Results 161 to 170 of about 94,110 (297)

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Primary Aldosteronism Subtype Diagnosis: Adrenal Venous Sampling vs. CXCR4 PET CT. [PDF]

Endocrinol Diabetes Metab
Liu S, Zhang Y, Liu X, Zhou H, Shen S, Yin N, Zhu Y.   +6 more
europepmc   +1 more source

The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models

International audienceIntroduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an overactive immune response, particularly involving excessive production of type I interferons.
Korganow, Anne-Sophie, Grinberg, Séverine, Gies, Vincent, Soulas-Sprauel, Pauline, Herbeuval, Jean Philippe, Bekaddour, Nassima, Giorgiutti, Stéphane, Rodeschini, Vincent, Duffy, Darragh, Smith, Nikaïa, Caspar, Birgit, Dupuy, Stephanie, Nisole, Sébastien, Leboulanger, Nicolas   +13 more
core   +1 more source

CCL5 and GLUT1 define leader cells in collective invasion of colorectal cancer

The Journal of Pathology, EarlyView.
Abstract Invasion and metastasis in multiple solid tumors are promoted by collective invasion which is organized by leader and follower cells. Yet in colorectal cancer (CRC), biomarkers and mechanisms that specify leader cells remain undefined. Here we identify biomarkers of leader cells and elucidate how they drive CRC collective invasion and ...
Zhaowen Zhang, Jiaying Tan, Zhicheng Zeng, Xiaohui Zhu, Liyao Mai, Yao Yin, Yuting Huang, Wei Kang, Honghui Jiang, Shaowan Xu, Yanqing Ding, Xinghua Pan, Feifei Wang, Li Liang   +13 more
wiley   +1 more source

Investigating the Link Between Specific Signaling Molecules (CCL5, CCR5, CXCR4, BMPR2) and Cardiac Health Indicators in Rheumatoid Arthritis Individuals: A Cross-Sectional Study. [PDF]

Health Sci Rep
Hassan NH, Khoobbakht F, Shamsi A, Roghani SA, Assar S, Pournazari M, Taghadosi M.   +6 more
europepmc   +1 more source

Transcriptional Profiling of Growth Hormone-Secreting Pituitary Adenoma Stem-Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications. [PDF]

MedComm (2020)
Yuan L, Yang H, Li B, Sui H, Li P, Wang X, Li J, Jia G, Zhu Z, Li D, Jia W, Kang P.   +11 more
europepmc   +1 more source

CXCR4 Inhibitor [PDF]

, 2020
openaire   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Role of CXCR4 PET Imaging for the Evaluation of Gliomas: A Comprehensive Literature Review. [PDF]

Cancers (Basel)
Dondi F, Bellini P, Cossandi M, Rinaldi R, Camoni L, Tomasoni F, Statuto M, Viganò GL, Bertagna F.   +8 more
europepmc   +1 more source

Hitting the right spot on CXCR4 [PDF]

Nature Reviews Rheumatology, 2019
Mchugh, Jessica, Herbeuval, Jean-Philippe, Smith, Nikaia   +2 more
openaire   +3 more sources