Results 31 to 40 of about 62,416 (259)

Cryo-thermal therapy inducing MI macrophage polarization created CXCL10 and IL-6-rich pro-inflammatory environment for CD4+ T cell-mediated anti-tumor immunity

International Journal of Hyperthermia, 2019
Purpose: We previously developed a novel cryo-thermal therapy to treat malignant mammary carcinoma and melanoma in a mouse model; long-term survival and CD4+ T cell orchestrating anti-tumor immune memory response were achieved.
Ping Liu, Shengguo Jia, Yue Lou, Kun He, Lisa X. Xu   +4 more
doaj   +1 more source

Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C? [PDF]

Journal of Immunology Research, 2019
Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and “chronic hepatitis C virus (HCV) infection” (CHC). Here, we review the scientific literature about HCV and CXCL10. The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B can identify patients with acute ...
Ferrari S. M., Fallahi P., Ruffilli I., Elia G., Ragusa F., Paparo S. R., Patrizio A., Mazzi V., Colaci M., Giuggioli D., Ferri C., Antonelli A.   +11 more
openaire   +5 more sources

Association of circulating CXCL10 and CXCL11 with systemic sclerosis [PDF]

Annals of the Rheumatic Diseases, 2018
Systemic sclerosis (SSc) is an autoimmune disorder defined ‘vascular’ disease1 due to early defective angiogenesis ending in severe multiorgan fibrosis.2 Biomarker(s) mirroring early microvascular derangements in SSc,3 potentially useful for very early diagnosis, are lacking. C-X-C angiostatic chemokines induced by interferon-γ, like CXCL10 and CXCL11,
Crescioli, Clara, Corinaldesi, Clarissa, Riccieri, Valeria, Raparelli, Valeria, Vasile, Massimiliano, Del Galdo, Francesco, Valesini, Guido, Lenzi, Andrea, Basili, Stefania, Antinozzi, Cristina   +9 more
openaire   +5 more sources

CXCL10 and CXCR3 in the Trigeminal Ganglion Contribute to Trigeminal Neuropathic Pain in Mice

Journal of Pain Research, 2021
Yuan-Yuan Ju,1,2 Ming Jiang,2 Feifei Xu,1,3 Dongqin Wang,1,3 Bixiao Ding,1,3 Ling-Jie Ma,2 Hao Wu1 1Department of Otolaryngology, Head, and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China ...
Ju YY, Jiang M, Xu F, Wang D, Ding B, Ma LJ, Wu H   +6 more
doaj  

Effectivity Of Annona Muricata and Artemisinin Combined Therapy on Brain CXCL10 expression (Study in Swiss Mice During Severe Plasmodium Berghei ANKA Infection)

Journal of Biomedicine and Translational Research, 2019
Background: Malaria, caused by Plasmodium sp infection, is a major global cause of morbidity and mortality. Most experimental cerebral malaria (ECM) studies show increase number of Th1 cells and CTLs in the brain, due to increase chemokine expression ...
Abdulhakim Sulayman, Kis - Djamiatun, Muflihatul Muniroh   +2 more
doaj   +1 more source

Involvement of CXCL10 in Neuronal Damage under the Condition of Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1

Journal of Integrative Neuroscience, 2023
Objective: Few studies have reported the direct effect of C–X–C motif chemokine ligand 10 (CXCL10) and Neuregulin 1 (Nrg1) on neurons after spinal cord injury (SCI). This study reports the role of CXCL10 in the regulation of neuronal damage after SCI and
Xin-yu Qiao, Yi Wang, Wei Zhang, Qian Li, Chong Liu, Ji-ji Dao, Chen-meng Qiao, Chun Cui, Yan-qin Shen, Wei-jiang Zhao   +9 more
doaj   +1 more source

CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis [PDF]

Respiratory Research, 2005
Abstract Background Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by repeated inhalations of finely dispersed organic particles or low molecular weight chemicals. The disease is characterized by an alveolitis sustained by CD8(+) cytotoxic T lymphocytes, granuloma formation, and,
CALABRESE, FIORELLA, AGOSTINI, CARLO, Poletti V, REA, FEDERICO, FACCO, MONICA, MIORIN, MARTA, CABRELLE, ANNA, ZAMBELLO, RENATO, TRENTIN, LIVIO, SEMENZATO, GIANPIETRO CARLO, VALENTE, MARIALUISA   +10 more
openaire   +6 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

CXCL10 Is Associated with Increased Cerebrospinal Fluid Immune Cell Infiltration and Disease Duration in Multiple Sclerosis

Biomolecules, 2023
Background: Cerebrospinal fluid (CSF) is an important sampling site for putative biomarkers and contains immune cells. CXCL10 is a multiple sclerosis (MS)-relevant chemokine that is present in the injured central nervous system and recruits CXCR3+ immune
Stephanie N. Blandford, Neva J. Fudge, Craig S. Moore   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source