Casomorphine-10 (CM-10) Peptide Orchestrates Circadian and Neurodevelopmental Gene Clusters via δ-Opioid Receptor Signaling: Insights from Transcriptome Analysis with δ-Opioid Receptor-Expressing HEK293 Cells [PDF]
LifeBackground: β-casomorphin-10 (CM-10), a peptide fragment derived from milk casein with the sequence YPFPGPIPNS, has demonstrated notable anxiolytic activity in BALB/c mice.
Moe Fukunaga +3 more
doaj +2 more sources
Engineering a bioluminescent indicator for cyclic AMP-dependent protein kinase [PDF]
Biochemical Journal, 1991 cDNA coding for the luciferase in the firefly Photinus pyralis was amplified in vitro to generate cyclic AMP-dependent protein kinase phosphorylation sites. The DNA was transcribed and translated to generate light-emitting protein. A valine at position 217 was mutated to arginine to generate a site RRFS and the heptapeptide kemptide, the ...
Graciela B. Sala‐Newby +1 more
openalex +4 more sources
Experimental Hematology & Oncology, 2022 Background The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells.
Jae Heun Chung +14 more
doaj +1 more source
Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)
Biology, 2023 Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.
Colin L. Welsh +2 more
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Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults and explored mechanisms ...
Yi Zong +10 more
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Association of cyclic-AMP-dependent protein kinase with neurofilaments [PDF]
Biochemical Journal, 1992 Neurofilament preparations isolated from bovine spinal cord contain cyclic-AMP-dependent protein kinase (PKA) activity. Treatment of this preparation with cyclic AMP, to dissociate the regulatory subunit of the kinase from the catalytic subunit, resulted in retention of the kinase activity but loss of cyclic AMP regulation.
A, Dosemeci, H C, Pant
openaire +2 more sources
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. [PDF]
PLoS ONE, 2010 Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in ...
Naval P Shanware +5 more
doaj +1 more source
PM<sub>2.5</sub> affected ciliary beat frequency of axonemes via the cyclic AMP-dependent protein kinase a pathway. [PDF]
Front Public HealthPang J, Xiong Z, Zhang K, Li Y.
europepmc +3 more sources
Kv4.2 Phosphorylation by Cyclic AMP-dependent Protein Kinase [PDF]
Journal of Biological Chemistry, 2000 Recent evidence suggests that K(+) channels composed of Kv4.2 alpha-subunits underlie a transient current in hippocampal CA1 neurons and ventricular myocytes, and activation of the cAMP second messenger cascade has been shown to modulate this transient current. We determined if Kv4.2 alpha-subunits were directly phosphorylated by cAMP-dependent protein
A E, Anderson +5 more
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Deciphering the structural basis of eukaryotic protein kinase regulation. [PDF]
PLoS Biology, 2013 Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain.
Hiruy S Meharena +7 more
doaj +1 more source