Results 151 to 160 of about 3,689 (198)
Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications. [PDF]
Chem RevLombardi L +3 more
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Multifaceted Marine Peptides and Their Therapeutic Potential. [PDF]
Mar DrugsGuryanova SV, Ovchinnikova TV.
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Cyclic depsipeptides as potential cancer therapeutics
Anti-Cancer Drugs, 2015Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta, Kitagaki +4 more
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Trikoveramides A-C, cyclic depsipeptides from the marine cyanobacterium Symploca hydnoides
Phytochemistry, 2021Trikoveramides A - C, members of the kulolide superfamily of cyclic depsipeptides, were isolated from the marine cyanobacterium, Symploca hydnoides, collected from Bintan Island, Indonesia. Their planar structures were elucidated by a combination of NMR spectroscopy and HRMS spectral data.
Phyo, Ma Yadanar +3 more
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Macrocyclization strategies for the total synthesis of cyclic depsipeptides
Organic & Biomolecular Chemistry, 2023Cyclic depsipeptides, bioactive natural products containing ester(s) and amides in the macrocycle, are synthesizedvia3 strategies, macrolactamization in solution, macrolactamization on-resin, and macrolactonization.
André R. Paquette, Christopher N. Boddy
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The Cyclic Depsipeptide Backbone of the Didemnins
Acta Crystallographica Section C Crystal Structure Communications, 1995An X-ray crystal analysis of phi-lactone N-¿1-¿N-¿4-¿[3- hydroxy-5-methyl-1-oxo-4-(N-L-threonylamino)heptyl]- oxy¿-2,5-dimethyl-1,3-dioxohexyl¿-L-leucyl¿-L-prolyl¿- N,O-dimethyl-L-tyrosine hydrobromide hydrate (1a), C42H66N5O11+.Br-.H2O, was obtained in order to determine the backbone folding of the macrocycle and to compare the results obtained with ...
S C, Mayer, P J, Carroll, M M, Joullié
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Cyclic Depsipeptides, Callipeltins
2020Marine sponges are considered as an untapped reservoir of biologically active natural compounds exhibiting numerous interesting and potentially useful pharmacological activities, including antimicrobial, antifungal, cytotoxic, anti-inflammatory, and immunostimulatory activities.
Reda A. Abdelhamid, Hiroyuki Konno
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Total synthesis of antimicrobial and antitumor cyclic depsipeptides
Chemical Communications, 2010The total synthesis of natural products "has to be viewed as an art and a science that needs to be advanced for its own sake" (K. C. Nicolaou) and indeed, the achievements within this field of chemistry during the last decades are astonishing. However, besides its inherent beauty, total synthesis also opens the gates widely to a better understanding of
Wenhua, Li +2 more
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Total Synthesis of the Marine Cyclic Depsipeptide Viequeamide A
Journal of Natural Products, 2013The first total synthesis of viequeamide A, a natural cyclic depsipeptide isolated from a marine button cyanobacterium, was achieved with the N-Me-Val-Thr peptide bond as the final macrocyclization site. The synthetic product gave nearly identical spectroscopic data to that reported for the natural product.
Dongyu, Wang +5 more
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Cyclic Peptides and Depsipeptides from Fungi
2009This chapter describes the occurrence of cyclic peptides and cyclic depsipeptides within the kingdom Eumycota (true fungi), the diversity of structures and their chemical building blocks, their ecological roles and their different biological activities.
Heidrun Anke, Luis Antelo
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