Results 141 to 150 of about 94,110 (297)
Clinical Pharmacology &Therapeutics, EarlyView.Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović +11 more
wiley +1 more source
Emerging concept of cancer as a stem cell disorder
Open Life Sciences, 2006 Ratajczak Mariusz +5 more
doaj +1 more source
Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles
, 2012 Ugutz Unzueta,1–3 María Virtudes Céspedes,3,4 Neus Ferrer-Miralles,1–3 Isolda Casanova,3,4 Juan Cedano,5 José Luis Corchero,1–3 Joan Domingo-Espín,1–3 Antonio Villaverde ...
Corchero JL +9 more
core
iMetaMed, EarlyView.A pan‐cancer atlas deciphers tumor‐induced reprogramming in bone metastases. Malignant evolution toward MYC/proliferation is a hallmark of bone metastases. Niche‐mediated immune dysfunction is characterized by immature pDCs, impaired antigen presentation and phagocytosis in TAMs, and exhausted T cells.
Yitong Pan +4 more
wiley +1 more source
Detection of CXCR4 transcript in extracellular vesicles released from cultured Schwann cells
reservedIl sistema nervoso periferico è dotato della proprietà di rigenerare in modo più o meno completo in seguito a danni di diversa natura (fisica, chimica o biologica), al contrario del sistema nervoso centrale.
CELEGATO, ELISA DORA
core
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Optimization of a synthetic siRNA delivery for the treatment of rhabdomyosarcoma
Open Life Sciences, 2008 Lesko Ewa +4 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou +3 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.This article explores the potential of 3D‐printed, cell‐free implants or devices for cartilage regeneration. It highlights the benefits of using biomaterial‐driven activation and modulation of ESCPs for endogenous healing of heterogeneous tissues, addressing challenges in implant design, repair mechanisms, and regulatory hurdles to create scalable ...
Liangbin Zhou +11 more
wiley +1 more source