Results 41 to 50 of about 3,359,188 (286)
Activation of STING Based on Its Structural Features
Frontiers in Immunology, 2022 The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers.
Behzad Hussain +8 more
doaj +1 more source
Activation of hormone-sensitive lipase in extracts of adipose tissue
Journal of Lipid Research, 1970 Rat adipose tissue was homogenized in 0.154 m KCI, and the supernatant fluid, obtained after centrifugation at 15,000 g, was extracted with benzene to remove triglycerides. Most of the lipase activity in the extracted fluid was precipitated with ammonium
SU-CHEN TSAI +2 more
doaj +1 more source
Ultrasonics SonochemistryThe United Nations’ Sustainable Development Goals (SDGs) are significant in guiding modern scientific research. In recent years, scholars have paid much attention to MOFs materials as green materials.
Zhiwei Liu +8 more
doaj +1 more source
The Role of Cyclic AMP Signaling in Cardiac Fibrosis
Cells, 2019 Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is associated with cardiomyocyte death and development of fibrosis. The fibrotic process is initially triggered by the differentiation of resident cardiac fibroblasts
Marion Delaunay +3 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2012 cAMP was the first second messenger to be identified. Its three main effectors are PKA (which phosphorylates numerous metabolic enzymes), EPAC (a guanine-nucleotide-exchange factor), and cyclic-nucleotide-gated ion channels.
openaire +2 more sources
Annals of Surgery, 1976 Cyclic AMP is believed to be the intracellular agent which mediates the action of many hormones on their target cell. The mechanisms by which the nucleotide controls glycogen metabolism in liver and skeletal muscle seem to be firmly established. Data relevant to this area of research are selectively reviewed.
openaire +3 more sources
Microbiological Reviews, 1992 Cyclic AMP (cAMP) is found in a variety of prokaryotes including both eubacteria and archaebacteria. cAMP plays a role in regulating gene expression, not only for the classic inducible catabolic operons, but also for other categories. In the enteric coliforms, the effects of cAMP on gene expression are mediated through its interaction with and ...
J L, Botsford, J G, Harman
openaire +2 more sources
Fate and regulation of anterior-like cells in Dictyostelium slugs [PDF]
, 1982 A pattern of two tissue types exists in the Dictyostelium slug. Contained within the posterior tissue are anterior-like cells which comprise about 10% of the developing cell mass.
Sternfeld, John +3 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations [PDF]
, 2010 Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite ...
Terrin, A. +26 more
core +2 more sources