Results 181 to 190 of about 58,029 (251)

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide. [PDF]

Med Gas Res
Farahani A, Farahani A, Kashfi K, Ghasemi A.   +3 more
europepmc   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

Genome-wide binding of the cyclic AMP receptor protein in EnteroaggregativeEscherichia colisuggests a role in modulating virulence

Alhammadi MM, Hothersall J, Lloyd GS, Titman SV, Guest T, Browning DF, Grainger DC, Busby SJ, Haycocks JR.   +8 more
europepmc   +1 more source

SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis. [PDF]

Cell Rep
Montefusco D, Jamil M, Canals D, Saligrama S, Yue Y, Allegood J, Cowart LA.   +6 more
europepmc   +1 more source

Metformin and Dietary Restriction Counteract Aging via Reducing m6A–Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

Aging Cell, EarlyView.
Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang, Xiaojie Liu, Hairong Lian, Yanchao Chai, Yang Zhou, Dongqi Kan, Jilong Ren, Cui Han, Jiaxin Yang   +8 more
wiley   +1 more source

Repurposing of Antiplatelet Agent: Cilostazol for the Treatment of Alcohol-Related Liver Disease. [PDF]

Gut Liver
Eun JR, Kim SU.
europepmc   +1 more source

Ethanol‐induced Nrf2 suppression in the lung is mediated by AP‐1‐driven expression of miR‐144

Alcohol, Clinical and Experimental Research, EarlyView.
Previously, we determined that ethanol suppresses Nrf2 and thereby inhibits antioxidant and immune defenses in the lung. Clinically, individuals with AUD are vulnerable to pneumonia and acute lung injury. In this new experimental study, we report that ethanol inhibits Nrf2 in rat lung cells via the induction of miR‐144 in a mechanism dependent on the ...
Viranuj Sueblinvong, Xian Fan, Justin Guo, Hui Tao, David M. Guidot   +4 more
wiley   +1 more source

Hunting down the elusive cytosolic-DNA sensor. [PDF]

Proc Natl Acad Sci U S A
Mathis D.
europepmc   +1 more source