Results 181 to 190 of about 19,999 (211)

The role of CXC chemokine ligand 4/CXC chemokine receptor 3-B in breast cancer progression

Biotechnic & Histochemistry, 2018
Chemokines and their receptors participate in the development of cancers by enhancing tumor cell proliferation, angiogenesis, invasion, metastasis and penetration of tumor immune cells. It remains unclear whether CXC chemokine ligand 4 (CXCL4)/CXC chemokine receptor 3-B (CXCR3-B) can be used as an independent molecular marker for establishing prognosis
R O, Saahene, J, Wang, M-L, Wang, E, Agbo, H, Song   +4 more
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CXC Chemokines in Cancer Angiogenesis

2009
Chemokines were first described for their ability to recruit leukocytes, but their biological role has now been recognized in many other biological processes. Angiogenesis, or the process of new blood vessel growth, is critical to many physiologic and pathologic processes, including tumorigenesis.
B. Mehrad, R. M. Strieter
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The Emerging Role of CXC Chemokines And Their Receptors in Cancer

Future Medicinal Chemistry, 2012
Chemokines and their receptors have a multifaceted role in tumor biology and are implicated in nearly all aspects of cancer growth, survival and dissemination. Modulation of the interaction between chemokines and their cell surface receptor is, therefore, a promising area for the development of new cancer medicines.
Victoria, Vinader, Kamyar, Afarinkia
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Assignment of the mouse and cow CXC chemokine genes

Cytogenetic and Genome Research, 1998
Gene specific PCR primers were constructed for five mouse and three bovine CXC chemokine genes. The mouse genes were assigned using SSCP analyses of the Jackson BSS backcross panel to two groups on chromosome 5. One group containing <i>Gro1</i> and <i>Mip2</i> cosegregated with reference markers <i>Alb1</i> and <i&
W S, Modi, M R, Amarante, M, Hanson, J E, Womack, A, Chidambaram   +4 more
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CXC Chemokines in Angiogenesis Relevant to Chronic Fibroproliferation

Current Drug Target -Inflammation & Allergy, 2005
The CXC chemokines are an unique family of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The mechanisms for the different activity in regulating angiogenesis by members of this chemokine family is related to the following: 1) the presence or absence of the structural/functional motif (Glutamic acid-
Robert M, Strieter, John A, Belperio, Marie D, Burdick, Michael P, Keane   +3 more
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Cancer CXC chemokine networks and tumour angiogenesis

European Journal of Cancer, 2006
Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis.
Robert M, Strieter, Marie D, Burdick, Javier, Mestas, Brigitte, Gomperts, Michael P, Keane, John A, Belperio   +5 more
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Chemokine CXC Receptor 4: An Evolutionary Approach

Immunopharmacology and Immunotoxicology, 2006
Selected segments of the nucleotide sequences of the human 18S rRNA and the human formyl peptide receptor 1 mRNA exhibit structural similarities that are unlikely to be due simply to chance. Herein we analyze the structural similarities between the human 18S rRNA gene and the vertebrate chemokine CXC receptor 4 (CXCR4) gene that encodes a class A ...
SISTO, MARGHERITA, PANARO, Maria Antonietta, LISI, SABRINA, ACQUAFREDDA A, MAFFIONE AB, MITOLO V.   +5 more
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Constitutively Active Chemokine CXC Receptors

2014
Chemokines are low-molecular-weight, secreted proteins that act as leukocyte-specific chemoattractants. The chemokine family has more than 40 members. Based on the position of two conserved cysteines in the N-terminal domain, chemokines can be divided into the CXC, C, CC, and CX3C subfamilies. The interaction of chemokines with their receptors mediates
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CXC chemokines and angiogenesis/angiostasis.

Proceedings of the Association of American Physicians, 1999
Angiogenesis is important to a variety of physiological and pathological processes. While a variety of factors have been determined to regulate angiogenesis, members of the CXC chemokine family can either promote or inhibit this process. This disparity in biological behavior is due to the presence or absence of a structural-functional domain--three ...
M P, Keane, D A, Arenberg, B B, Moore, C L, Addison, R M, Strieter   +4 more
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Chemokines with CXC motif and their receptors in neuroendocrine neoplasms

Endocrine-Related Cancer
Neuroendocrine neoplasms (NENs) are challenging rare neoplasms not only for diagnosis but also for management. Immunotherapy has become a promising approach for NENs and clinical trials in phase I–II have been undertaken to evaluate the safety and efficacy of this treatment strategy.
Karolina Merecz, Pawel Hikisz, Aleksandra Tarasiuk-Zawadzka, Jakub Fichna, Damian Jacenik   +4 more
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