Results 41 to 50 of about 588,356 (243)

Effects of cyclic nucleotides on midgut infections and maturation of T. b. brucei in G. m. morsitans

Parasites & Vectors, 2008
Cyclic nucleotide signalling through cyclic adenosine monophosphate (cAMP) is thought to play an important role in the transformation of the long slender (dividing) form to the short-stumpy (arrested) form in the mammalian bloodstream but the role of ...
Maudlin Ian, MacLeod Ewan T, Welburn Susan C   +2 more
doaj   +1 more source

Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway

Journal of Pharmacological Sciences, 2020
Recently, we has reported that AMPK activator has antidepressant effect. Previous our study suggested that liver hydrolysate (LH) activated adenosine monophosphate-activated protein kinase (AMPK) in periphery.
Osamu Nakagawasai, Kotaro Yamada, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Wakana Sakuma, Miharu Wakou, Jia-Rong Lin, Koichi Tan-No   +8 more
doaj   +1 more source

From Cells to Microphysiological Systems: 3D Cell Cultures and Organ-on-Chip Systems for Studying cAMP and cGMP Signaling

Organoids
Cyclic adenosine monophosphate and cyclic guanosine monophosphate are key regulators of cellular physiology and tissue homeostasis. Conventional experimental models have provided fundamental insights into cyclic nucleotide pathways; however, they often ...
Maria Rita Assenza, Nicole Bertani, Martina Pinna, Federica Campolo   +3 more
doaj   +1 more source

Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2019
Judy King, Sarah Sayner, Natalie Bauer   +2 more
exaly   +2 more sources

Vinpocetine is the forthcoming adjuvant agent in the management of COVID-19

Future Science OA, 2022
Vinpocetine (VPN) is an alkaloid derivative of vincamine inhibits phosphodiesterase type 1 that increase cyclic guanosine monophosphate and cyclic adenosine monophosphate. VPN have anti-inflammatory and antioxidant effects with suppression release of pro-
Hayder M Al-kuraishy, Ali I Al-Gareeb, Muyiwa Samuel Fageyinbo, Gaber El-Saber Batiha   +3 more
doaj   +1 more source

Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production

Frontiers in Microbiology, 2021
Type I interferons (IFN), a family of cytokines widely expressed in various tissues, play important roles in anti-infection immunity. Nevertheless, it is not known whether Brucella spp.
Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong   +9 more
doaj   +1 more source

Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012

Molecules, 2016
Cyclic nucleotide phosphodiesterases (PDEs) are a class of intracellular enzymes that inactivate the secondary messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP).
Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Matthias Scheunemann, Peter Brust   +4 more
doaj   +1 more source

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Günter Müller, Bandlow, Wolfhard, Wolfhard Bandlow, Müller, Günter   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway

Molecules, 2011
Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear.
Xuming Deng, Xuelin Wang, Guoren Huang, Wenhui Qian, Shuang Guan, Wei Wang, Jing Lu   +6 more
doaj   +1 more source