Results 111 to 120 of about 7,476,610 (346)

Determination of cutting temperature while milling titanium alloy by face mills [PDF]

, 2016
В роботі наведений аналіз особливостей процесу високошвидкісного різання, яке головним чином пов'язують з температурою різання в залежності від швидкості обробки.
Orobchenko, A., Seredenko, B., Zabolotniy, O., Заболотній, О. А., Оробченко, А. П., Середенко, Богдан Миколайович   +5 more
core   +1 more source

Simulation on cutting forces and cutting temperature in broaching of 300M steel

Thermal Science, 2019
In this paper, using the method of single factor experiment, set the test parameters of 300M steel through AdvantEdge software broaching process simulation test, simulation results for the finishing, analyzed the influence of broach rake angle and relief
Changming Zhang, A. Mu, Qi Shen, Hui Zhang   +3 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Определение зависимости температуры резанья от режимов резания и угла скрещивания при чистовом точении валов чашечными принудительно вращающимися резцами [PDF]

, 2012
Подобран наиболее приемлемый метод определения температуры в зоне резания. Это метод термопар. Установлена зависимость изменения температуры в зоне резания от режимов резания и угла скрещивания инструмента и заготовки. Приведенные протоколы зависимостей,
Мелконов, Л. Д.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

TEMPERATURE EVALUATION UNDER CURVED-EDGE TOOL CUTTING

Advanced Engineering Research, 2014
A theoretical model for determining temperature on the working surfaces of the tool with the blade shaped profile is considered. Analytical dependences for estimating the thermal state of the blade front face (tooth cutter) with an elliptical profile in ...
Anatoly Andreyevich Ryzhkin, Denis Vitalyevich Moiseyev   +1 more
doaj   +1 more source

Analysis and prediction of residual stresses based on cutting temperature and cutting force in rough turning of Ti-6Al-4V. [PDF]

Heliyon, 2022
Li G, Lu W, Huang S, Zhang X, Ding S.
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Investigation of the effects of machining parameters on cutting conditions during orthogonal turning of austenite stainless steel

Production Engineering Archives
The 1.4306 austenite stainless steel has been prominently utilized as a material in the automotive and aerospace industry. Considerable interest has been garnered in the machinability of stainless steel owing to its high strength and poor thermal ...
Kónya Gábor, Takács János, Miskolczi István, Kovács Zsolt F.   +3 more
doaj   +2 more sources