Results 11 to 20 of about 1,008,469 (242)

PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner. [PDF]

Elife, 2023
Liu H, Wada A, Le I, Le PT, Lee AWF, Zhou J, Gori F, Baron R, Rosen CJ.   +8 more
europepmc   +2 more sources

Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated the expression of AM and its receptor components, including calcitonin receptor-like receptor (CLR) and receptor activity modifying proteins (RAMPs ...
Mohsen Sisakht, Zahra Khoshdel, Amir Mahmoodzadeh, Sayed Mohammad Shafiee, Mohammad Ali Takhshid   +4 more
doaj   +1 more source

Relationship between the tissue level of cyclic AMP and the fat cell size of human adipose tissue.

Journal of Lipid Research, 1978
The relationship between mean fat cell size, maximal tissue cyclic AMP concentration, and glycerol release was investigated in human subcutaneous adipose tissue incubated in vitro with or without isoprenaline or noradrenaline added at maximal effective ...
P Arner, J Ostman
doaj   +1 more source

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

Journal of Neuroinflammation, 2016
BackgroundMicroglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment.
M. Ghosh, Yong Xu, D. Pearse
semanticscholar   +1 more source

Copper Regulates Cyclic AMP-Dependent Lipolysis

Nature Chemical Biology, 2016
Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium, and zinc, but their redox-active transition metal counterparts such as copper and iron have been studied primarily as static enzyme ...
Lakshmi Krishnamoorthy, J. Cotruvo, J. Chan, H. Kaluarachchi, A. Muchenditsi, Venkata S. Pendyala, Shang Jia, Allegra T. Aron, Cheri M Ackerman, M. V. Wal, Timothy Guan, Lukas P Smaga, Samouil L. Farhi, Elizabeth J. New, S. Lutsenko, Christopher J. Chang   +15 more
semanticscholar   +1 more source

Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

Molecular Metabolism, 2017
Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and
Shravan Babu Girada, Ramya S. Kuna, Shilpak Bele, Zhimeng Zhu, N.R. Chakravarthi, Richard D. DiMarchi, Prasenjit Mitra   +6 more
doaj   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian, Ong, Wee Kiat, Pyne, Nigel J.   +2 more
core   +1 more source

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Nature Communications, 2016
Biguanides such as metformin have previously been shown to antagonize hepatic glucagon-stimulated cyclic AMP (cAMP) signalling independently of AMP-activated protein kinase (AMPK) via direct inhibition of adenylate cyclase by AMP.
M. Johanns, Yu-Chiang Lai, Ming‐Fei Hsu, R. Jacobs, Didier Vertommen, J. Sande, J. E. Dumont, A. Woods, D. Carling, Louis Hue, Benoit Viollet, Benoit Viollet, Benoit Viollet, M. Foretz, M. Foretz, M. Foretz, M. Rider   +16 more
semanticscholar   +1 more source

Cyclic AMP metabolism in adipose tissue of exercise-trained rats.

Journal of Lipid Research, 1978
Cyclic AMP metabolism in epididymal adipose tissue of exercise-trained rats was examined to determine if training induced changes in cyclic AMP production or inactivation.
E W Askew, A L Hecker, V G Coppes, F B Stifel   +3 more
doaj   +1 more source

Digital image processing of optical density wave propagation in Dictyostelium discoideum and analysis of the effects of caffeine and ammonia [PDF]

, 1989
Waves of chemotactic movement during the early phase of aggregation in Dictyostelium discoideum were analyzed by digital image processing in a manner that immediately shows the following parameters: wave propagation velocity, period length, wave ...
Siegert, Florian, Weijer, Cornelis J.
core   +1 more source