Results 161 to 170 of about 38,937 (354)
Advanced Science, EarlyView.Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao +13 more
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Advanced Science, EarlyView.This work proposed a synergistic cation‐anion solvation engineering strategy for wide‐temperature and high‐voltage electrolytes. The superior ionic conductivity under subzero temperatures, excellent thermal stability, and induced inorganic‐rich cathode‐electrolyte interphase endow the LiCoO2 cathodes reliable performance under harsh conditions with a ...
Hao Zhang +8 more
wiley +1 more source
Note on the results of cooling certain hydrated platin-cyanides in liquid air
, 1909 James Reynolds
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Effect of cyanide on the biosynthesis of ascorbic acid by an enzyme preparation from goat-liver tissue [PDF]
, 1958 I. B. Chatterjee +3 more
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Advanced Science, EarlyView.⁻Inspired by the “brick wall” structure of pearl layer, FLICE‐110% liquid‐free ionic conductive elastomer had high mechanical strength (5.46 MPa), excellent ionic conductivity (3.29 × 10−4 S cm−1) and resilience. It can be used in smart music boxes, airplane wings and control manipulators.
Zequan Li +13 more
wiley +1 more source
Advanced Science, EarlyView.The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang +7 more
wiley +1 more source
The conversion of cyanogen chloride to cyanide in the presence of blood proteins and sulphydryl compounds [PDF]
, 1951 W. N. Aldridge
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Advanced Science, EarlyView.We designed a copper‐based nanotube (NT) with copper ionophores to induce enhanced cuproptosis. In combination with starvation therapy, the NT significantly inhibited energy metabolism in HCC cells. Our results show that the depletion of GSH by Cu2+ intensified oxidative stress and cuproptosis, resulting in ROS generation and DLAT aggregation ...
Xuan Han +8 more
wiley +1 more source
Nature CommunicationsDirect and site-selective C-H functionalization of alkenes under environmentally benign conditions represents a useful and attractive yet challenging transformation to access value-added molecules.
Ming-Shang Liu +4 more
doaj +1 more source