Results 121 to 130 of about 94,110 (297)

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Mechanistic study of novel arylpiperazine derivative NAF19 in prostate cancer treatment based on network pharmacology approach

Romanian Journal of Laboratory Medicine
Our preliminary studies identified the arylpiperazine derivative NAF19 as a promising therapeutic agent against prostate cancer, though its precise mechanisms remained unclear.
Jiang Hua, Xu Mingzhen, Jiang Songsong, Huang Weiqiang, Chen Hong   +4 more
doaj   +1 more source

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

, 2015
Chao Xu,1,* Hong Zhao,1,* Haitao Chen,1 Qinghua Yao2,3 1First Clinical College of Zhejiang Chinese Medical University, 2Department of Integrated Traditional Chinese and Western Medicine, Zhejiang Cancer Hospital, 3Key Laboratory of Integrated ...
Xu C, Chen H, Yao Q, Zhao H
core  

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

M1 macrophage-derived CXCL12 drives neurogenic heterotopic ossification following spinal cord injury

Neural Regeneration Research
Patients with spinal cord injury frequently develop neurogenic heterotopic ossification, whose pathogenesis remains incompletely understood. Existing research models struggle to accurately simulate the complex pathological process.
Yulei Xie, Yaomin Luo, Xin Chen, Yinxu Wang, Wei Song, Hua Ling   +5 more
doaj   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Silencing of CXCR4 Inhibits Tumor Cell Proliferation and Neural Invasion in Human Hilar Cholangiocarcinoma

Gut and Liver, 2014
Background/AimsTo evaluate the expression of CXC motif chemokine receptor 4 (CXCR4) in the tissues of patients with hilar cholangiocarcinoma (hilar-CCA) and to investigate the cell proliferation and frequency of neural invasion (NI) influenced by RNAi ...
doaj   +1 more source

CXCR4-Targeted Macrophage-Derived Biomimetic Hybrid Vesicle Nanoplatform for Enhanced Cancer Therapy through Codelivery of Manganese and Doxorubicin

Immune-cell-derived membranes have garnered significant attention as innovative delivery modalities in cancer immunotherapy for their intrinsic immune-modulating functionalities and superior biocompatibilities.
Yujin Kim (483088), Yeonwoo Jang (17624073), Young Seok Cho (2901023), Ziye Wan (18226935), James J. Moon (204208), Hansoo Park (437998), Xingwu Zhou (7485593), April Kim (4708795)   +7 more
core   +1 more source

Representative PDAC cases with different EGFR/CXCR4 expression profiles: EGFR-/CXCR4− (A), EGFR+/CXCR4− (B), EGFR-/CXCR4+ (C), and EGFR+/CXCR4+ (D). Magnification x 100.

, 2015
Representative PDAC cases with different EGFR/CXCR4 expression profiles: EGFR-/CXCR4− (A), EGFR+/CXCR4− (B), EGFR-/CXCR4+ (C), and EGFR+/CXCR4+ (D). Magnification x 100.
Huanwen Wu (697595), Liang Zhu (172992), Huadan Xue (487099), Wenze Wang (586963), Xiaohua Shi (697596), Li Zhang (8200), Hui Zhang (7197), Zhiyong Liang (580570)   +7 more
core   +1 more source