Results 1 to 10 of about 88,247 (276)

Phosphorylation-mediated Activation and Translocation of the Cyclic AMP-specific Phosphodiesterase PDE4D3 by Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinases [PDF]

Journal of Biological Chemistry, 1999
In this study, we describe a novel mechanism by which a protein kinase C (PKC)-mediated activation of the Raf-extracellular signal-regulated kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) cascade regulates the activity and membrane ...
Hanguan Liu, D. Maurice
semanticscholar   +2 more sources

Casomorphine-10 (CM-10) Peptide Orchestrates Circadian and Neurodevelopmental Gene Clusters via δ-Opioid Receptor Signaling: Insights from Transcriptome Analysis with δ-Opioid Receptor-Expressing HEK293 Cells [PDF]

Life
Background: β-casomorphin-10 (CM-10), a peptide fragment derived from milk casein with the sequence YPFPGPIPNS, has demonstrated notable anxiolytic activity in BALB/c mice.
Moe Fukunaga, Shin Watanabe, Kanami Orihara, Naoyuki Yamamoto   +3 more
doaj   +2 more sources

Engineering a bioluminescent indicator for cyclic AMP-dependent protein kinase [PDF]

Biochemical Journal, 1991
cDNA coding for the luciferase in the firefly Photinus pyralis was amplified in vitro to generate cyclic AMP-dependent protein kinase phosphorylation sites. The DNA was transcribed and translated to generate light-emitting protein. A valine at position 217 was mutated to arginine to generate a site RRFS and the heptapeptide kemptide, the ...
G B, Sala-Newby, A K, Campbell
openaire   +4 more sources

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]

, 2015
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi, A Cheong, A Cogolludo, A Moreno-Dominguez, AJ Wilson, AM Brainard, B Kyle, B Razani, B Razani, C Dart, C Dart, Carl P. Nelson, CL Moore, CP Nelson, CP Nelson, DP McEwen, DW Carr, EA Aiello, EA Aiello, EA Ko, EA Ko, F Plane, GC Wellman, GI Purves, H Li, H Miyoshi, HS Mason, IA Greenwood, J Couet, J Moral-Sanz, JB Stott, JD Scott, JD Turner, Jennifer L. Brignell, JM Quayle, Jonathon M. Willets, JR Martens, KD Luykenaar, KS Park, LF Santana, LJ Sampson, LM Davies, M Colledge, Mark S. Shapiro, Matthew D. Perry, MF Navedo, MG Gold, MT Nelson, NM Alto, NN Orie, Noel W. Davies, O Clement-Chomienne, P Skroblin, R. A. John Challiss, RD Rainbow, RD Rainbow, RD Rainbow, RH Cox, RT Dobrowsky, SA Barman, VM Coghlan, Y Hayabuchi, Y Hayabuchi, Y Hayabuchi, Y Yang   +64 more
core   +4 more sources

Endogenous substrate proteins for Ca2+-calmodulin-dependent, Ca2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets. [PDF]

Biochemical Journal, 1984
P. Thams, K. Capito, C. J. Hedeskov
semanticscholar   +2 more sources

MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer

Experimental Hematology & Oncology, 2022
Background The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells.
Jae Heun Chung, Ho Jung Choi, Yong Jung Kang, Yun Seong Kim, Sang-Yull Lee, Ryuk Jun Kwon, Han-Sol Jeong, Su-Jung Park, Yeongmu Jeong, Dongwan Kang, Jeongin Ko, SangGyun Noh, Hae Young Chung, Hyung Ryong Moon, Seong Hoon Yoon   +14 more
doaj   +1 more source

Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)

Biology, 2023
Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation.
Colin L. Welsh, Abigail E. Conklin, Lalima K. Madan   +2 more
doaj   +1 more source

Kv4.2 Phosphorylation by Cyclic AMP-dependent Protein Kinase [PDF]

Journal of Biological Chemistry, 2000
Recent evidence suggests that K(+) channels composed of Kv4.2 alpha-subunits underlie a transient current in hippocampal CA1 neurons and ventricular myocytes, and activation of the cAMP second messenger cascade has been shown to modulate this transient current. We determined if Kv4.2 alpha-subunits were directly phosphorylated by cAMP-dependent protein
A E, Anderson, J P, Adams, Y, Qian, R G, Cook, P J, Pfaffinger, J D, Sweatt   +5 more
openaire   +2 more sources

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults and explored mechanisms ...
Yi Zong, Lin Sun, Bin Liu, Yi-Shu Deng, Dong Zhan, Yuan-Li Chen, Ying He, Jing Liu, Zong-Ji Zhang, Jun Sun, Di Lu   +10 more
doaj   +1 more source

Cyclic AMP-dependent Protein Kinase in Paramecium tetraurelia

Journal of Biological Chemistry, 1989
M Hochstrasser, D L Nelson
openaire   +2 more sources