Results 31 to 40 of about 28,744 (150)

CXCL10 can inhibit endothelial cell proliferation independently of CXCR3. [PDF]

PLoS ONE, 2010
CXCL10 (or Interferon-inducible protein of 10 kDa, IP-10) is an interferon-inducible chemokine with potent chemotactic activity on activated effector T cells and other leukocytes expressing its high affinity G protein-coupled receptor CXCR3.
Gabriele S V Campanella, Richard A Colvin, Andrew D Luster   +2 more
doaj   +1 more source

SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals

Signal Transduction and Targeted Therapy, 2023
Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (TFH) cells.
Rongzhang He, Xingyu Zheng, Jian Zhang, Bo Liu, Qijie Wang, Qian Wu, Ziyan Liu, Fangfang Chang, Yabin Hu, Ting Xie, Yongchen Liu, Jun Chen, Jing Yang, Shishan Teng, Rui Lu, Dong Pan, You Wang, Liting Peng, Weijin Huang, Velislava Terzieva, Wenpei Liu, Youchun Wang, Yi-Ping Li, Xiaowang Qu   +23 more
doaj   +1 more source

CHEMOKINE RECEPTORS AT DISTINCT DIFFERENTIATION STAGES OF T-HELPERS FROM PERIPHERAL BLOOD

Медицинская иммунология, 2016
Expression of chemokine receptors (CCR4, CCR6, CXCR3 and CXCR5) on T-helper (Th) cells at various levels of differentiation in a group of healthy volunteers (n = 52) was assessed on the basis of CD45RA and CD62L expression, using the eight-color flow ...
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebriakova, Areg A. Totolian   +5 more
doaj   +1 more source

CXCR3 Inhibition Blocks the NF-κB Signaling Pathway by Elevating Autophagy to Ameliorate Lipopolysaccharide-Induced Intestinal Dysfunction in Mice

Cells, 2023
Autophagy is a cellular catabolic process in the evolutionarily conservative turnover of intracellular substances in eukaryotes, which is involved in both immune homeostasis and injury repairment.
Cheng Zhang, Yian Deng, Yingsi Zhang, Tongtong Ba, Sai Niu, Yiqin Chen, Yuan Gao, Hanchuan Dai   +7 more
doaj   +1 more source

A Comparative Study of the Effects of Nine CXCR3 Antagonists on Macrophage Function and the Treatment of Acute Lung Injury

Frontiers in Bioscience-Landmark
Background: The C-X-C motif chemokine receptor 3 (CXCR3) antagonist AMG 487 has been shown to alleviate acute lung injury (ALI) in mice.
Mengjie Zhang, Ziyu Wan, Zefeng Zhu, Pengbin Wang, Xuan Xu, Tianhao Ma, Feng Qian, Lexing Li, Guoquan Liu, Wei Gu   +9 more
doaj   +1 more source

Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer

Cell Communication and Signaling, 2019
Background Carcinoma cells shift between epithelial and mesenchymal phenotypes during cancer progression, as defined by surface presentation of the cell-cell cohesion molecule E-cadherin, affecting dissemination, progression and therapy responsiveness ...
Bo Ma, Ahmad Khazali, Hanshuang Shao, Yuhan Jiang, Alan Wells   +4 more
doaj   +1 more source

The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C.

PLoS ONE, 2012
BackgroundIn mouse models, natural killer (NK) cells have been shown to exert anti-fibrotic activity via killing of activated hepatic stellate cells (HSC). Chemokines and chemokine receptors critically modulate hepatic recruitment of NK cells.
Marianne Eisenhardt, Andreas Glässner, Benjamin Krämer, Christian Körner, Bernhard Sibbing, Pavlos Kokordelis, Hans Dieter Nischalke, Tilman Sauerbruch, Ulrich Spengler, Jacob Nattermann   +9 more
doaj   +1 more source

Plasmodium chabaudi AS Infection Induces CD4+ Th1 Cells and Foxp3+T-bet+ Regulatory T Cells That Express CXCR3 and Migrate to CXCR3 Ligands

Frontiers in Immunology, 2019
Control and elimination of blood-stage Plasmodium chabaudi AS infection requires CD4+ Th1 cells that secrete IFN-γ and T follicular help (Tfh) cells together with B cell production of antibody.
Floriana Berretta, Floriana Berretta, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Mary M. Stevenson, Mary M. Stevenson   +6 more
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Peripheral blood B-cells and CXCR3 expression in chronic hepatitis C virus infection

Инфекция и иммунитет
Hepatitis C virus (HCV) infection remains a serious global healthcare challenge, often leading to chronic disease with complications such as liver cirrhosis, hepatocellular carcinoma, and extrahepatic manifestations.
Natalia A. Arsentieva, Dmitrii S. Elezov, Igor V. Kudryavtsev, Zoya R. Korobova, Areg A. Totolian   +4 more
doaj   +1 more source