Results 111 to 120 of about 497 (160)
Synthesis of the Segment of Natural Cyclic Depsipeptide Stereocalpin A
Chinese Journal of Applied Chemistry, 2010 openaire +1 more source
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Cyclic depsipeptides as potential cancer therapeutics
Anti-Cancer Drugs, 2015Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta Kitagaki, Shinya Murakami
exaly +3 more sources
Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetics
Organic Letters, 2014 A novel and highly efficient cyclization method has been developed to access a new class of cyclic carbo-isosteric depsipeptides and carbo-isosteric peptides. Our strategy requires easily accessible C-terminal methyl ketone ester or amide functionalized linear precursors as starting materials.
Stéphanie M, Guéret +2 more
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Cyclic Peptides and Depsipeptides from Fungi
2009This chapter describes the occurrence of cyclic peptides and cyclic depsipeptides within the kingdom Eumycota (true fungi), the diversity of structures and their chemical building blocks, their ecological roles and their different biological activities.
Heidrun Anke, Luis Antelo
exaly +2 more sources
Cyclic Depsipeptides, Ichthyopeptins A and B, from Microcystis ichthyoblabe
Journal of Natural Products, 2007 Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2).
Renate Mentel +2 more
exaly +2 more sources
Macrocyclization strategies for the total synthesis of cyclic depsipeptides
Organic & Biomolecular Chemistry, 2023Cyclic depsipeptides, bioactive natural products containing ester(s) and amides in the macrocycle, are synthesizedvia3 strategies, macrolactamization in solution, macrolactamization on-resin, and macrolactonization.
André R. Paquette, Christopher N. Boddy
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Controlling production of brominated cyclic depsipeptides by Pseudoalteromonas maricaloris KMM 636T
Letters in Applied Microbiology, 2005 Aims: This study aims at evaluating the impact of the nutrient medium components on the in vitro production of the cytotoxic alterochromides. Methods and Results: The employment matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS ...
M P Sobolevskaya +2 more
exaly +2 more sources
The Cyclic Depsipeptide Backbone of the Didemnins
Acta Crystallographica Section C Crystal Structure Communications, 1995An X-ray crystal analysis of phi-lactone N-¿1-¿N-¿4-¿[3- hydroxy-5-methyl-1-oxo-4-(N-L-threonylamino)heptyl]- oxy¿-2,5-dimethyl-1,3-dioxohexyl¿-L-leucyl¿-L-prolyl¿- N,O-dimethyl-L-tyrosine hydrobromide hydrate (1a), C42H66N5O11+.Br-.H2O, was obtained in order to determine the backbone folding of the macrocycle and to compare the results obtained with ...
S C, Mayer, P J, Carroll, M M, Joullié
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Total Synthesis of the Marine Cyclic Depsipeptide Viequeamide A
Journal of Natural Products, 2013The first total synthesis of viequeamide A, a natural cyclic depsipeptide isolated from a marine button cyanobacterium, was achieved with the N-Me-Val-Thr peptide bond as the final macrocyclization site. The synthetic product gave nearly identical spectroscopic data to that reported for the natural product.
Dongyu, Wang +5 more
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Total synthesis of aureobasidin a, an antifungal cyclic depsipeptide
Chemistry Letters, 1993Abstract A total synthesis of an antifungal cyclic depsipeptide aureobasidin A was first achieved mainly using PyBroP1) as a coupling reagent. The synthetic cyclized product was completely identical with the natural antibiotic in all respects. Some unexpected reactions due to N-methylamino acid were also described.
Toru Kurome +6 more
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