Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice [PDF]
Hepatology, 2012 Abstract Recent data suggest that the chemokine receptor CXCR3 is functionally involved in fibroproliferative disorders, including liver fibrosis. Neoangiogenesis is an important pathophysiological feature of liver scarring, but a functional role of angiostatic CXCR3 ...
MORENO ZALDIVAR, Mirko +16 more
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CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of chemokine-receptor signaling. [PDF]
PLoS Pathogens, 2015 Chemokines have been shown to be effective bactericidal molecules against a variety of bacteria and fungi in vitro. These direct antimicrobial effects are independent of their chemotactic activities involving immunological receptors.
Sarah A Reid-Yu +4 more
doaj +3 more sources
CXCR3 chemokine receptor ligands in sarcoidosis [PDF]
Медицинская иммунология, 2021 Sarcoidosis is a polysystemic inflammatory disease of unknown etiology, morphologically related to the group of granulomatosis, with heterogeneous clinical manifestations and outcomes.
N. M. Lazareva +7 more
doaj +3 more sources
The CXC Chemokine MIG/CXCL9 Is Important in Innate Immunity againstStreptococcus pyogenes [PDF]
The Journal of Infectious Diseases, 2007 Pharyngitis caused by Streptococcus pyogenes is one of the most common bacterial infections in humans and is also a starting point for invasive S. pyogenes infection. Here, we describe that tonsil fluid from patients with streptococcal pharyngitis contains high amounts of the interferon (IFN)-dependent CXC chemokine known as monokine induced by IFN ...
Egesten, Arne +8 more
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CXCL9-11 chemokines and CXCR3 receptor in teleost fish species [PDF]
Fish and Shellfish Immunology Reports, 2022 The coordinated migration of immune cells from lymphoid organs to in or out of the bloodstream, and towards the site of infection or tissue damage is fundamental for an efficient innate and adaptive immune response. Interestingly, an essential part of this movement is mediated by chemoattractant cytokines called chemokines.
Natalia Valdés +4 more
openaire +6 more sources
Increased Expression of CXCL9, CXCL10, and CXCL11 in Epstein–Barr Virus-Associated Infectious Mononucleosis and the Role of CXCL5 as a Candidate Biomarker of Disease Severity [PDF]
PathogensBackground: Epstein–Barr virus (EBV)-associated infectious mononucleosis (IM) elicits a robust cellular immune response; however, systemic chemokine profiles in pediatric IM and their diagnostic relevance remain insufficiently characterized.
Andrea Nikčević +5 more
doaj +2 more sources
Targeting cellular source-specific CXCL9 signaling for immunotherapy in oral squamous cell carcinoma [PDF]
Frontiers in ImmunologyOral squamous cell carcinoma (OSCC) remains a clinical challenge due to its high recurrence, metastatic potential, and limited responsiveness to current immunotherapies.
Miao Qiu +4 more
doaj +2 more sources
Diagnostic and Prognostic Potential of CXCL9 and CXCL10 Chemokines in Alcohol-Associated Liver Disease. [PDF]
Int J Mol SciAlcohol-associated liver disease (ALD) is the leading cause of liver-related mortality. In ALD, excessive inflammatory response may induce a massive loss of hepatocytes and lead to irreversible liver damage with progressive fibrosis. Chemokines stimulate the migration of immune cells to the site of inflammation and contribute to the inflammatory ...
Szczerbinska A +3 more
europepmc +3 more sources
Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10 [PDF]
PLoS Neglected Tropical Diseases, 2012 Chronic Chagas cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi. Even though the Th1 T cell-rich myocarditis plays a pivotal role in CCC pathogenesis, little is known about the factors controlling inflammatory cell migration to CCC myocardium ...
Luciana Gabriel Nogueira +19 more
openaire +5 more sources
CXCL9-expressing tumor-associated macrophages: new players in the fight against cancer [PDF]
Journal for ImmunoTherapy of Cancer, 2021 Tumor-associated macrophages (TAMs) are among the main contributors to immune suppression in the tumor microenvironment, however, TAM depletion strategies have yielded little clinical benefit.
Shahram Salek-Ardakani +2 more
doaj +2 more sources