Results 141 to 150 of about 1,140,604 (331)

Barnes Hospital Bulletin [PDF]

, 1971
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1071/thumbnail ...

core   +1 more source

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Science, 2013
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J. Chen   +4 more
semanticscholar   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Membrane-embedded CdaA is required for efficient synthesis of second messenger cyclic di-AMP

Communications Biology
Cyclic di-adenylate monophosphate (cyclic di-AMP) is an important second messenger in microorganisms. Cyclic di-AMP regulates bacterial cell volume and turgor via control of potassium and compatible solute transport but is also involved in many other ...
Alexander J. Foster, Haoyang Li, Panagiotis Drougkas, Gea. K. Schuurman-Wolters, Joeri ten Kate, Cristina Paulino, Bert Poolman   +6 more
doaj   +1 more source

Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP. [PDF]

Nucleic Acids Res, 2023
Lyu Z, Villanueva P, O'Malley L, Murphy P, Augenstreich J, Briken V, Singh A, Ling J.   +7 more
europepmc   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder

Pharmaceuticals
Autism spectrum disorder (ASD) and Fragile X syndrome (FXS) are neurodevelopmental disorders marked by deficits in communication and social interaction, often accompanied by anxiety, seizures, and intellectual disability.
Shilu Deepa Thomas, Hend Abdulaziz Mohammed, Mohammad I. K. Hamad, Murat Oz, Yauhen Statsenko, Bassem Sadek   +5 more
doaj   +1 more source

Science‐Towards‐Technology Breakthrough in CO2 Electroreduction: Multiphysics, Multiscale, and Artificial Intelligence Insights

Advanced Materials, EarlyView.
Electrochemical CO2RR is a key technology for converting CO2 into chemicals, but there remains a gap between “laboratory science” and “engineering practice” in current research. This review establishes a multi‐scale research framework, encompassing atomic‐level characterization, microenvironment regulation, external field‐assisted optimization, and AI ...
Ping Hong, Changfan Xu, Huaping Zhao, Yong Lei   +3 more
wiley   +1 more source

Clinical pharmacology of cardiac cyclic AMP in human heart failure: too much or too little? [PDF]

Expert Rev Clin Pharmacol, 2023
Lymperopoulos A.
europepmc   +1 more source

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

Advanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu, Mengyao Zhang, Zitong Qiu, Xinyi Liu, Yunsheng Dou, Sona Krizkova, Zheyi Li, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source