Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
Background: Cyclic dinucleotides (cyclic di-guanosine monophosphate (c-di-GMP) and cyclic di-adenosine monophosphate (c-di-AMP)) and lipopolysaccharides (LPS) are pathogen-associated molecular patterns (PAMPs).
Samira Elmanfi+5 more
doaj +1 more source
Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation [PDF]
The cyclic AMP-specific phosphodiesterase PDE8 has been shown to play a pivotal role in important processes such as steroidogenesis, T cell adhesion, regulation of heart beat and chemotaxis.
Baillie+30 more
core +1 more source
EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis [PDF]
BACKGROUND: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro.
Beier, Norbert+2 more
core +2 more sources
Pentacarbonyl(imidazolidine-2-thione-κS)tungsten(0)
In the title complex, [W(C3H6N2S)(CO)5], the W atom displays an octahedral coordination with five CO molecules and an imidazolidine-2-thione molecule. The W(CO)5 unit is coordinated by the cyclic thione ligand through a W—S dative bond.
Salah Merniz+4 more
doaj +1 more source
6-Bromo-2-methylsulfanyl-1,3-benzothiazole
The title molecule, C8H6BrNS2, is almost planar with a dihedral angle of 0.9 (1)° between the benzene and thiazole rings. The values of the geometry-based index of aromaticity (HOMA) and the nucleus-independent chemical shift (NICS ...
Michał A. Dobrowolski+2 more
doaj +1 more source
Role of cyclic AMP in the control of cell-specific gene expression [PDF]
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael+3 more
core +1 more source
Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes
Background: Cyclic AMP is a powerful inhibitor of platelet aggregation. In the present study we examined the effect of platelet aggregation modulators on cyclic AMP content in human thrombocytes.
Boyanov Krasimir O., Maneva Ana I.
doaj +1 more source
Induction of dark-adaptive retinomotor movement (cell elongation) in teleost retinal cones by cyclic adenosine 3,5-monophosphate. [PDF]
In the teleost retina, the photoreceptors and retinal pigment epithelium (RPE) undergo extensive movements (called retinomotor movements) in response to changes in light conditions and to an endogenous circadian rhythm.
BURNSIDE, Beth+3 more
core
Fate and regulation of anterior-like cells in Dictyostelium slugs [PDF]
A pattern of two tissue types exists in the Dictyostelium slug. Contained within the posterior tissue are anterior-like cells which comprise about 10% of the developing cell mass.
David, Charles N., Sternfeld, John
core +1 more source
Cyclic AMP but Not Calmodulin as a Potential Wasoconstrictor in Simulated Reperfusion. [PDF]
Ohla J+4 more
europepmc +1 more source