Results 41 to 50 of about 40,160 (316)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

ЭКОЛОГИЧЕСКИ БЕЗОПАСНЫЙ РЕАГЕНТ ДЛЯ ОБЕЗВРЕЖИВАНИЯ И ОЧИСТКИ РАСТВОРОВ, СОДЕРЖАЩИХ ЦИАНИДЫ

Cifra: Химия
Реагенты на основе ферратов щелочных металлов предназначены для обезвреживания и очистки сточных вод, содержащих соли циановодородной кислоты и ацидокомплексы цветных и благородных металлов.
Смирнов С.В., Киселева Г.В., Первова И.Г.   +2 more
doaj   +1 more source

Development of a method for measuring mass concentration of cyanides in soil samples using gas chromatography and tandem mass-selective detection

Вестник войск РХБ защиты, 2020
The Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction places CN-containing toxic chemicals like tabun and its numerous homologues and analogues (around 10.000 organic compounds),
D. O. Korneev, M. A. Ponsov, A. A. Rodionov, L. V. Petrakova, I. V. Rybalchenko   +4 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

EFFECTS OF DRYING AND ENSILING METHODS ON CYANIDES CONTENTS AND CHEMICAL COMPONENTS OF CASSAVA ROOTS AND STEMS [PDF]

, 2008
The objectives of this experiment was to compare the drying and ensiling methods to reduce cyanides contents in cassava, as well as related nutrient components.
Achmadi, Joelal, Kawamoto, Y, Mizumachi, S, Purnomoadi, A, Rahmi, B, Yanti, Y   +5 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The spectroscopic parameters of sodium cyanide, NaCN (X 1A'), revisited

, 2019
The study of the rotational spectrum of NaCN (X $^1$A') has recently been extended in frequency and in quantum numbers. Difficulties have been encountered in fitting the transition frequencies within experimental uncertainties.
Cohen, D.T. Halfen, Halfen, He, Holger S.P. Müller, Kawaguchi, L.M. Ziurys, Müller, Müller, Müller, Müller, Müller, Pickett, Turner, van Vaals, van Vaals   +15 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Possibilities of correcting iatrogenic mucositis with cyanides in experiment

Russian Open Medical Journal, 2020
Background — Radiation and chemotherapy of cancer cause complications that drastically reduce the quality of life. This requires the search for effective therapeutic agents for the mucositis treatment.
Kristina A. Arakelyan, Inessa G. Romanenko, Elena P. Golubinskaya, Evgeniya Yu. Zyablitskaya, Tatyana P. Makalish   +4 more
doaj   +1 more source

A geometrical model for Mixed cyanide crystals

, 1999
A model of diluted random field sustained by quenched volume deformations is shown to reproduce puzzling physical features found in X(CN)_{x}Y_{1-x} mixed cyanide crystals. X is an alkali metal (K, Na or Rb) and Y is a spherical halogen ion (Br, Cl or I).
Aharony, Andelman, Binder, Galam, Galam, Galam, Galam, Galam, Galam, Henriques, Hessinger, Höchli, Kaufman, Knorr, Kwiecien, Loidl, Mattis, Serge Galam   +17 more
core   +1 more source