The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B
Frontiers in Immunology, 2022 The chemokine receptor CXCR3 plays a critical role in immune cell recruitment and activation. CXCR3 exists as two main isoforms, CXCR3-A and CXCR3-B, resulting from alternative splicing.
Nathan Reynders +2 more
exaly +3 more sources
CXCR3 ameliorates neutrophil-dependent disease severity in SARS-CoV-2 infection by regulating CD4+ T cell recruitment [PDF]
Frontiers in ImmunologyUnderstanding the host immune response to SARS-CoV-2 infection is critical for developing effective immunotherapeutic interventions. Using bulk RNA sequencing of lung tissue from mock-infected and mouse-adapted SARS-CoV-2 strain MA-10-infected mice, we ...
Md Jashim Uddin +16 more
doaj +2 more sources
Ovarian hormones and high-fat diet duration distinctively modulate hypothalamic chemokine profile. [PDF]
J NeuroendocrinolAbstract Excessive intake of saturated fats triggers inflammation in the hypothalamus, a key regulator of energy balance. In the chronic phase of this inflammatory response, bone marrow‐derived and lymphoid cells are chemoattracted to this region, partially mitigating high‐fat diet (HFD)‐induced metabolic impairments.
Augusto AGB +8 more
europepmc +2 more sources
PD-1/PD-L1-CXCR3 Coexpression and CXCR3 on Intermediate Monocytes Predict Fibrosis, Leukemic Transformation, and Survival in Egyptian Philadelphia-Negative Myeloproliferative Neoplasms [PDF]
Clinical Medicine Insights: OncologyBackground: Despite established prognostic scores, predicting disease progression in myeloproliferative neoplasms (MPNs) remains challenging, and the role of specific immune cell subsets—particularly the PD-1/PD-L1 axis—in mediating fibrosis and ...
Dalia E Sherief +5 more
doaj +2 more sources
The Role of CXCR3 and Its Chemokine Ligands in Skin Disease and Cancer
Frontiers in Medicine, 2018 Chemokines and their receptors play an important role in the recruitment, activation and differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9, CXCL10, and CXCL11 are key immune chemoattractants during interferon-induced ...
Zhen Zeng +2 more
exaly +3 more sources
CXCR3 gene as a therapeutic target in colorectal cancer [PDF]
BMC CancerBackground Cancers, especially colorectal cancer, are among the most common and deadly diseases in the world, and their incidence is increasing in various countries.
Seyedeh Zohreh Azarshin +3 more
doaj +2 more sources
Indian Dermatology Online Journal, 2023 Introduction: Basal cell carcinoma (BCC) is the most common type of skin cancer worldwide. The pathogenesis of BCC involves interplay between various environmental and genetic factors.
Mariya K Ansari +4 more
doaj +1 more source
miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2 [PDF]
Genetics and Molecular Biology, 2021 MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investigated the potential biological effects of miR-34a and its target CXCR3 in phenotypic modulation of ...
Xuesong Yuan +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B cells.
Alessandra Noto +17 more
doaj +1 more source
Cell Death and Disease, 2023 Glioblastoma (GBM) is a highly aggressive brain tumor associated with limited therapeutic options and a poor prognosis. CXCR3, a chemokine receptor, serves dual autocrine–paracrine functions in cancer.
Travis Yui Hei Chan +4 more
doaj +1 more source