Results 51 to 60 of about 1,017,209 (339)
4-Carbamoylpiperidinium phenylacetate hemihydrate
Acta Crystallographica Section E, 2010 The asymmetric unit of the title compound, C6H13N2O+·C8H7O2−·0.5H2O, comprises two isonipecotamide cations, two phenylacetate anions and a water molecule of solvation.
Urs D. Wermuth, Graham Smith
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Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]
, 1979 Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM +3 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Acta Crystallographica Section E, 2010 The title compound, CH6N3+·C7H4NO4−, an anhydrous guanidinium salt, shows a N—H...O hydrogen-bond network in which the guanidinium cation is involved in three cyclic R21(6) hydrogen-bonding associations with separate ...
Graham Smith, Urs D. Wermuth
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Cyclic AMP Receptor Protein from Yeast Mitochondria [PDF]
, 1985 We have identified and characterized a cyclic AMP receptor protein in mitochondria of the yeast Saccharomyces cerevisiae. The binding is specific for cyclic nucleotides, particularly for cyclic AMP which is bound with high affinity (Kd of 10(-9) M) at 1 ...
Bandlow, Wolfhard +2 more
core
Role of cyclic AMP in the control of cell-specific gene expression [PDF]
, 1993 Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael +3 more
core +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
mSpherecAMP plays an important role as a second messenger in the stage transition of various protozoan parasites. This signaling pathway relies on multiple effectors, such as protein kinase A (PKA), exchange protein activated by cAMP, and cAMP-response element ...
Han-Wei Shih +2 more
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Journal of Lipid Research, 1973 The present study was undertaken to determine the relationship between the antilipolytic and lipolytic effects of insulin on hormone-stimulated lipolysis and the mechanisms of these reactions.
K.S. Desai, K.C. Li, A. Angel
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