Results 51 to 60 of about 5,467 (160)

Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency

JCI Insight
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary antibody deficiency. For unclear reasons, inflammatory complications, like gastrointestinal (GI) disease, occur in ~50% of CVID cases, worsening morbidity and mortality ...
Kevin M. Hayes, Kai Boldt, Peter J. Schnorr, Pushpinder Bawa, Miranda L. Abyazi, Matthew S. Ware, Gavin Gyimesi, Marianne James, Huaibin M. Ko, Charlotte Cunningham-Rundles, Joseph P. Mizgerd, Gustavo Mostoslavsky, Darrell N. Kotton, Paul J. Maglione   +13 more
doaj   +1 more source

A Broad Spectrum of Liver Manifestations in Common Variable Immunodeficiency Syndrome—Two Case Reports and a Literature Overview

Diagnostics
Background and Clinical Significance: Common variable immunodeficiency (CVID) is a primary B-cell immunodeficiency disorder, characterized by severe hypogammaglobulinemia and disturbed antibody production.
Eva Supovec, Jan Drnovšek
doaj   +1 more source

IgD⁺IgM⁻ B Cells in Common Variable Immunodeficiency

Pathogens
Common variable immunodeficiency (CVID) is the most frequent form of primary hypogammaglobulinemia in adults. In addition to recurrent infections and respiratory manifestations, CVID patients may present several non-infection complications such as ...
Taissa de M. Kasahara, Sudhir Gupta
doaj   +1 more source

CXCL13 as a Biomarker of Complex Common Variable Immunodeficiency

Journal of Human Immunity
Common variable immunodeficiency (CVID) is a group of heterogeneous disorders with common denominators of impaired antibody production and function and recurrent infections. Currently, prognostic biomarkers for CVID are limited.
Ioasaf Karafotias, Helene Martini, Charlotte V. Lee, Terrence T.J. Hunter, Padmalal Gurugama, Mary Guckian, Rachael Steven, Stephen Jolles, Mark Peakman, David Fear, Mohammad A.A. Ibrahim   +10 more
doaj   +1 more source

The Profile of Toll-like Receptor 2 (TLR2), TLR4 and Their Cytosolic Downstream Signaling Pathway in Common Variable Immunodeficiency (CVID) Patients

Iranian Journal of Allergy, Asthma and Immunology, 2018
Common variable immunodeficiency (CVID) is the most common clinical primary antibody deficiency, characterized by increased susceptibility to recurrent bacterial infections.
Laleh Sharifi, Asghar Aghamohammadi, Nima Rezaei, Reza Yazdani, Mahdi Mahmoudi, Mohammad Mehdi Amiri, Farimah Masoumi, Saied Bokaie, Parsova Tavasolian, Rouzbeh Sanaei, Mona Moshiri, Naeimeh Tavakolinia, Tina Alinia, Gholamreza Azizi, Abbas Mirshafiey   +14 more
doaj  

Spirometry in the management of CVID [PDF]

Journal of Allergy and Clinical Immunology, 2017
Jack G. Ghably, Harry W. Schroeder
openaire   +1 more source

Genetics and clinical phenotypes in common variable immunodeficiency

Frontiers in Genetics
Common variable immunodeficiency (CVID) is one of the most common symptomatic groups of inborn errors of immunity. In addition to infections resulting from insufficient levels of immune globulins and antibodies, many patients develop inflammatory or ...
Charlotte Cunningham-Rundles, Charlotte Cunningham-Rundles, Charlotte Cunningham-Rundles, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Bertrand Boisson, Bertrand Boisson, Bertrand Boisson   +10 more
doaj   +1 more source

Monogenic Common Variable Immunodeficiency (Mo‐CVID) Score for Optimizing the Genetic Diagnosis in Pediatric CVID Cohort

European Journal of Immunology
ABSTRACT Common variable immunodeficiency (CVID) represents an “umbrella” diagnosis due to its clinical and immunological heterogeneity. The primary objective of this study was to describe a cohort of CVID pediatric subjects from clinical, immunological, and genetic viewpoints.
Barbati, Federica, Lodi, Lorenzo, Boscia, Silvia, Cortimiglia, Martina, Calistri, Elisa, Quaranta, Francesca, Maggi, Laura, Mazzoni, Alessio, Palterer, Boaz, Annunziato, Francesco, Azzari, Chiara, Ricci, Silvia   +11 more
openaire   +2 more sources

Interstitial lung diseases (ILD) in common variable immunodeficiency (CVID) patients: a study from Iran

BMC Immunology
Introduction Interstitial lung disease (ILD) is a prevalent complication in patients with common variable immunodeficiency (CVID) and is often related to other characteristics such as bronchiectasis and autoimmunity.
Ghamartaj Khanbabaee, Fatemeh khazaii, Zahra Chavoshzadeh, Mahsa Rekabi, Zahra Ghomi, Vahide Zeinali, Matin Pourghasem, Maedeh Soflaee, Mahsa Ghadrdan   +8 more
doaj   +1 more source

Exploring gastric cancer genetics: A turning point in common variable immunodeficiency

Journal of Allergy and Clinical Immunology: Global
Background: Gastric cancer (GC) stands as a prominent cause of cancer-related mortality and ranks second among the most frequently diagnosed malignancies in individuals with common variable immunodeficiency (CVID).
Silvia Sánchez-Ramón, MD, PhD, Jesús Fuentes-Antrás, MD, Nicholas L. Rider, MD, Pedro Pérez-Segura, MD, PhD, Eduardo de la Fuente-Muñoz, MD, Miguel Fernández-Arquero, PhD, Esmeralda Neves, MD, Rebeca Pérez de Diego, PhD, Alberto Ocaña, MD, PhD, Kissy Guevara-Hoyer, MD, PhD   +9 more
doaj   +1 more source