Results 161 to 170 of about 88,749 (308)

Detection of CXCR4 transcript in extracellular vesicles released from cultured Schwann cells

reservedIl sistema nervoso periferico è dotato della proprietà di rigenerare in modo più o meno completo in seguito a danni di diversa natura (fisica, chimica o biologica), al contrario del sistema nervoso centrale.
CELEGATO, ELISA DORA
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CXCR4 antagonist AMD3100 elicits analgesic effect and restores the GlyRα3 expression against neuropathic pain

, 2017
Xiaoming Liu, Hongjun Liu, Lihua Dai, Bingjie Ma, Ke Ma Pain Management Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Objective: Chemokine CXCL12 and its ...
Liu X, Liu H, Dai L, Ma K, Ma BJ
core  

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Cellular tropism of HIV-1 mediated and contrained by coreceptor dependencies

, 2005
The ability of cells to migrate to specific sites is critical for the proper functioning of both innate and adaptive immune responses in primates. This selective responsiveness is largely orchestrated by small proteins known as chemokines, which direct ...
Nolan, D., Gaudieri, S., Lucas, A.D., Rauch, A., Mallal, S.   +4 more
core  

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

The association of CXCR4 expression with clinicopathological significance and potential drug target in prostate cancer: a meta-analysis and literature review

, 2015
Qi Chen, Tie Zhong Department of Urology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xian, Shaanxi Province, People’s Republic of China Abstract: CXCR4/CXCL12 axis plays an important role in tumor growth, angiogenesis ...
Chen Q, Zhong T
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Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer

, 2015
Changyuan Zhang,1,* Jie Li,2,* Yi Han,3 Jian Jiang4 1Department of Cardiothoracic Surgery, Inner Mongolia Autonomous Region People’s Hospital, Inner Mongolia; 2Department of Oncology, 3Department of Thoracic Surgery, Beijing Chest Hospital ...
Jiang J, Li J, Han Y, Zhang C
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Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association.

, 2008
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro.
Pedro L. Vera, Katherine L Meyer-Siegler, Kenneth A. Iczkowski, Katherine L. Meyer-Siegler, Kenneth A Iczkowski, Iczkowski Kenneth A., Wang Xihai, Pedro L Vera, Xihai Wang, Vera Pedro L., Meyer-Siegler Katherine L.   +10 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source