Results 91 to 100 of about 3,689 (198)

SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.

PLoS ONE, 2016
In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A).
Chelsi D Cassilly, Marcus M Maddox, Philip T Cherian, John J Bowling, Mark T Hamann, Richard E Lee, Todd B Reynolds   +6 more
doaj   +1 more source

High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
A Golden Gate Assembly (GGA)‐based method was developed for the efficient assembly of natural and engineered non‐ribosomal peptide synthetases (NRPS). This method has enabled the creation of NRPS libraries to generate novel peptides in high‐throughput as well as the targeted derivatisation of natural products (NPs).
Adrian Podolski, Timon A. Lindeboom, Leonard Präve, Maryam Dehghan, Hannah A. Minas, Janik Kranz, Daniel Schindler, Helge B. Bode   +7 more
wiley   +1 more source

Arthogalin, a Cyclic Depsipeptide from the Lichen Arthothelium galapagoense

Zeitschrift für Naturforschung B, 1995
The structure and stereochemistry of arthogalin from the liehen Arthothelium galapagoense has been elucidated as the cyclic depsipeptide 1′.
S. Huneck, U. Himmelreich, G. Nicholson
openaire   +1 more source

Plitidepsin Has a Safe Cardiac Profile: A Comprehensive Analysis

Marine Drugs, 2011
Plitidepsin is a cyclic depsipeptide of marine origin in clinical development in cancer patients. Previously, some depsipeptides have been linked to increased cardiac toxicity.
Carmen Kahatt, Cinthya Coronado, Pilar Lardelli, Claudia Silvia Corrado, Elena Roy, Vicente Alfaro, Bernardo Miguel-Lillo, Sonia Extremera, Arturo Soto-Matos, Sergio Szyldergemajn   +9 more
doaj   +1 more source

Cryptophycin unit B analogues

Beilstein Journal of Organic Chemistry
Drug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge.
Thomas Schachtsiek, Jona Voss, Maren Hamsen, Beate Neumann, Hans-Georg Stammler, Norbert Sewald   +5 more
doaj   +1 more source

Fluorescent Pseudomonas and cyclic lipopeptide diversity in the rhizosphere of cocoyam (Xanthosoma sagittifolium) [PDF]

, 2019
Cocoyam (Xanthosoma sagittifolium (L.)), an important tuber crop in the tropics, is severely affected by the cocoyam root rot disease (CRRD) caused by Pythium myriotylum. The white cocoyam genotype is very susceptible while the red cocoyam has some field
Adiobo, Amayana, Bertier, Lien, Geudens, Niels, Hua, Hoang Gia Khuong, Höfte, Monica, Martins, José, Omoboye, Olumide Owolabi, Oni, Feyisara Eyiwumi, Sinnaeve, Davy   +8 more
core   +2 more sources

Corals as Source of Bacteria with Antimicrobial Activity [PDF]

, 2008
In this study we examined marine bacteria associated with different corals (Porites lutea, Galaxea fascicularis, Acropora sp. and Pavona sp.) collected from vicinity of Panjang island, Jepara, North Java Sea, Indonesia for their antimicrobial activities ...
Imhoff, J. F. (Johannes), radjasa, O. (ocky), Sabdono, A. (Agus), Wiese, J. (Jutta)   +3 more
core  

Cyanotoxins: from poisoning to healing – A possible pathway? [PDF]

, 2015
[ENG] Cyanobacteria are photosynthetic microorganisms known for their multiple, and occasionally dual, ecologic roles. Cyanobacteria are major contributors to oxygen production on earth, but they often bloom in freshwater environments, depleting oxygen
Dias, Elsa, Paulino, Sérgio, Pereira, Paulo   +2 more
core  

Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge <i>Theonella swinhoei</i> That Inhibit Ras/Raf Interaction. [PDF]

J Nat Prod, 2020
Kim CK, Wang D, Bokesch HR, Fuller RW, Smith E, Henrich CJ, Durrant DE, Morrison DK, Bewley CA, Gustafson KR.   +9 more
europepmc   +1 more source

The role of the cyclic depsipeptide rings in antibiotics.

The Journal of Antibiotics, 1985
The physical and biological roles of the cyclic depsipeptides of actinomycin, quinomycin and triostin antibiotic families are proposed by examining the crystal structures of d(GC)-actinomycin D and d(CGTACG)-triostin A. The analyses suggest that not only are DNA-amino acid hydrogen-bonding and chromophore-base pair stacking crucially important for DNA ...
openaire   +3 more sources