Results 181 to 190 of about 34,737 (208)

NOVEL CHICKEN CXC AND CC CHEMOKINES

Cytokine, 2000
Upon stimulation with lipopolysaccharide (LPS) the chicken macrophage cell line HD-11 secretes factors with cytokine activity. To characterize these molecules, representational difference analysis with RNA of LPS-induced and uninduced HD-11 cells was performed.
Sick, Christine, Schneider, Kirsten, Stäheli, Peter, Weining, Kirsten C.   +3 more
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CXC chemokines in angiogenesis of cancer

Seminars in Cancer Biology, 2004
The CXC chemokine family are unique cytokines known for their ability to have dual functions in the regulation of angiogenesis related to the following: (1) the presence or absence of the structural/functional motif (Glutamic acid-Leucine-Arginine; 'ELR' motif) that immediately precedes the first cysteine amino acid residue in the primary structure of ...
Robert M, Strieter, John A, Belperio, Roderick J, Phillips, Michael P, Keane   +3 more
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ELR+ CXC chemokines in human milk

Cytokine, 2003
CXC chemokines bearing the glutamic acid-leucine-arginine (ELR) motif are crucial mediators in neutrophil-dependent acute inflammation. Interestingly, however, Interleukin (IL)-8/CXC ligand (CXCL) 8 is expressed in human milk in biologically significant concentrations, and may play a local maturational role in the developing human intestine.
Akhil, Maheshwari, Robert D, Christensen, Darlene A, Calhoun   +2 more
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Constitutively Active Chemokine CXC Receptors

2014
Chemokines are low-molecular-weight, secreted proteins that act as leukocyte-specific chemoattractants. The chemokine family has more than 40 members. Based on the position of two conserved cysteines in the N-terminal domain, chemokines can be divided into the CXC, C, CC, and CX3C subfamilies. The interaction of chemokines with their receptors mediates
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Chemokine CXC Receptor 4: An Evolutionary Approach

Immunopharmacology and Immunotoxicology, 2006
Selected segments of the nucleotide sequences of the human 18S rRNA and the human formyl peptide receptor 1 mRNA exhibit structural similarities that are unlikely to be due simply to chance. Herein we analyze the structural similarities between the human 18S rRNA gene and the vertebrate chemokine CXC receptor 4 (CXCR4) gene that encodes a class A ...
SISTO, MARGHERITA, PANARO, Maria Antonietta, LISI, SABRINA, ACQUAFREDDA A, MAFFIONE AB, MITOLO V.   +5 more
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Cancer CXC chemokine networks and tumour angiogenesis

European Journal of Cancer, 2006
Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis.
Robert M, Strieter, Marie D, Burdick, Javier, Mestas, Brigitte, Gomperts, Michael P, Keane, John A, Belperio   +5 more
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The role of CXC chemokine ligand 4/CXC chemokine receptor 3-B in breast cancer progression

Biotechnic & Histochemistry, 2018
Chemokines and their receptors participate in the development of cancers by enhancing tumor cell proliferation, angiogenesis, invasion, metastasis and penetration of tumor immune cells. It remains unclear whether CXC chemokine ligand 4 (CXCL4)/CXC chemokine receptor 3-B (CXCR3-B) can be used as an independent molecular marker for establishing prognosis
R O, Saahene, J, Wang, M-L, Wang, E, Agbo, H, Song   +4 more
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CXC Chemokines Suppress Proliferation of Myeloid Progenitor Cells by Activation of the CXC Chemokine Receptor 2

The Journal of Immunology, 1998
Abstract IL-8 is one of the major mediators of the transendothelial migration of neutrophils from the circulation to the site of injury and infection. In this work we demonstrate that the CXC or α-chemokines, IL-8 and melanoma growth stimulatory activity (MGSA) induce myeloid suppression via direct action on progenitor cells, mediated by
X, Sanchez, K, Suetomi, B, Cousins-Hodges, J K, Horton, J, Navarro   +4 more
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CXC Chemokines in Cancer Angiogenesis

2009
Chemokines were first described for their ability to recruit leukocytes, but their biological role has now been recognized in many other biological processes. Angiogenesis, or the process of new blood vessel growth, is critical to many physiologic and pathologic processes, including tumorigenesis.
B. Mehrad, R. M. Strieter
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CXC Chemokines in Angiogenesis Related to Pulmonary Fibrosis

Chest, 2002
Angiogenesis, defined as the growth of new capillaries from preexisting vessels, is a pervasive biological phenomenon that is at the core of many physiologic and pathologic processes. An opposing balance of angiogenic and angiostatic factors regulates angiogenesis.
Robert M, Strieter, John A, Belperio, Michael P, Keane   +2 more
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