Results 171 to 180 of about 19,999 (211)
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Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS
Trends in Immunology, 2003The mammalian CXC chemokine system comprises 16 ligands and six receptors, and its actions stretch well beyond the immune system. Recent elucidation of the pufferfish genome, a representative of an evolutionary ancient vertebrate class, has enabled analysis of the mammalian CXC chemokine system in a phylogenetic context.
Huising, M.O. +4 more
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2022
Chemokines are a family of small, chemoattractant cytokines that play a central role in regulating the migration of cells into inflamed tissue. The CXC-chemokine sub-family is characterized by four cysteine amino acids that form two pairs of disulfide bridges, with the two cysteines proximal to the N-terminus separated by an additional amino acid (CXC).
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Chemokines are a family of small, chemoattractant cytokines that play a central role in regulating the migration of cells into inflamed tissue. The CXC-chemokine sub-family is characterized by four cysteine amino acids that form two pairs of disulfide bridges, with the two cysteines proximal to the N-terminus separated by an additional amino acid (CXC).
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NOVEL CHICKEN CXC AND CC CHEMOKINES
Cytokine, 2000Upon stimulation with lipopolysaccharide (LPS) the chicken macrophage cell line HD-11 secretes factors with cytokine activity. To characterize these molecules, representational difference analysis with RNA of LPS-induced and uninduced HD-11 cells was performed.
Sick, Christine +3 more
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THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS
Shock, 1995The regulation of angiogenesis is fundamental to a variety of physiological and pathological processes. Although a number of factors have been identified that induce neovascularization, it is becoming increasingly apparent that endogenous angiostatic factors may play an important role in the regulation of angiogenesis during wound repair, chronic ...
R M, Strieter +3 more
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The role of CXC chemokines and their receptors in cancer
Cancer Letters, 2008Chemokines, or chemotactic cytokines, and their receptors have been discovered as essential and selective mediators in leukocyte migration to inflammatory sites and to secondary lymphoid organs. Besides their functions in the immune system, they also play a critical role in tumor initiation, promotion and progression.
Jo, Vandercappellen +2 more
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ELR+ CXC chemokines in human milk
Cytokine, 2003CXC chemokines bearing the glutamic acid-leucine-arginine (ELR) motif are crucial mediators in neutrophil-dependent acute inflammation. Interestingly, however, Interleukin (IL)-8/CXC ligand (CXCL) 8 is expressed in human milk in biologically significant concentrations, and may play a local maturational role in the developing human intestine.
Akhil, Maheshwari +2 more
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The Journal of Immunology, 1998
Abstract IL-8 is one of the major mediators of the transendothelial migration of neutrophils from the circulation to the site of injury and infection. In this work we demonstrate that the CXC or α-chemokines, IL-8 and melanoma growth stimulatory activity (MGSA) induce myeloid suppression via direct action on progenitor cells, mediated by
X, Sanchez +4 more
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Abstract IL-8 is one of the major mediators of the transendothelial migration of neutrophils from the circulation to the site of injury and infection. In this work we demonstrate that the CXC or α-chemokines, IL-8 and melanoma growth stimulatory activity (MGSA) induce myeloid suppression via direct action on progenitor cells, mediated by
X, Sanchez +4 more
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CXC Chemokines in Angiogenesis Related to Pulmonary Fibrosis
Chest, 2002Angiogenesis, defined as the growth of new capillaries from preexisting vessels, is a pervasive biological phenomenon that is at the core of many physiologic and pathologic processes. An opposing balance of angiogenic and angiostatic factors regulates angiogenesis.
Robert M, Strieter +2 more
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The Role of CXC Chemokines in the Regulation of Tumor Angiogenesis
Cancer Investigation, 2001Sérgio Dias, Shahin Rafii
exaly +3 more sources
2005
Publisher Summary This chapter reviews the role that CXC chemokines play in mediating various events that are important and relevant to cancer. CXC chemokines can enhance innate and adaptive immunity, regulate angiogenesis, and mediate tumor‐cell metastases.
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Publisher Summary This chapter reviews the role that CXC chemokines play in mediating various events that are important and relevant to cancer. CXC chemokines can enhance innate and adaptive immunity, regulate angiogenesis, and mediate tumor‐cell metastases.
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