Results 1 to 10 of about 32,671 (149)
Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase [PDF]
Journal of Biological Chemistry, 2006 Beta-catenin is a signaling molecule that promotes cell proliferation by the induction of gene transcription through the activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription factors. The canonical mechanism of the regulation of beta-catenin involves its phosphorylation by casein kinase 1 at the Ser-45 site and by glycogen ...
Sébastien Taurin +4 more
openalex +4 more sources
Kv4.2 Phosphorylation by Cyclic AMP-dependent Protein Kinase [PDF]
Journal of Biological Chemistry, 2000 Recent evidence suggests that K(+) channels composed of Kv4.2 alpha-subunits underlie a transient current in hippocampal CA1 neurons and ventricular myocytes, and activation of the cAMP second messenger cascade has been shown to modulate this transient current. We determined if Kv4.2 alpha-subunits were directly phosphorylated by cAMP-dependent protein
A E, Anderson +5 more
openaire +2 more sources
Cyclic AMP‐dependent protein kinase does not phosphorylate cyclic GMP‐dependent protein kinase in vitro [PDF]
FEBS Letters, 1983 The autophosphorylation reaction of purified cGMP‐dependent protein kinase has been studied. Apparent initial rates of autophosphorylation in the absence of cyclic nucleotides and in the presence of cGMP and cAMP are 0.006, 0.04, 0.4 mol. Pi incorp./min−1.mol cGMP‐kinase subunit−1.
Hofmann, F., Gensheimer, H.-P.
openaire +2 more sources
Yeast cyclic AMP‐dependent protein kinase [PDF]
FEBS Letters, 1983 We have purified cyclic AMP‐dependent protein kinase from the yeast Saccharomyces cerevisiae. The purified enzyme was inactive in the absence of cyclic AMP and displayed two protein bands on SDS gel electrophoresis. One was identified as the cAMP‐binding protein by chromatography on cAMP‐agarose. M r of the latter was 50 000 while the catalytic subunit
openaire +2 more sources
Association of cyclic-AMP-dependent protein kinase with neurofilaments [PDF]
Biochemical Journal, 1992 Neurofilament preparations isolated from bovine spinal cord contain cyclic-AMP-dependent protein kinase (PKA) activity. Treatment of this preparation with cyclic AMP, to dissociate the regulatory subunit of the kinase from the catalytic subunit, resulted in retention of the kinase activity but loss of cyclic AMP regulation.
A, Dosemeci, H C, Pant
openaire +2 more sources
Ezrin is a cyclic AMP-dependent protein kinase anchoring protein [PDF]
The EMBO Journal, 1997 cAMP-dependent protein kinase (A-kinase) anchoring proteins (AKAPs) are responsible for the subcellular sequestration of the type II A-kinase. Previously, we identified a 78 kDa AKAP which was enriched in gastric parietal cells. We have now purified the 78 kDa AKAP to homogeneity from gastric fundic mucosal supernates using type II A-kinase regulatory ...
D T, Dransfield +6 more
openaire +2 more sources
Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase
Molecular and Cellular Biology, 1999 Activation of protein kinase B (PKB) by growth factors and hormones has been demonstrated to proceed via phosphatidylinositol 3-kinase (PI3-kinase). In this report, we show that PKB can also be activated by PKA (cyclic AMP [cAMP]-dependent protein kinase) through a PI3-kinase-independent pathway. Although this activation required phosphorylation of PKB,
N, Filippa +4 more
openaire +3 more sources
Engineering a bioluminescent indicator for cyclic AMP-dependent protein kinase [PDF]
Biochemical Journal, 1991 cDNA coding for the luciferase in the firefly Photinus pyralis was amplified in vitro to generate cyclic AMP-dependent protein kinase phosphorylation sites. The DNA was transcribed and translated to generate light-emitting protein. A valine at position 217 was mutated to arginine to generate a site RRFS and the heptapeptide kemptide, the ...
G B, Sala-Newby, A K, Campbell
openaire +2 more sources
Cyclic AMP binding proteins and cyclic AMP-dependent protein kinase from Blastocladiella emersonii [PDF]
Journal of Bacteriology, 1978 The stoichiometry of cyclic AMP binding protein to cyclic AMP in sporulating cells of Blastocladiella emersonii and the resistance of protein-bound cyclic AMP to enzyme-catalyzed hydrolysis suggest that the distribution of cyclic AMP between free and protein-bound pools is an important factor in cyclic AMP metabolism. Most but not all of the cyclic AMP
openaire +2 more sources
Regulation of cholesterol ester hydrolase by cyclic AMP‐dependent protein kinase [PDF]
FEBS Letters, 1986 Cholesterol ester hydrolase Phosphorylation Steroidogenesis
Colbran, Roger J. +3 more
openaire +2 more sources