Results 121 to 130 of about 34,241 (258)

Decidual macrophage‐mediated ferroptosis in trophoblasts leads to recurrent spontaneous abortion

iMeta, EarlyView.
Decidual macrophages from recurrent spontaneous abortion (RSA) patients promote trophoblast ferroptosis and impair trophoblast cell function. Mechanistically, the CXCL2/NF‐κB/HMOX1 axis mediates this effect. Conversely, trophoblasts co‐cultured with RSA decidual macrophages induce pro‐inflammatory macrophage polarization through IL‐6/JAK2/STAT3 ...
Xin Chen, Xueqin Ma, Pengcheng Pang, Heng Zhou, Ruohan Li, Yan He, Yan Zhang, Jing Yang, Qianlin Song, Qingsong Ye   +9 more
wiley   +1 more source

Association between CXCL9 and CXCL10 chemokine gene polymorphisms and acute graft rejection after liver transplantation

, 2019
Akutno stanično odbacivanje (ASO) klinički je vrlo značajan događaj koji ugrožava preživljenje i presatka i primatelja jetre. Kemokini CXCL9/10 imaju ključnu ulogu u regrutiranju T-limfocita u presadak te su njihove povišene serumske vrijednosti povezane
Ostojić, Ana
core   +2 more sources

Abstract P2-06-22: The Modulation of CXCL9 Release by Prostaglandin E2 and Cyclooxygenase Inhibitors in Human Breast Cancer

, 2010
Introduction IFN γ inducible chemokine CXCL9 impairs tumor growth and metastasis formation through recruitment of natural killer (NK) cells and tumor suppressive T lymphocytes in murine breast cancer models.
H Bronger, S Kräft, A Welk, M Kiechle, M Schmitt, U. Schwarz-Boeger, A Stöckel   +6 more
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Antigen-specific chemokine profiles as biomarkers for detecting Mycobacterium tuberculosis infection

Frontiers in Immunology
BackgroundLatent tuberculosis (TB) infection can progress to active TB, which perpetuates community transmission that undermines global TB control efforts.
Weicong Ren, Zichun Ma, Qiang Li, Rongmei Liu, Liping Ma, Cong Yao, Yuanyuan Shang, Xuxia Zhang, Mengqiu Gao, Shanshan Li, Yu Pang   +10 more
doaj   +1 more source

The safe and effective use of tofacitinib and ustekinumab combination therapy in infantile onset inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Infantile‐onset inflammatory bowel disease (IOIBD) is a rare and severe subset of very‐early‐onset IBD, often associated with immune dysregulation and poor response to conventional therapies. Data regarding the use of Janus kinase inhibitors (JAKI) in this population is limited.
Smridhi Mahajan, Christian Wysocki, Bhaskar Gurram   +2 more
wiley   +1 more source

Cxcl9-deficiency attenuates the progression of post-traumatic osteoarthritis in mice

Inflammation Research
Abstract Objective Osteoarthritis (OA) is one of the leading causes of disability in the aging population. While about 10% of the adult population is affected by OA, there is to date no curative treatment and joint replacement surgery remains the only option for treating end-stage OA.
Donat, Antonia, Xie, Weixin, Jiang, Shan, Brylka, Laura Janina, Schinke, Thorsten, Rolvien, Tim, Frosch, Karl-Heinz, Baranowsky, Anke, Keller, Johannes   +8 more
openaire   +2 more sources

Nail Lichen Planus in Children ‐ Epidemiology, Pathogenesis, Clinical Presentation, and Treatment

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail lichen planus (NLP) is a chronic inflammatory disorder that, while rare in children compared to adults, represents a significant cause of pediatric nail dystrophy that requires early recognition to prevent permanent scarring and nail loss.
Francesca Pampaloni, Matilde Iorizzo
wiley   +1 more source