Results 51 to 60 of about 233,579 (364)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Guanidinium phenylarsonate–guanidine–water (1/1/2)
Acta Crystallographica Section E, 2010 In the structure of the title compound, CH6N3+·C6H6AsO3−·CH5N3·2H2O, the phenylarsonate anion participates in two R22(8) cyclic hydrogen-bonding interactions, one with a guanidinium cation, the other with a guanidine ...
Graham Smith, Urs D. Wermuth
doaj +1 more source
Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]
, 1979 Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM +3 more
core
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
4-Carbamoylpiperidinium phenylacetate hemihydrate
Acta Crystallographica Section E, 2010 The asymmetric unit of the title compound, C6H13N2O+·C8H7O2−·0.5H2O, comprises two isonipecotamide cations, two phenylacetate anions and a water molecule of solvation.
Urs D. Wermuth, Graham Smith
doaj +1 more source
Attenuation of ischemic liver injury by prostaglandin E
, 1998 Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N +8 more
core +1 more source
Effects of Cyclic Amp and Dibutyryl Cyclic Amp on the Heart and Coronary Circulation
Japanese Journal of Pharmacology, 1974 Using the canine heart-lung preparation supported by a donor dog and the isolated right and left atrial preparations of the guinea-pig and the rat, the cardiac actions of dibutyryl cyclic AMP were studied and compared with those of cyclic. AMP. Dibutyryl cyclic AMP produced positive isotropic and chronotropic effects associated with an increase in the ...
Yumi Katano +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Advanced Biology, EarlyView.The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali +5 more
wiley +1 more source
Platelets, 2019 The pathophysiology of impaired platelet function in acquired disorders is often poorly understood. We report two unrelated patients with hematologic malignancies associated with acquired severe bleeding diathesis, and complex platelet function ...
Anna Lecchi +4 more
doaj +1 more source