Results 31 to 40 of about 65,630 (160)

Endogenous Parathyroid Hormone Promotes Fracture Healing by Increasing Expression of BMPR2 through cAMP/PKA/CREB Pathway in Mice

Cellular Physiology and Biochemistry, 2017
Background/Aims: Endogenous parathyroid hormone (PTH) plays an important role in fracture healing. This study investigated whether endogenous PTH regulates fracture healing by bone morphogenetic protein (BMP) and/or the transforming growth factor-β (TGF ...
Wei Zhou, Lipeng Yu, Jin Fan, Bowen Wan, Tao Jiang, Jian Yin, Yao Huang, Qingqing Li, Guoyong Yin, Zhaoxing Hu   +9 more
doaj   +1 more source

CDPKs: The critical decoders of calcium signal at various stages of malaria parasite development

Computational and Structural Biotechnology Journal, 2021
Calcium ions are used as important signals during various physiological processes. In malaria parasites, Plasmodium spp., calcium dependent protein kinases (CDPKs) have acquired the unique ability to sense and transduce calcium signals at various ...
Manish Sharma, Himashree Choudhury, Rajarshi Roy, Samantha A. Michaels, Kayode K. Ojo, Abhisheka Bansal   +5 more
doaj   +1 more source

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease

Neural Regeneration Research
Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon regulatory factor 7-mediated signaling contributes to Parkinson’s disease remains unknown.
Shengyang Zhou, Ting Li, Wei Zhang, Jian Wu, Hui Hong, Wei Quan, Xinyu Qiao, Chun Cui, Chenmeng Qiao, Weijiang Zhao, Yanqin Shen   +10 more
doaj   +1 more source

PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges

Frontiers in Oncology
Phosphodiesterase 10A (PDE10A) is a dual-substrate enzyme that hydrolyzes both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), playing a critical role in regulating intracellular signaling pathways. While its function has
Sahar Ghoflchi, Sahar Ghoflchi, Ali Nakhaei, Farzaneh Abbasinezhad-Moud, Mohammad Jalili-Nik, Patrick J. Cimino   +5 more
doaj   +1 more source

Analysis of substrate specificity and kinetics of cyclic nucleotide phosphodiesterases with N'-methylanthraniloyl-substituted purine and pyrimidine 3',5'-cyclic nucleotides by fluorescence spectrometry.

PLoS ONE, 2013
As second messengers, the cyclic purine nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) play an essential role in intracellular signaling.
Daniel Reinecke, Frank Schwede, Hans-Gottfried Genieser, Roland Seifert   +3 more
doaj   +1 more source

Uptake of ³H-cAMP by retinal pigment epithelium isolated from bluegill sunfish (Lepomis macrochirus)

BMC Neuroscience, 2006
Background In bluegill sunfish, the melanin-containing pigment granules of the retinal pigment epithelium undergo cyclic movements in response both to ambient lighting and circadian cues.
Moredock Steve, Radhakrishnan Varsha, Keith Thomas A, García Dana M   +3 more
doaj   +1 more source

Cyclic adenosine monophosphate, CA++, and membranes. [PDF]

Proceedings of the National Academy of Sciences, 1968
Since the initial discovery of cyclic 3',5'-adenosine monophosphate (3',5'AMP) by Rall, Sutherland, and Berthet' and its role in glycogenolysis in the liver,2 evidence has accumulated indicating that this nucleotide is an intermediate in the action of many peptide hormones.3-9 More recently it has also been implicated in the release of insulin from the
H, Rasmussen, A, Tenenhouse
openaire   +2 more sources

Chiral Resolution of a New Agent against Memory Impairment Connected to Neurodegenerative Diseases

Proceedings, 2019
Nowadays, the incidence of neurodegenerative diseases is increasing, and these disorders will become one of the main challenges for medicine and public health in future years.
Valeria Cavalloro, Marta Rui, Giacomo Rossino, Daniela Rossi, Federica Rapetti, Chiara Brullo, Olga Bruno, Simona Collina   +7 more
doaj   +1 more source

Control of Neurospora crassa morphology by cyclic adenosine 3', 5'-monophosphate and dibutyryl cyclic adenosine 3', 5'-monophosphate [PDF]

Journal of Bacteriology, 1976
The role of cyclic adenosine 3', 5'-monophosphate (cyclic AMP) in the control of the Neurospora asexual life cycle was studied. Endogenous cyclic AMP levels were 10 to 20 times higher in strains having the wild-type cr-1 allele than in those carrying the mutated allele.
H F, Terenzi, M M, Flawia, M T, Tellez-Inon, H N, Torres   +3 more
openaire   +2 more sources

AMPc: una molécula clave en los eventos de regulación inmune y en el control de la replicación del VIH cAMP: A keymolecule in events of immune regulation and in the control of HIV replication

Infectio, 2012
El monofosfato de adenosina cíclico (AMPc) induce la activación de la proteína cinasa A, la cual regula negativamente la activación, la proliferación celular y la producción de IL-2, en células T.
César Mauricio Rueda, Paula Andrea Velilla, Mauricio Rojas, María Teresa Rugeles   +3 more
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