Results 11 to 20 of about 986,227 (410)

Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans [PDF]

Frontiers in Microbiology, 2018
Zinc is an essential micronutrient, required for a range of zinc-dependent enzymes and transcription factors. In mammalian cells, zinc serves as a second messenger molecule. However, a role for zinc in signaling has not yet been established in the fungal
Lasse Kjellerup, Lasse Kjellerup, Anne-Marie L. Winther, Duncan Wilson, Anja T. Fuglsang   +4 more
doaj   +5 more sources

Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis [PDF]

, 1978
Glucagon was tested for its effect on plasma adenosine 3′,5′-cyclic monophosphate (cyclic AMP), insulin, and glucose in healthy subjects and in patients with advanced cirrhosis of the liver. In the normal subjects, intravenous infusion of glucagon caused
Antonio Francavilla, Arthur F. Jones, Ball, Blonde, Bressler, Broadus, Broadus, Broadus, Brooker, Charles, Cherrington, Claycomb, Conn, Conn, Conn, Davies, Exton, Exton, Felig, Foa, Francavilla, Gilman, Hendy, Jerumo, Kaminsky, Kimmel, Krishna, Lambert, Lambert, Lambert, Levine, Liljenquist, Mackrell, Makman, Marco, McCullough, Milner, Miyamoto, Mori, Robison, Salomon, Sherwin, Srikant, Starzl, Strange, Strange, Sullivan, Sutherland, Taylor, Thomas E. Starzl, Turinsky, Turtle, Unger, Van Itallie, Vecchio, Verhaegen, Wahren, Walsh, White, Williams, Yalow, Zenser   +61 more
core   +1 more source

Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism? [PDF]

Diabetes & Metabolism Journal, 2020
Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription ...
Hye-Sook Han, Yongmin Kwon, Seung-Hoi Koo   +2 more
doaj   +1 more source

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

Journal of Neuroinflammation, 2016
BackgroundMicroglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment.
M. Ghosh, Yong Xu, D. Pearse
semanticscholar   +1 more source

Cyclic Amp And Psoriasis

Journal of Investigative Dermatology, 1975
Evidence that an adenyl cyclase system is present in all mammalian epidermis is reviewed. This adenyl cyclase is stimulated by at least two separate types of chemicals: catecholamines, which act at a beta-adrenergic receptor site, and prostaglandins of the E series, which act at a separate site.
K. Yoshikawa, Victor Levine, Kenji Adachi, Kenneth M. Halprin, S.L. Hsia, Mei Mei Mui   +5 more
openaire   +3 more sources

Copper Regulates Cyclic AMP-Dependent Lipolysis

Nature Chemical Biology, 2016
Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium, and zinc, but their redox-active transition metal counterparts such as copper and iron have been studied primarily as static enzyme ...
Lakshmi Krishnamoorthy, J. Cotruvo, J. Chan, H. Kaluarachchi, A. Muchenditsi, Venkata S. Pendyala, Shang Jia, Allegra T. Aron, Cheri M Ackerman, M. V. Wal, Timothy Guan, Lukas P Smaga, Samouil L. Farhi, Elizabeth J. New, S. Lutsenko, Christopher J. Chang   +15 more
semanticscholar   +1 more source

c-di-AMP: An essential molecule in the signaling pathways that regulate the viability and virulence of gram-positive bacteria [PDF]

, 2017
Signal transduction pathways enable organisms to monitor their external environment and adjust gene regulation to appropriately modify their cellular processes.
Cho, Kyu Hong, Fahmi, Tazin, Port, Gary C   +2 more
core   +2 more sources

Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

Molecular Metabolism, 2017
Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and
Shravan Babu Girada, Ramya S. Kuna, Shilpak Bele, Zhimeng Zhu, N.R. Chakravarthi, Richard D. DiMarchi, Prasenjit Mitra   +6 more
doaj   +1 more source

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Nature Communications, 2016
Biguanides such as metformin have previously been shown to antagonize hepatic glucagon-stimulated cyclic AMP (cAMP) signalling independently of AMP-activated protein kinase (AMPK) via direct inhibition of adenylate cyclase by AMP.
M. Johanns, Yu-Chiang Lai, Ming‐Fei Hsu, R. Jacobs, Didier Vertommen, J. Sande, J. E. Dumont, A. Woods, D. Carling, Louis Hue, Benoit Viollet, Benoit Viollet, Benoit Viollet, M. Foretz, M. Foretz, M. Foretz, M. Rider   +16 more
semanticscholar   +1 more source

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs [PDF]

, 2014
The cyclic AMP sensor, EPAC1, activates AP1-mediated transcription in HUVECs. Correspondingly, induction of the SOCS3 minimal promoter by EPAC1 requires a single AP1 site that constitutively binds phosphorylated (Ser63) c-Jun in DNA-pull-down assays.
Auernhammer, Bos, Cai, Curran, Davis, Eid, Hochbaum, Jolanta Wiejak, Julia Dunlop, Karin, MacLaren, Meinkoth, Netherton, Piessevaux, Ramberg, Rampersad, Sands, Schmidt, Stephen J. Yarwood, Wiejak, Wiejak, Woolson, Yarwood, Yarwood   +23 more
core   +1 more source