Experimental Hematology & Oncology, 2022 Background The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells.
Jae Heun Chung +14 more
doaj +1 more source
Inferring Compensatory Kinase Networks in Yeast using Prolog [PDF]
EPTCS 385, 2023, pp. 260-273, 2023 Signalling pathways are conserved across different species, therefore making yeast a model organism to study these via disruption of kinase activity. Yeast has 159 genes that encode protein kinases and phosphatases, and 136 of these have counterparts in humans.
arxiv +1 more source
Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)
Biology, 2023 Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.
Colin L. Welsh +2 more
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High efficient cyclic electron flow and functional supercomplexes in Chlamydomonas cells [PDF]
Biochimica biophysica acta (BBA) - Bioenergetics, 2022, 1863 (8),
pp.148909, 2023 A very high rate for cyclic electron flow (CEF) around PSI (~180 s-1 or 210 s-1 in minimum medium or in the presence of a carbon source respectively) is measured in the presence of methyl viologen (MV) in intact cells of Chlamydomonas reinhardtii under anaerobic conditions.
arxiv +1 more source
Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults and explored mechanisms ...
Yi Zong +10 more
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Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. [PDF]
PLoS ONE, 2010 Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in ...
Naval P Shanware +5 more
doaj +1 more source
Deciphering the structural basis of eukaryotic protein kinase regulation. [PDF]
PLoS Biology, 2013 Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain.
Hiruy S Meharena +7 more
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Cyclic Nucleotide-Directed Protein Kinases in Cardiovascular Inflammation and Growth
Journal of Cardiovascular Development and Disease, 2018 Cardiovascular disease (CVD), including myocardial infarction (MI) and peripheral or coronary artery disease (PAD, CAD), remains the number one killer of individuals in the United States and worldwide, accounting for nearly 18 million (>30%) global ...
Nathan A. Holland +6 more
doaj +1 more source
Immunofluorescent localization of cyclic nucleotide-dependent protein kinases on the mitotic apparatus of cultured cells [PDF]
, 1980 Cyclic nucleotides and cyclic nucleotide-dependent protein kinases have been implicated in the regulation of cell motility and division, processes that depend on the cell cytoskeleton.
Beavo, Joseph A. +4 more
core +2 more sources
Downstream Targets of Cyclic Nucleotides in Plants
Frontiers in Plant Science, 2018 Efficient integration of various external and internal signals is required to maintain adaptive cellular function. Numerous distinct signal transduction systems have evolved to allow cells to receive these inputs, to translate their codes and ...
Brygida Świeżawska +3 more
doaj +1 more source