Results 161 to 170 of about 34,241 (258)

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Tumor-microenvironment-modulating microspheres to augment tumor-infiltrating lymphocyte therapy against solid tumors. [PDF]

Cell Rep Med
Li M, Yan S, Yan X, Nie Z, Wang H, Li Q, Liu H, Yu W, Zhang S, Liu Y, Chen H, Wu WD, Chao Y, Liu Z.   +13 more
europepmc   +1 more source

CXCL9 associates with experimental neuromyelitis optica spectrum disorder following adoptive transfer of Tfh and Th17 cells. [PDF]

Front Immunol
Wang L, Zhou L, Huang W, ZhangBao J, Tan H, Fan Y, Lu C, Yu J, Wang M, Lu J, Zhao C, Wang J, Quan C.   +12 more
europepmc   +1 more source

Tocilizumab for severe and refractory mucous membrane pemphigoid

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Elevated IL‐6 levels identified in mucous membrane pemphigoid support IL‐6 blockade, with tocilizumab demonstrating clinical benefit in nine patients with severe and refractory mucous membrane pemphigoid. Abstract Background Mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease involving mucous membranes with a potentially ...
Billal Tedbirt, Maud Maho‐Vaillant, Julie Gueudry, Marie‐Laure Golinski, Marion Marcaillou, Blanche Bergeret, Guillaume Chambon, Pierre Bouchetemble, Soumeya Bekri, Abdellah Tebani, Hervé Maillard, Cécile Morice, Anais Vautier, Edgar‐Pierre Libert, Christelle Le Roux‐Villet, Marion Carrette, Olivier Boyer, Vivien Hébert, Sébastien Calbo, André Gillibert, Pascal Joly   +20 more
wiley   +1 more source

A Tumor-Promoting Inflammatory SPP1+ Macrophage-IL6-CRP Axis Drives Immune Dysfunction in Bladder Cancer. [PDF]

Cancer Discov
Tran MA, Cho BA, Izadmehr S, Yoo SK, Youssef D, Anker JF, Farkas AM, Figueiredo I, Lee K, Ananthanarayanan A, Balan S, Onkar S, Banchereau R, Gupta S, Chhibber A, Wang L, Beaumont KG, Li Z, Garcia-Barros M, Bicak M, Cordon-Cardo C, Brody R, Kim-Schulze S, Yuen K, Mariathasan S, Atiq SO, Adeyelu TT, Elliott A, Barata P, McKay RR, Gnjatic S, Gonzalez-Kozlova E, Mehrazin R, Horowitz A, Sfakianos JP, Chowell D, Galsky MD, Bhardwaj N.   +37 more
europepmc   +1 more source

Active learning-guided mechanistic modeling of CXCL9 regulation in pancreatic cancer

Cold tumors like pancreatic cancer suffer from poor immune infiltration, limiting effective anti-tumor responses. The chemokine CXCL9 promotes immune cell recruitment, but the signaling mechanisms regulating its expression in tumor cells remain poorly ...
Yelleswarapu, V.S.M.K., Wang, B.; id_orcid, Descamps, L., Eduati, F.   +3 more
core   +1 more source

Macrophage Phenotype Alterations in Treated Periodontitis Patients Suggest a Pro‐Inflammatory Bias

Journal of Periodontal Research, EarlyView.
Monocyte‐derived macrophages from successfully treated stage III periodontitis patients show a persistent skewing toward an M1‐like pro‐inflammatory phenotype across polarization conditions, suggesting that immune dysregulation may persist despite clinical periodontal stability.
Mariane Cristina Sloniak, Josiane Betim de Assis, Luciana Saraiva, Cláudio Mendes Pannuti, Ana Paula Lepique, Cristina Cunha Villar   +5 more
wiley   +1 more source

Hyperglycemia aggravates vitiligo through succinate/SUCNR1-mediated T cell activation. [PDF]

J Clin Invest
Kang P, Chang Y, Wang T, Yi X, Wang Y, Du P, Chen J, Li B, Li S, Shao Z, Chen J, Li C.   +11 more
europepmc   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Molecular basis of CXC chemokine receptor 3 ligand multispecificity. [PDF]

Sci Adv
Bouyssou A, Sun D, Zhou T, Smith S, Ho H, Johnson M, Azumaya C, Noreng S, Liu P, Ti S, Joshi P, Tam C, Yang Y, Janezic E, Comps-Agrar L, Masureel M.   +15 more
europepmc   +1 more source