based on Arbitrary Lagrange‐Euler

Energy Science & Engineering, 2019
This paper proposes a coupled model of waterjet cutting coal containing gas with the Arbitrary Lagrange‐Euler algorithm assistance. The dynamic evolution of coal damage and the cutting performance under different jet conditions, including jet pattern ...
Long Wang, Zhaofeng Wang, Hai Liu, Jinsheng Chen, Tenglong Yang   +4 more
doaj   +1 more source

Study on the Engineering Technology of the Structural Design of the Index-able Turning Tool

Journal of Harbin University of Science and Technology, 2017
The optimal geometry of the working part of the cutting tool has an important influence on aspects such as high quality parts processing，improvement of production efficiency and the longer tool life in the cutting process.
HE Geng-huang, LI Ling-xiang, ZOU Ling-li, CHENG Cheng, LIU Xian-li   +4 more
doaj   +1 more source

Surface profile prediction and analysis applied to turning process [PDF]

, 2008
An approach for the prediction of surface profile in turning process using Radial Basis Function (RBF) neural networks is presented. The input parameters of the RBF networks are cutting speed, depth of cut and feed rate.
COSTES, Jean-Philippe, LU, Chen
core   +6 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source