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Amplification of the CXCR3/CXCL9 axis via intratumoral electroporation of plasmid CXCL9 synergizes with plasmid IL-12 therapy to elicit robust anti-tumor immunity [PDF]
Molecular Therapy - Oncolytics, 2022 Clinical studies have demonstrated that local expression of the cytokine IL-12 drives interferon-gamma expression and recruits T cells to the tumor microenvironment, ultimately yielding durable systemic T cell responses.
Jack Y Lee +2 more
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Microparticle-delivered Cxcl9 prolongs Braf inhibitor efficacy in melanoma
Cancer Immunology Research, 2022ABSTRACT Patients with BRAF-mutant melanoma show significant responses to combined BRAF and MEK inhibition, but most relapse within 2 years. A major reservoir for drug resistance is minimal residual disease (MRD), comprised of drug-tolerant tumor cells laying in a dormant state.
Gabriele Romano +13 more
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The Multifaceted Roles of CXCL9 Within the Tumor Microenvironment
2020Chemokines are soluble proteins that orchestrate cell migration in a regulated concentration gradient. During early stages of tumor development, chemokines shape the immune landscape of tumor microenvironment. CXCL9, also known as monokine induced by gamma-interferon (MIG), can be produced during inflammatory conditions by myeloid cells within the ...
Shi Yong, Neo, Andreas, Lundqvist
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Journal of Clinical Medicine, 2019 The chemokines CXCL9 and CCL20 have been reported to be associated with ventricular dysfunction. This study was aimed to investigate the effects of CXCL9/CCL20 on cardiac fibrosis following myocardial infarction (MI).
Shui-Tein Chen +2 more
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Association of a CXCL9 polymorphism with pediatric Crohn’s disease
Biochemical and Biophysical Research Communications, 2007Genetic and environmental factors contribute to the etiopathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). To identify new susceptibility genes, we determined the mRNA expression level of 88 genes from different biological contexts on colonic biopsies of CD and UC patients. We show that CXCL9 was overexpressed in colonic tissue of 3/5 CD
Martin, Lacher +5 more
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CXCL9 and CXCL10 gene polymorphisms in patients with rheumatoid arthritis
Rheumatology International, 2015Chemokines (CXCL) and their receptors play important roles in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the CXCL9 (rs3733236 G>A) and CXCL10 (rs8878 A>G) genes and RA. We examined 422 RA patients and 338 subjects as a control group. Single nucleotide polymorphisms (SNPs)
Daniel, Kotrych +4 more
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Regulation of CXCL9/10/11 in Oral Keratinocytes and Fibroblasts
Journal of Dental Research, 2008Th1 and Th2 cytokines such as interferon-γ (IFN-γ ) , tumor necrosis factor- α (TNF-α ), and IL-4 are expressed in T-cell-mediated inflammation in the oral cavity. We tested the hypothesis that those cytokines may act on CXCR3-agonistic chemokines, T-cell recruiting factors, and on neighboring cells, including oral keratinocytes and fibroblasts.
K, Ohta +6 more
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CXCL9 chemokine in ulcerative colitis.
La Clinica terapeutica, 2019The aim of this narrative review is to highlight the role of CXCL9 in Ulcerative Colitis (UC), in order to understand the mechanism underlying the inflammation in UC and to investigate also if Th1-chemokines could be useful as a marker of disease. It was shown that chemokine (C-X-C motif) receptor (CXCR)3 and its ligand chemokine, monokine induced by ...
G, Elia, G, Guglielmi
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ANTIBACTERIAL PROPERTIES OF THE CHEMOKINE CXCL9
Vrach, 2022A. Bidzhiev, L. Kraeva, O. Burgasova
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