Results 31 to 40 of about 588,356 (243)
Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes
Journal of Cardiovascular Development and Disease, 2018 Cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains.
Nikoleta Pavlaki, Viacheslav O. Nikolaev
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The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review
Frontiers in Pharmacology, 2022 Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the homeostasis of 3ʹ,5ʹ-cyclic adenosine monophosphate (cAMP) and 3ʹ,
Nazir Ahmad +5 more
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"cAMP sponge": a buffer for cyclic adenosine 3', 5'-monophosphate. [PDF]
PLoS ONE, 2009 BACKGROUND:While intracellular buffers are widely used to study calcium signaling, no such tool exists for the other major second messenger, cyclic AMP (cAMP). METHODS/PRINCIPAL FINDINGS:Here we describe a genetically encoded buffer for cAMP based on the
Konstantinos Lefkimmiatis +3 more
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Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 1999 The cyclic adenosine 3’, 5’-monophosphate (cAMP) production was evaluated in liver thin sections of broiler chicks fed on a experimental diet containing bicalcium phosphate or Araxá rock phosphate (ARP) as source of P, with a high content of fluorine, at
M.J.M. Rezende +2 more
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<em>Bacillus anthracis</em> Edema Factor Substrate Specificity: Evidence for New Modes of Action
Toxins, 2012 Since the isolation of <em>Bacillus anthracis</em> exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Roland Seifert +2 more
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Cyclic AMP Accumulation in Migraine Induction
Pediatric Neurology Briefs, 2015 Investigators from Danish Headache Centre, Glostrup Hospital, and the University of Copenhagen investigated whether intracellular cyclic AMP accumulation induced migraine attacks among 14 migraine patients without aura.
Ana B Chelse, Leon G Epstein
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Characterization of the taste receptor‐related G‐protein, α‐gustducin, in pancreatic β‐cells
Journal of Diabetes Investigation, 2020 Aims/Introduction Taste receptors, T1rs and T2rs, and the taste‐selective G‐protein, α‐gustducin, are expressed outside the taste‐sensing system, such as enteroendocrine L cells.
Haruhide Udagawa +7 more
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Molecular Mechanism of Light-Induced Acceleration of the Adenosine Triphosphate Conversion to the Cyclic Adenosine Monophosphate Catalyzed by the Photoactivated Adenylyl Cyclase bPAC [PDF]
, 2020 We report the first computational characterization of an optogenetic system composed of two photosensing BLUF (blue light sensor using flavin adenine dinucleotide) domains and two catalytic adenylyl cyclase (AC) domains.
Maria, Khrenova +2 more
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Cyclic AMP Receptor Protein from Yeast Mitochondria [PDF]
, 1985 We have identified and characterized a cyclic AMP receptor protein in mitochondria of the yeast Saccharomyces cerevisiae. The binding is specific for cyclic nucleotides, particularly for cyclic AMP which is bound with high affinity (Kd of 10(-9) M) at 1 ...
Rödel, Gerhard +2 more
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European Journal of Histochemistry, 2012 In Dictyostelium discoideum (D. discoideum), compounds generating nitric oxide (NO) inhibit its aggregation and differentiation without altering cyclic guanosine monophosphate (cGMP) production.
A. Amaroli, M.G. Chessa
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