Results 61 to 70 of about 20,015 (278)

Hydromechanical Coupling Characteristics of the Fractured Sandstone under Cyclic Loading-Unloading

Geofluids, 2020
The mechanical and hydraulic properties of rock mass play a crucial role in underground engineering. To study the effect of hydraulic pressure, confining pressure, and axial cyclic loading-unloading on variation of the deformation and permeability in ...
Tong Zhang, Yang Liu, Ke Yang, Ming Tang, Xiang Yu, Fei Yu   +5 more
doaj   +1 more source

Strain Limits for Concrete Filled Steel Tubes in AASHTO Seismic Provisions [PDF]

, 2013
INE/AUTC 13 ...
King Brown, Nicole, Kowalsky, Mervyn, Nau, James   +2 more
core  

Study on the Cyclic Impact Mechanical Characteristics of Coal under Confining Pressure

ACS Omega
Coal damage accumulation and strength deterioration caused by mining-induced disturbances in deep mines are among the factors influencing the occurrence of dynamic disasters such as rock bursts. To study the mechanical deformation and failure characteristics of coal masses under both cyclic impact and confining pressure, SHPB experiments were performed
He Yongliang, Sun Liying, Xing Xuegang
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Effect of confining pressure on the degradation of ballast under cyclic loading

Géotechnique, 2005
Traditional railway foundations or substructures have become increasingly overloaded in recent years due to the introduction of faster and heavier trains. A lack of substructure re-engineering has resulted in maintenance cycles becoming more frequent and increasingly expensive.
Indraratna, Buddhima, Lackenby, J., Christie, D.   +2 more
openaire   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Effects of grain size distribution on the initial strain shear modulus of calcareous sand [PDF]

, 2015
The soil’s small strain shear modulus, Gmax or G0, is applied in dynamic behavior analyses and is correlated to other soil properties (density and void ratio) for predicting soil dynamic behavior under seismic loadings such as earthquakes, machinery or ...
Haegeman, Wim, Mengé, P, Pham, Huu Ha Giang, Van Impe, PO, Van Impe, William   +4 more
core   +1 more source

Slope stability in slightly fissured claystones and marls [PDF]

, 2015
The final publication is available at Springer via http://dx.doi.org/10.1007/s10346-014-0526-5The paper deals with the behavior of some characteristic soft rocks found in the Iberian Peninsula.
Alonso Pérez de Agreda, Eduardo, Pinyol Puigmartí, Núria Mercè   +1 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source