Results 121 to 130 of about 34,737 (208)

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies [PDF]

, 2009
The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs, Ejrnaes, Mette, Herrath, Matthias G. von   +2 more
core  

Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell‐of‐origin model for osteoid osteoma and osteoblastoma

The Journal of Pathology, Volume 268, Issue 3, Page 263-275, March 2026.
Abstract Osteoid osteoma and osteoblastoma are non‐malignant bone‐forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in osteoid osteoma and osteoblastoma.
Suk Wai Lam, Tatiana Belova, Natasja Franceschini, Brendy van den Akker, David GP van IJzendoorn, Harald MM Mikkers, Hailiang Mei, Anne‐Marie Cleton‐Jansen, Marieke L Kuijjer, Karoly Szuhai, Judith VMG Bovée   +10 more
wiley   +1 more source

Pro-inflammatory cytokines and CXC chemokines as game-changer in age-associated prostate cancer and ovarian cancer: Insights from preclinical and clinical studies' outcomes

Pharmacological Research
Prostate cancer (PC) and Ovarian cancer (OC) are two of the most common types of cancer that affect the reproductive systems of older men and women. These cancers are associated with a poor quality of life among the aged population.
Amin Ullah, Yongxiu Chen, Rajeev K. Singla, Dan Cao, Bairong Shen   +4 more
doaj   +1 more source

Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis

The Journal of Dermatology, Volume 53, Issue 3, Page 372-379, March 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by barrier dysfunction, immune dysregulation, and microbial dysbiosis. Recent studies have highlighted the multifaceted roles of antimicrobial peptides (AMPs) both as innate defenders against microbial invasion and as regulators of immune responses and skin barrier ...
Ge Peng, Alafate Abudouwanli, Quan Sun, Yi Tan, Wanchen Zhao, Mengyao Yang, Shan Wang, Hideoki Ogawa, Ko Okumura, François Niyonsaba   +9 more
wiley   +1 more source

Comparison Between Phenotypic Profile and Functional Aspects of IL‐9‐Producing Lymphocytes, Th17 and Tfh of Individuals From Endemic and Non‐Endemic Areas for Hookworm Infection

Parasite Immunology, Volume 48, Issue 3, March 2026.
ABSTRACT Hookworm infections remain a major public health concern in endemic areas, modulating both the adaptive and innate immune systems. While the type 2 response is well‐characterised, the roles of T follicular helper (Tfh), Th17, and IL‐9‐producing lymphocytes remain poorly defined.
Yvanna Louise Di Christine Oliveira, Marcelo Eduardo Cardozo, Luisa Mourão Dias Magalhães, Carlos Thailan de Jesus Santos, Ramayana Morais de Medeiros Brito, Luciana Maria de Oliveira, Ana Carolina Amado Gomes, Vinícius Torres Castro Campos, Ricardo Toshio Fujiwara, Silvio Santana Dolabella, Lilian Lacerda Bueno   +10 more
wiley   +1 more source

Chemokines and Their Role in Parasitic Diseases

European Journal of Inflammation, 2004
Chemotactic cytokines (chemokines), the intercellular mediators, produced and released by a wide variety of cell types, are a group of small secreted proteins (8–10 KDa), which mediate host response to invading organisms (viruses, bacteria, parasites ...
S. Frydas, E. Karagouni, E. Papadopoulos, M. Hatzistilianou, S. Pappas, N. Papaioannou   +5 more
doaj   +1 more source

A narrative review: CXC chemokines influence immune surveillance in obesity and obesity-related diseases: Type 2 diabetes and nonalcoholic fatty liver disease. [PDF]

Rev Endocr Metab Disord, 2023
Ullah A, Ud Din A, Ding W, Shi Z, Pervaz S, Shen B.   +5 more
europepmc   +1 more source

Comprehensive analysis of the prognosis and immune infiltration for CXC chemokines in colorectal cancer. [PDF]

Aging (Albany NY), 2021
Yang X, Wei Y, Sheng F, Xu Y, Liu J, Gao L, Yang J, Sun X, Huang J, Guo Q.   +9 more
europepmc   +1 more source

CXC chemokine receptor type 5 may induce trophoblast dysfunction and participate in the processes of unexplained missed abortion, wherein p-ERK and interleukin-6 may be involved

Heliyon
Chemokines regulate the trophoblast dysfunction involved in the occurrence and development of pathological pregnancy, including missed abortions. In particular, CXC chemokine receptor type 5 mediates cell proliferation, migration, and inflammation ...
Yanan Zhi, Pingping Zhang, Yan Luo, Yanmei Sun, Juan Li, Mingming Zhang, Yali Li   +6 more
doaj   +1 more source