Results 111 to 120 of about 34,241 (258)

Increase of circulating CXCL9 and CXCL11 associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis.

, 2011
CONTEXT:Recently, CXCL9 and CXCL11 have been shown to be involved in autoimmune thyroid disorders; however, no data are present about CXCL9 and CXCL11 circulating levels in thyroid autoimmunity.
Ferrari P, Frascerra S, Fallahi P., Ele Ferrannini, Paola Ferrari, Di Domenicantonio A, NICOLINI, ANDREA, Alessandro Antonelli, Andrea Di Domenicantonio, Silvia Frascerra, Silvia Martina Ferrari, Andrea Nicolini, ANTONELLI, ALESSANDRO, FERRANNINI, ELEUTERIO, Poupak Fallahi, Ferrari SM   +15 more
core   +1 more source

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans

, 2009
BACKGROUND & AIMS: Fibrosis is the hallmark of chronic liver diseases, yet many aspects of its mechanism remain to be defined. Chemokines are ubiquitous chemotactic molecules that mediate many acute and chronic inflammatory conditions, and CXC chemokine ...
Gaßler, Nikolaus, Dahl, Edgar, Berres, Marie-Luise, Moreno Zaldivar, Mirko, Streetz, Konrad Ludwig, Tacke, Frank, Wasmuth, Hermann E., Keppeler, Hildegard, Zimmermann, Henning, Weiskirchen, Ralf, Schmitz, Petra, Berg, Thomas, Lammert, Frank, Streetz, Konrad L., Zimmermann, Henning Wolfgang, Zaldivar, Mirko Moreno, Hillebrandt, Sonja, Trautwein, Christian, Friedman, Scott L., Scholten, David, Hellerbrand, Claus   +20 more
core   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion

Frontiers in Immunology
BackgroundThe crosstalk between macrophages and trophoblasts plays a crucial role in the development and progression of recurrent spontaneous abortion (RSA).
Sisi Yan, Xiang Wang, Qiuji Wu, Jinli Ding, Hui Qiu   +4 more
doaj   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Антибактериальные свойства хемокина CXCL9

In recent years, there has been an unprecedented increase in the resistance of bacterial strains to antibiotics. Millions of deaths per year are recorded worldwide due to the spread of antibiotic-resistant strains.
Краева Л.А., Биджиев А.З., Бургасова О.А.   +2 more
core  

Polisitemia Vera’da CXCL9-CXCR3 Sitokin Sinyal Yolağının Etkisi

, 2019
Amaç: Miyeloproliferatif Neoplaziler (MPN), miyeloproliferatif bozukluklar arasında en sık görülen hastalıklardandır. Tamamen işlevsel olan ve son aşamaya kadar farklılaşmış kan hücrelerinin aşırı üretimi ile karakterize edilirler.
Altunay, Cemil, Yavuz, Akif Selim, Sözer Tokdemir, Selçuk   +2 more
core   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

CXCL9 may serve as a potential biomarker for primary Sjögren’s syndrome with extra-glandular manifestations

Arthritis Research & Therapy
Background Primary Sjögren's syndrome (pSS) is an autoimmune condition that causes harm to exocrine glands and also has extra-glandular manifestations (EGM). pSS patients with EGM have a worse prognosis than those with only sicca symptoms.
Jingwei Hong, Hui Cheng, Ping Wang, Yanzhi Wu, Saisai Lu, Yan Zhou, Xiao bing Wang, Xiaofang Zhu   +7 more
doaj   +1 more source