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Total synthesis of antimicrobial and antitumor cyclic depsipeptides
Chemical Communications, 2010The total synthesis of natural products "has to be viewed as an art and a science that needs to be advanced for its own sake" (K. C. Nicolaou) and indeed, the achievements within this field of chemistry during the last decades are astonishing. However, besides its inherent beauty, total synthesis also opens the gates widely to a better understanding of
Wenhua, Li +2 more
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Cyclic Peptides and Depsipeptides from Fungi
2009This chapter describes the occurrence of cyclic peptides and cyclic depsipeptides within the kingdom Eumycota (true fungi), the diversity of structures and their chemical building blocks, their ecological roles and their different biological activities.
Heidrun Anke, Luis Antelo
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A Total Synthesis of the Cyclic Depsipeptide Chaiyaphumine‐A
ChemistrySelect, 2017Abstract The first total synthesis of Chaiyaphumine‐A, a cyclic depsipentapeptide isolated from Xenorhabdus SP. PB614 which showed good activity against Plasmodium falcifarum (IC 50 = 0.61 μM ...
Somnath S. Gholap, Sandip R. Ugale
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Chemistry and Biology of Cyclic Depsipeptides of Medicinal and Biological Interest
Current Medicinal Chemistry, 2004Cyclodepsipeptides comprise a wide variety of cyclic peptides of natural origin and are characterized by the occurrence of at least one ester linkage. The great interest that this class of natural products has elicited in scientific community is explained by their wide range of biological activities, intriguing mechanisms of action and attractive ...
Francisco, Sarabia +4 more
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Journal of the American Society for Mass Spectrometry
Depsipeptides, a structurally diverse class of nonribosomal peptides with broad bioactivities, present significant challenges for systematic characterization due to their complex fragmentation patterns in mass spectrometry (MS).
Huijie Sun +10 more
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Depsipeptides, a structurally diverse class of nonribosomal peptides with broad bioactivities, present significant challenges for systematic characterization due to their complex fragmentation patterns in mass spectrometry (MS).
Huijie Sun +10 more
semanticscholar +1 more source
Interaction of cyclic peptides and depsipeptides with calmodulin.
Peptide research, 1992A variety of small peptides bind calmodulin (CaM) and inhibit CaM-dependent enzyme activity. The cyclic peptides cyclosporin A (CSA) and gramicidin-S (GRS) are shown to bind CaM and inhibit 3',5'-cyclic nucleotide phosphodiesterase (PDE) in a calcium-dependent manner.
K A, Mereish +3 more
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Kohamamides A, B, and C, Cyclic Depsipeptides from an Okeania sp. Marine Cyanobacterium.
Journal of Natural Products, 2017Arihiro Iwasaki +5 more
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