Results 21 to 30 of about 62,416 (259)

CXCL10-based gene cluster model serves as a potential diagnostic biomarker for premature ovarian failure [PDF]

PeerJ, 2023
Objective Premature ovarian failure (POF) is a disease with high clinical heterogeneity. Subsequently, its diagnosis is challenging. CXCL10 which is a small signaling protein involved in immune response and inflammation may have diagnostic potential in ...
Ying Qin, Canliang Wen, Huijiao Wu
doaj   +2 more sources

CXCL10Expression in Human Colorectal Cancer Tissue and its Correlation With Serum Levels of CXCL10

Cancer Genomics - Proteomics, 2023
CXCL10, a member of the CXC chemokine family, plays a crucial role in immune response by facilitating the chemotaxis of CXCR3-positive immune cells. We examined the expression of CXCL10 to unravel its functional significance in colorectal cancer.Bioinformatics analysis was performed to investigate CXCL10 expression and its clinicopathological relevance.
Lianbo, Li, Kosuke, Kanemitsu, Koji, Ohnishi, Rin, Yamada, Hiromu, Yano, Yukio, Fujiwara, Yuji, Miyamoto, Yoshiki, Mikami, Taizo, Hibi, Hideo, Baba, Yoshihiro, Komohara   +10 more
openaire   +2 more sources

Expression of CXCL10 in cultured cortical neurons [PDF]

Journal of Neurochemistry, 2010
J. Neurochem. (2010) 112, 703–714.AbstractChemokines expressed in neurons are important mediators in neuron‐neuron and neuron‐glia signaling. One of these chemokines is CCL21 that activates microglia via the chemokine receptor CXCR3. As neurons also express CXCL10, a main ligand for CXCR3, we have thus investigated in detail the expression pattern of ...
VINET, JONATHAN, de Jong, Eiko K, Boddeke, Hendrikus W. G. M, Stanulovic, Vesna, Brouwer, Nieske, Granic, Ivica, Eisel, Ulrich L. M, Liem, Robert S. B, Biber, Knut   +8 more
openaire   +6 more sources

A Teleost CXCL10 Is Both an Immunoregulator and an Antimicrobial

Frontiers in Immunology, 2022
Chemokines are a group of cytokines that play important roles in cell migration, inflammation, and immune defense. In this study, we identified a CXC chemokine, CXCL10, from Japanese flounder Paralichthys olivaceus (named PoCXCL10) and investigated its immune function.
Huili Li, Huili Li, Huili Li, Yuanyuan Sun, Yuanyuan Sun, Li Sun, Li Sun, Li Sun   +7 more
openaire   +3 more sources

Role of CXCL10 in Spinal Cord Injury

International Journal of Medical Sciences, 2022
Spinal cord injury (SCI) results in acute inflammatory responses and secondary damages, including neuronal and glial cell death, axonal damage and demyelination, and blood-brain barrier (BBB) damage, eventually leading to neuronal dysfunction and other complications.
Qiao, Xinyu, Zhang, Wei, Zhao, Weijiang
openaire   +2 more sources

Resistance to Dengue Virus Infection in Mice Is Potentiated by CXCL10 and Is Independent of CXCL10-Mediated Leukocyte Recruitment [PDF]

The Journal of Immunology, 2010
Abstract CXCL10 is an IFN-inducible chemokine ligand that binds CXCR3, a receptor that is expressed on lymphocytes; CXCL10 shares the CXCR3 receptor with another two ligands, CXCL9 and CXCL11. Previously, we found that CXCL10−/− mice were more susceptible than wild-type (WT) mice to dengue virus (DENV) infection.
Peng-Peng, Ip, Fang, Liao
openaire   +6 more sources

The Multifaceted Functions of CXCL10 in Cardiovascular Disease [PDF]

BioMed Research International, 2014
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for
Borne, P. van den, Quax, P.H.A., Hoefer, I.E., Pasterkamp, G.   +3 more
openaire   +4 more sources

CXCL10- a path to β-cell death [PDF]

Islets, 2009
The ability of the β-cells to control blood glucose levels depends on their function and mass. In both, type 1 and type 2 diabetes mellitus the main processes leading to β-cell failure are apoptosis and loss of function. Many studies demonstrate how cytokines and chemokines have an active role in triggering the immune-response against the β-cell ...
Federico, Paroni, Erna, Domsgen, Kathrin, Maedler   +2 more
openaire   +2 more sources

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

OncoImmunology, 2017
Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load ...
Julian P. Layer, Marie T. Kronmüller, Thomas Quast, Debby van den Boorn-Konijnenberg, Maike Effern, Daniel Hinze, Kristina Althoff, Alexander Schramm, Frank Westermann, Martin Peifer, Gunther Hartmann, Thomas Tüting, Waldemar Kolanus, Matthias Fischer, Johannes Schulte, Michael Hölzel   +15 more
doaj   +1 more source

The emerging role of CXCL10 in cancer (Review)

Oncology Letters, 2011
The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 is involved in chemotaxis, induction of apoptosis, regulation of cell growth and mediation of angiostatic effects.
Mingli, Liu, Shanchun, Guo, Jonathan K, Stiles   +2 more
openaire   +3 more sources