Results 51 to 60 of about 20,142 (297)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Experimental study on deformation behaviors of saturated soft clay under intermittent cyclic loading with various drained conditions

Yantu gongcheng xuebao
In the previous studies, the cyclic triaxial tests under intermittent cyclic loading are used to study the deformation characteristics of soft clay under traffic loads. Both confining pressure and deviator stress vary cyclically in the stress field under
HUANG Juehao 1, 2, XU Linfeng 3, 1, LU Yuan 5, YAN Wenlong 4, 1, CHEN Jian 1, 2, FU Xiaodong 1, 2
doaj   +1 more source

Experimental Study on Mechanical Properties of Deep Buried Granite under Different Confining Pressures

Advances in Civil Engineering, 2020
Brittle failure of hard rock poses a serious threat to the stability of surrounding rock in deep underground engineering. In order to study the deformation and failure characteristics of deep buried granite under high confining pressure cyclic loading ...
Jun Zhao, Tan Zhang
doaj   +1 more source

Acoustically-induced slip in sheared granular layers: application to dynamic earthquake triggering [PDF]

, 2015
A fundamental mystery in earthquake physics is ``how can an earthquake be triggered by distant seismic sources?'' Here, we use discrete element method simulations of a granular layer, during stick-slip, that is subject to transient vibrational excitation
Carmeliet, Jan, Ferdowsi, Behrooz, Griffa, Michele, Guyer, Robert A., Johnson, Paul A., Marone, Chris   +5 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Road Performance and Water-Softening Characteristics of Stabilized Soil under Cyclic Loading

Zhongwai Gonglu
To effectively deal with waste soil and reduce environmental pollution, this paper took a road engineering project in Shaoxing as the research object and conducted a cyclic triaxial incremental loading test on the undisturbed lime soil under undrained ...
HU Hong, LI Zongheng, FENG Yong, CAO Zhigang, LIU Yaoxing   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Study on the mechanical properties of unloading damaged sandstone under cyclic loading and unloading

Scientific Reports, 2023
To reveal the mechanical properties of rocks under stress disturbance and unloading confining pressure, conventional triaxial compression tests, triaxial compression tests on unloading damaged sandstone, and cyclic loading and unloading tests on ...
Hengbin Zhang, Lehua Wang, Jianlin Li, Huafeng Deng, Xiaoliang Xu   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Post-Cyclic Mechanical Behaviors of Undisturbed Soft Clay with Different Degrees of Reconsolidation

Applied Sciences, 2021
Soft soil is often subjected to cyclic loading such as that imposed during storms, under traffic, or in an earthquake. Furthermore, the cyclic-loading-induced excess pore water pressure can be partially dissipated after cyclic loading.
Yuan Lu, Jian Chen, Juehao Huang, Libo Feng, Song Yu, Jianbin Li, Chao Ma   +6 more
doaj   +1 more source