Results 21 to 30 of about 117,365 (258)
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Identifizierung und Charakterisierung eines neuen Bindeproteins für zyklische Nukleotide [PDF]
, 2007 Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate are important intracellular messengers. Binding of cyclic nucleotides controls the activity of protein kinases, ion channels and guanine-nucleotide-exchange factors in many cells ...
Debowski, Katharina
core
Cyclic adenosine monophosphate, CA++, and membranes. [PDF]
Proceedings of the National Academy of Sciences, 1968 Since the initial discovery of cyclic 3',5'-adenosine monophosphate (3',5'AMP) by Rall, Sutherland, and Berthet' and its role in glycogenolysis in the liver,2 evidence has accumulated indicating that this nucleotide is an intermediate in the action of many peptide hormones.3-9 More recently it has also been implicated in the release of insulin from the
H, Rasmussen, A, Tenenhouse
openaire +2 more sources
Advanced Science, EarlyView.A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou +10 more
wiley +1 more source
Induction of dark-adaptive retinomotor movement (cell elongation) in teleost retinal cones by cyclic adenosine 3,5-monophosphate. [PDF]
, 1982 In the teleost retina, the photoreceptors and retinal pigment epithelium (RPE) undergo extensive movements (called retinomotor movements) in response to changes in light conditions and to an endogenous circadian rhythm.
BURNSIDE, Beth +3 more
core
Control of Neurospora crassa morphology by cyclic adenosine 3', 5'-monophosphate and dibutyryl cyclic adenosine 3', 5'-monophosphate [PDF]
Journal of Bacteriology, 1976 The role of cyclic adenosine 3', 5'-monophosphate (cyclic AMP) in the control of the Neurospora asexual life cycle was studied. Endogenous cyclic AMP levels were 10 to 20 times higher in strains having the wild-type cr-1 allele than in those carrying the mutated allele.
H F, Terenzi +3 more
openaire +2 more sources
Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
The effects of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons [PDF]
, 1980 Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt.
Benichou, J +3 more
core
Cyclic nucleotide signalling in malaria parasites. [PDF]
, 2017 The cyclic nucleotides 3', 5'-cyclic adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types.
Baker, David A +6 more
core +1 more source