The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder
PharmaceuticalsAutism spectrum disorder (ASD) and Fragile X syndrome (FXS) are neurodevelopmental disorders marked by deficits in communication and social interaction, often accompanied by anxiety, seizures, and intellectual disability.
Shilu Deepa Thomas +5 more
doaj +1 more source
Clinical pharmacology of cardiac cyclic AMP in human heart failure: too much or too little? [PDF]
Expert Rev Clin Pharmacol, 2023 Lymperopoulos A.
europepmc +1 more source
SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]
, 2019 The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon ...
Corn, Jacob E +10 more
core
Cyclic AMP Regulates Aquaporin 5 Expression at Both Transcriptional and Post-transcriptional Levels through a Protein Kinase A Pathway [PDF]
, 2003 Fan Yang +2 more
openalex +1 more source
Real‐Time 3D Ultrasound Imaging with an Ultra‐Sparse, Low Power Architecture
Advanced Healthcare Materials, EarlyView.This article presents a novel, ultra‐sparse ultrasound architecture that paves the way for wearable real‐time 3D imaging. By integrating a unique convolutional array with chirped data acquisition, the system achieves high‐resolution volumetric scans at a fraction of the power and hardware complexity.
Colin Marcus +9 more
wiley +1 more source
Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility. [PDF]
, 1987 Ronald E. Weishaar +3 more
openalex +1 more source
Shapeshifting Liquid Metal Droplets for Soft Fluidic Machines
Advanced Materials, EarlyView.This study presented a liquid metal shape shifting strategy which harnesses Lorentz force, surface tension and fluid instabilities to achieve autonomous fluidic power. By using a liquid metal droplet as a mobile current carrier, this strategy enables the development of low‐voltage, self‐oscillating pumps that outperform existing soft pumps.
Saba Firouznia +5 more
wiley +1 more source
Cyclic AMP mediates ovine cumulus-oocyte gap junctional function via balancing connexin 43 expression and phosphorylation. [PDF]
Endocr Connect, 2023 Zhao Y +8 more
europepmc +1 more source
ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines. [PDF]
, 1989 The single-channel recording technique was employed to investigate the mechanism conferring ATP sensitivity to a metabolite-sensitive K channel in insulin-secreting cells.
Ciani, S, Eddlestone, GT, Ribalet, B
core