Results 311 to 320 of about 76,809 (334)
Some of the next articles are maybe not open access.
The CXCR4/CXCL12 axis in endometrial cancer
Clinical & Experimental Metastasis, 2009Chemokines and their receptors seem to act as important regulators of the metastatic cascade. CXCL12 and its receptor CXCR4 were shown to be involved in human cancer progression. There is increasing evidences suggesting that the expression of CXCR4 in human cancers is correlated with poor patient prognosis and that CXCR4 neutralization can prevent ...
GELMINI, STEFANIA +9 more
openaire +3 more sources
The role of CXCL12 in tumor microenvironment
Gene, 2018The chemokine ligand C-X-C motif chemokine ligand 12 (CXCL12) is a kind of small molecules of cytokines that widely expressed in diversified tissues. Recent evidence suggests that CXCL12 plays an important role in the communication of tumor cells with their surrounding microenvironment.
Wenfang Meng, Shihang Xue, Ye Chen
openaire +2 more sources
Science Signaling, 2017
The chemokine CXCL12 released from early stage pancreatic cancer recruits Schwann cells and suppresses pain signaling.
openaire +2 more sources
The chemokine CXCL12 released from early stage pancreatic cancer recruits Schwann cells and suppresses pain signaling.
openaire +2 more sources
CXCL12-γ expression is inhibited in neuroinflammation
Brain Research, 2013CXCL12 plays a protective role in CNS autoimmunity. Expression of CXCL12-γ, which has distinct structural and functional properties than the other isoforms of CXCL12, was determined in spinal cords of rats immunized to develop experimental autoimmune encephalomyelitis (EAE).
Timotijević, Gordana S +5 more
openaire +4 more sources
CXCL12 and CXCR4 in bone marrow physiology
Expert Review of Hematology, 2010This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival or apoptosis.
Natalia M, Moll, Richard M, Ransohoff
openaire +2 more sources
Nitric oxide inhibits CXCL12 expression in neuroinflammation
Immunology & Cell Biology, 2013Chemokine CXCL12 (C‐X‐C motif chemokine ligand 12) restricts immune cell invasion of the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune encephalomyelitis (EAE), an animal model of inflammatory and demyelinating disease of the CNS, multiple sclerosis (MS). Nitric oxide (NO), by contrast, predominantly contributes to
Petković, Filip +4 more
openaire +3 more sources
Pathological roles of the homeostatic chemokine CXCL12
Cytokine & Growth Factor Reviews, 2018CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12 in general, or of a specific CXCL12 splicing variant has been demonstrated in various ...
Rik, Janssens +2 more
openaire +2 more sources
CXCR7, CXCR4 and CXCL12: An eccentric trio?
Journal of Neuroimmunology, 2008CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking.
Marcus, Thelen, Sylvia, Thelen
openaire +2 more sources
CXCL12/CXCR4 signalling in neuronal cell migration
Current Opinion in Neurobiology, 2008The chemokine CXCL12 (or SDF-1) and its receptor CXCR4 have originally been described as regulators of cell interactions in the immune system. However, over the past years it has become clear that this receptor/ligand pair is an important component of the machinery that controls cell migration in different regions of the developing nervous system. Here
Tiveron, M.C., Cremer, H.
openaire +3 more sources
CXCR4-CXCL12-Dependent Inflammatory Network and Endothelial Progenitors
Current Medicinal Chemistry, 2010The endothelial progenitor cells (EPCs) are angiogenic cells having properties similar to those of embryonal angioblasts. The number and function of EPCs are affected by a variety of conditions, including cytokines and chemokines, which are pivotal inflammatory signaling molecules. The purpose of this paper is to review current knowledge about the role
SALVATORE, PAOLA +3 more
openaire +3 more sources