Results 71 to 80 of about 3,359,188 (286)
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Guanidinium phenylarsonate–guanidine–water (1/1/2)
Acta Crystallographica Section E, 2010 In the structure of the title compound, CH6N3+·C6H6AsO3−·CH5N3·2H2O, the phenylarsonate anion participates in two R22(8) cyclic hydrogen-bonding interactions, one with a guanidinium cation, the other with a guanidine ...
Graham Smith, Urs D. Wermuth
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Cyclic AMP and cyclic GMP in rabbit blastocysts [PDF]
Reproduction, 1978 Summary. Concentrations of both nucleotides were significantly higher in Day-6 than in Day-5 blastocysts but the ratio of cAMP to cGMP changed from 0·5 to 1·5.
S K, Dey +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones
, 1986 'Wash-out' and inactivation of the Ca current were examined in dialysed, voltage-clamped neurones of Helix aspersa under conditions that isolate the Ca current virtually free of other currents. EGTA or other internal Ca2+ chelators were routinely omitted
Chad, J.E., Eckert, R.
core +1 more source
Cyclic AMP Receptor Protein−Aequorin Molecular Switch for Cyclic AMP [PDF]
Bioconjugate Chemistry, 2011 Molecular switches are designer molecules that combine the functionality of two individual proteins into one, capable of manifesting an "on/off" signal in response to a stimulus. These switches have unique properties and functionalities and thus, can be employed as nanosensors in a variety of applications.
Daniel, Scott +4 more
openaire +2 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
STUDIES ON DUODENAL CYCLIC AMP IN PANCREATIC DISEASE USING THE PANCREOZYMIN-SECRETIN TEST. [PDF]
, 1982 11例の健常例,18例の慢性膵炎例,6例の急性膵炎例および5例の膵癌例においてPS試験の際得られた十二指腸液中のcyclic AMPを測定した.cyclic AMPは健常群においてはsecretinによる膵bicarbonate分泌の細胞内mediatorとして働いていると考えられるが,膵疾患時にはcyclic AMP-bicarbonate分泌機構が円滑に働かないと考えられ,量的にもcyclic AMP outputは低下していた.すべての群においてcyclic AMP ...
Matsumoto, Rokuro, Rokuro MATSUMOTO
core +1 more source
1H-Pyrazol-2-ium hydrogen oxalate
Acta Crystallographica Section E, 2012 In the title compound, C3H5N2+·C2HO4−, the anions form centrosymmetric dimers through cyclic O—H...O hydrogen-bonding associations [graph set R22(10)].
Chun-Hua Yu, Run-Qiang Zhu
doaj +1 more source