Results 11 to 20 of about 1,140,604 (331)

The Cyclic AMP Pathway [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
cAMP was the first second messenger to be identified. Its three main effectors are PKA (which phosphorylates numerous metabolic enzymes), EPAC (a guanine-nucleotide-exchange factor), and cyclic-nucleotide-gated ion channels.
P. Sassone-Corsi
openaire   +3 more sources

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

Journal of Biological Chemistry, 1990
A newly synthesized isoquinolinesulfonamide, H-89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline-sulfonamide), was shown to have a potent and selective inhibitory action against cyclic AMP-dependent protein kinase (protein kinase A), with an ...
T. Chijiwa, A. Mishima, M. Hagiwara, M. Sano, Kyozo Hayashi, Tsutomu Inoue, Naito Kenji, T. Toshioka, Hiroyoshi Hidaka   +8 more
semanticscholar   +1 more source

Relationship between the tissue level of cyclic AMP and the fat cell size of human adipose tissue.

Journal of Lipid Research, 1978
The relationship between mean fat cell size, maximal tissue cyclic AMP concentration, and glycerol release was investigated in human subcutaneous adipose tissue incubated in vitro with or without isoprenaline or noradrenaline added at maximal effective ...
P Arner, J Ostman
doaj   +1 more source

Non-Enzymatic Oligomerization of 3', 5' Cyclic AMP. [PDF]

PLoS ONE, 2016
Recent studies illustrate that short oligonucleotide sequences can be easily produced from nucleotide precursors in a template-free non-enzymatic way under dehydrating conditions, i.e. using essentially dry materials. Here we report that 3',5' cyclic AMP
Giovanna Costanzo, Samanta Pino, Anna Maria Timperio, Judit E Šponer, Jiří Šponer, Olga Nováková, Ondrej Šedo, Zbyněk Zdráhal, Ernesto Di Mauro   +8 more
doaj   +1 more source

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

Journal of Neuroinflammation, 2016
BackgroundMicroglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment.
M. Ghosh, Yong Xu, D. Pearse
semanticscholar   +1 more source

Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

Molecular Metabolism, 2017
Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and
Shravan Babu Girada, Ramya S. Kuna, Shilpak Bele, Zhimeng Zhu, N.R. Chakravarthi, Richard D. DiMarchi, Prasenjit Mitra   +6 more
doaj   +1 more source

Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis [PDF]

, 1978
Glucagon was tested for its effect on plasma adenosine 3′,5′-cyclic monophosphate (cyclic AMP), insulin, and glucose in healthy subjects and in patients with advanced cirrhosis of the liver. In the normal subjects, intravenous infusion of glucagon caused
Antonio Francavilla, Arthur F. Jones, Ball, Blonde, Bressler, Broadus, Broadus, Broadus, Brooker, Charles, Cherrington, Claycomb, Conn, Conn, Conn, Davies, Exton, Exton, Felig, Foa, Francavilla, Gilman, Hendy, Jerumo, Kaminsky, Kimmel, Krishna, Lambert, Lambert, Lambert, Levine, Liljenquist, Mackrell, Makman, Marco, McCullough, Milner, Miyamoto, Mori, Robison, Salomon, Sherwin, Srikant, Starzl, Strange, Strange, Sullivan, Sutherland, Taylor, Thomas E. Starzl, Turinsky, Turtle, Unger, Van Itallie, Vecchio, Verhaegen, Wahren, Walsh, White, Williams, Yalow, Zenser   +61 more
core   +1 more source

Copper Regulates Cyclic AMP-Dependent Lipolysis

Nature Chemical Biology, 2016
Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium, and zinc, but their redox-active transition metal counterparts such as copper and iron have been studied primarily as static enzyme ...
Lakshmi Krishnamoorthy, J. Cotruvo, J. Chan, H. Kaluarachchi, A. Muchenditsi, Venkata S. Pendyala, Shang Jia, Allegra T. Aron, Cheri M Ackerman, M. V. Wal, Timothy Guan, Lukas P Smaga, Samouil L. Farhi, Elizabeth J. New, S. Lutsenko, Christopher J. Chang   +15 more
semanticscholar   +1 more source

Cyclic AMP metabolism in adipose tissue of exercise-trained rats.

Journal of Lipid Research, 1978
Cyclic AMP metabolism in epididymal adipose tissue of exercise-trained rats was examined to determine if training induced changes in cyclic AMP production or inactivation.
E W Askew, A L Hecker, V G Coppes, F B Stifel   +3 more
doaj   +1 more source

The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets

Cells, 2020
The cell cycle is controlled by microtubule-associated serine/threonine kinase-like (MASTL), which phosphorylates the cAMP-regulated phosphoproteins 19 (ARPP19) at S62 and 19e/α-endosulfine (ENSA) at S67and converts them into protein phosphatase 2A (
Elena J. Kumm, Oliver Pagel, Stepan Gambaryan, Ulrich Walter, René P. Zahedi, Albert Smolenski, Kerstin Jurk   +6 more
doaj   +1 more source