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CXC chemokines in angiogenesis [PDF]
Cytokine and Growth Factor Reviews, 2005 CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis.
Brigitte Gomperts +2 more
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Developmental and Comparative Immunology, 2013 In this study, we have identified 421 molecules across the vertebrate spectrum and propose a unified nomenclature for CXC chemokines in fish, amphibians and reptiles based on phylogenetic analysis.
Christopher John Secombes +2 more
exaly +2 more sources
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CXC chemokines in angiogenesis of cancer
Seminars in Cancer Biology, 2004The CXC chemokine family are unique cytokines known for their ability to have dual functions in the regulation of angiogenesis related to the following: (1) the presence or absence of the structural/functional motif (Glutamic acid-Leucine-Arginine; 'ELR' motif) that immediately precedes the first cysteine amino acid residue in the primary structure of ...
John A Belperio +2 more
exaly +3 more sources
Three novel carp CXC chemokines are expressed early in ontogeny and at nonimmune sites
FEBS Journal, 2004 Three novel CXC chemokines were identified in common carp (Cyprinus carpio L.) through homology cloning. Phylogenetic analyses show that one of the three CXC chemokines is an unambiguous orthologue of CXCL14, whereas both others are orthologues of CXCL12,
Gert Flik +2 more
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Pharmacology & Therapeutics, 2006
ELR+ CXC chemokines, by direct interaction with their cell surface receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2), are believed to be crucially involved in the direct migration and activation of leukocytes. ELR+ CXC chemokines are supposed to play a key role in several inflammatory diseases and this makes ELR+ CXC ...
Andrea R Beccari +2 more
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ELR+ CXC chemokines, by direct interaction with their cell surface receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2), are believed to be crucially involved in the direct migration and activation of leukocytes. ELR+ CXC chemokines are supposed to play a key role in several inflammatory diseases and this makes ELR+ CXC ...
Andrea R Beccari +2 more
exaly +3 more sources
Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS
Trends in Immunology, 2003The mammalian CXC chemokine system comprises 16 ligands and six receptors, and its actions stretch well beyond the immune system. Recent elucidation of the pufferfish genome, a representative of an evolutionary ancient vertebrate class, has enabled analysis of the mammalian CXC chemokine system in a phylogenetic context.
Huising, M.O. +4 more
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The role of CXC chemokines and their receptors in cancer
Cancer Letters, 2008Chemokines, or chemotactic cytokines, and their receptors have been discovered as essential and selective mediators in leukocyte migration to inflammatory sites and to secondary lymphoid organs. Besides their functions in the immune system, they also play a critical role in tumor initiation, promotion and progression.
Jo, Vandercappellen +2 more
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2022
Chemokines are a family of small, chemoattractant cytokines that play a central role in regulating the migration of cells into inflamed tissue. The CXC-chemokine sub-family is characterized by four cysteine amino acids that form two pairs of disulfide bridges, with the two cysteines proximal to the N-terminus separated by an additional amino acid (CXC).
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Chemokines are a family of small, chemoattractant cytokines that play a central role in regulating the migration of cells into inflamed tissue. The CXC-chemokine sub-family is characterized by four cysteine amino acids that form two pairs of disulfide bridges, with the two cysteines proximal to the N-terminus separated by an additional amino acid (CXC).
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THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS
Shock, 1995The regulation of angiogenesis is fundamental to a variety of physiological and pathological processes. Although a number of factors have been identified that induce neovascularization, it is becoming increasingly apparent that endogenous angiostatic factors may play an important role in the regulation of angiogenesis during wound repair, chronic ...
R M, Strieter +3 more
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