Results 1 to 10 of about 22,526 (176)

Pathophysiological role of chemokine MIG/CXCL9 in the development of atopic dermatitis [PDF]

Acta Biomedica Scientifica, 2022
Background. In patients with atopic dermatitis, the persistence of microorganisms on the skin surface is high, which can enhance the expression of MIG/CXCL9, exacerbating inflammation and activating keratinocyte apoptosis, however, the dynamics of this ...
I. V. Kibalina, N. N. Tsybikov, E. V. Fefelova, L. F. Sholokhov   +3 more
doaj   +4 more sources

Generation of a Tumor-Specific Chemokine Gradient Using Oncolytic Vesicular Stomatitis Virus Encoding CXCL9 [PDF]

Molecular Therapy - Oncolytics, 2020
Genetically modified vesicular stomatitis virus (VSV) is an attractive agent for cancer treatment due to rapid intratumoral replication and observed clinical responses.
Rebecca A Nace, Jason M Tonne, Laura Evgin   +2 more
exaly   +5 more sources

CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions [PDF]

Frontiers in Immunology, 2017
Several acute and chronic inflammatory diseases are driven by accumulation of activated leukocytes due to enhanced chemokine expression. In addition to specific G protein-coupled receptor-dependent signaling, chemokine–glycosaminoglycan (GAG ...
Vincent Vanheule, Daiane Boff, Anneleen Mortier   +2 more
exaly   +5 more sources

Chemokine CXCL9, a marker of inflammaging, is associated with changes of muscle strength and mortality in older men. [PDF]

Osteoporos Int
Our study examined associations of the CXC motif chemokine ligand 9 (CXCL9), a pro-inflammatory protein implicated in age-related inflammation, with musculoskeletal function in elderly men. We found in certain outcomes both cross-sectional and longitudinal significant associations of CXCL9 with poorer musculoskeletal function and increased mortality in
Seo DH, Corr M, Patel S, Lui LY, Cauley JA, Evans D, Mau T, Lane NE.   +7 more
europepmc   +7 more sources

CXCL9 Is a Potential Biomarker of Immune Infiltration Associated With Favorable Prognosis in ER-Negative Breast Cancer [PDF]

Frontiers in Oncology, 2021
The chemokine CXCL9 (C-X-C motif chemokine ligand 9) has been reported to be required for antitumour immune responses following immune checkpoint blockade. In this study, we sought to investigate the potential value of CXCL9 according to immune responses
Chun-Fa Chen, Yuan-Ke Liang, Si-Qi Qiu   +2 more
exaly   +5 more sources

Tissue-specific regulation of CXCL9/10/11 chemokines in keratinocytes: Implications for oral inflammatory disease. [PDF]

PLoS ONE, 2017
The IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 play a key role in many inflammatory conditions, particularly those mediated by T cells.
Alison Marshall, Antonio Celentano, Nicola Cirillo, Michael McCullough, Stephen Porter   +4 more
doaj   +9 more sources

Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9. [PDF]

J Nucl Med
Noninvasive monitoring of immune responses is important for increasing the efficacy of cancer immunotherapy. Although several approaches exist, few methods directly report on T-cell activation. We aimed to develop a novel PET probe targeting C-X-C motif chemokine ligand 9 (CXCL9), a chemokine specifically induced by interferon gamma (IFN-γ), a cytokine
Jacobson O, Zhang HH, Olkowski CP, Ghaemi B, Basuli F, Shi J, Bell MM, Parween F, Ganesan S, Esparza TJ, Escorcia FE, Choyke PL, Farber JM.   +12 more
europepmc   +3 more sources

Co-delivery of chemokine CXCL9 and costimulatory ligand TNFSF9 by mesenchymal stem cells reprograms the immune microenvironment for triple-negative breast cancer [PDF]

npj Breast Cancer
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with a high risk of relapse and metastasis. Due to limited tumor immune infiltration in TNBC, the effectiveness of immunotherapy is constrained.
Pingting Ye, Yixuan Wen, Rui Liu, Weiqiang Gao, Qi Li, Bin Ma, Chunyan Dong   +6 more
doaj   +2 more sources

The chemokine CXCL9 expression is associated with better prognosis for colorectal carcinoma patients

Biomedicine and Pharmacotherapy, 2016
The chemokine CXCL9 has been demonstrated to play an important role in the development of human malignancies. However, its prognostic significance in cancer patients remains unclear and less is known about its role in colonrectal carcinoma (CRC) patients.
Zhenqian Wu, Song Yu, Zhiming Jin
exaly   +3 more sources

SAT-715 Chemokine CXCL9 level is associated with sarcopenia in older women [PDF]

J Endocr Soc
Abstract Disclosure: D. Seo: None. S. Hong: None. B. Kim: None. Background: A recent study has shown that the CXC motif chemokine ligand 9 (CXCL9), a pro-inflammatory protein implicated in age-related inflammation, is associated with poorer musculoskeletal function and increased mortality in older men.
Seo, Da Hea, Hong, Seongbin, Kim, Beom-Jun   +2 more
europepmc   +3 more sources