Results 81 to 90 of about 1,254,991 (185)

Cyclic peptides and depsipeptides from cyanobacteria: A review

Journal of Industrial Microbiology, 1996
An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria). Several of these compounds possess structures that are similar to those of natural products from marine invertebrates.
openaire   +2 more sources

Histone Deacetylase Inhibitors (HDACis) as Latency-Reversing Agents in HIV Cure Strategies: Chemistry, Selectivity, and Clinical Perspective

Viruses
Latently infected resting CD4+ T cells represent the principal barrier to HIV eradication. Their immunological quiescence renders them invisible to combination antiretroviral therapy (cART) and host immune surveillance, sustaining a reservoir that ...
Hanan Almolhim
doaj   +1 more source

Two New Pentadepsipeptides from the Mangrove Fungus Aspergillus sp. SCSIO 41443

Metabolites
Background: Mangrove fungi are a prolific source of structurally diverse natural products. Among these, natural peptides with varied biological activities hold high commercial value and have been successfully developed into drugs for treating numerous ...
Ying Liu, Yi Chen, Jiao Xiao, Xin Sun, Xuefeng Zhou, Yonghong Liu, Bin Yang   +6 more
doaj   +1 more source

Turnagainolides A and B, Cyclic Depsipeptides Produced in Culture by a Bacillus sp.: Isolation, Structure Elucidation, and Synthesis

, 2016
Two new cyclic depsipeptides, turnagainolides A (1) and B (2), have been isolated from laboratory cultures of a marine isolate of Bacillus sp. The structures of 1 and 2, which are simply epimers at the site of macrolactonization, were elucidated by ...
Raymond J. Andersen (155984), Yonghong Zhang (20918), Dehai Li (1433623), Helen Bottriell (1490728), Alice L.-F. Mui (2196682), Ashraf Amlani (2196679), Gavin Carr (1278387), David E. Williams (155960)   +7 more
core   +1 more source

Macrocyclic Peptides: Chemistry and Biology of Stapled and Depsipeptides

, 2023
Macrocyclic peptides have been identified as key backbones in several biologically active compounds. They have been considered as great inspiration in the development of novel cyclic scaffolds in medicinal chemistry, notably in the introduction of α ...
Paquette, André
core   +1 more source

Cytotoxic Cyclic Depsipeptides from the Australian Marine Sponge Neamphius huxleyi

, 2016
Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MSn.
Dusan Zencak (134164), Ngoc B. Pham (1840516), Trong D. Tran (1562077), Gregory Fechner (1965394), Ronald J. Quinn (134169), Hoan T. Vu (2008690), John N. A. Hooper (154267)   +6 more
core   +1 more source

The role of the cyclic depsipeptide rings in antibiotics.

The Journal of Antibiotics, 1985
The physical and biological roles of the cyclic depsipeptides of actinomycin, quinomycin and triostin antibiotic families are proposed by examining the crystal structures of d(GC)-actinomycin D and d(CGTACG)-triostin A. The analyses suggest that not only are DNA-amino acid hydrogen-bonding and chromophore-base pair stacking crucially important for DNA ...
openaire   +3 more sources

Viequeamide A, a Cytotoxic Member of the Kulolide Superfamily of Cyclic Depsipeptides from a Marine Button Cyanobacterium

Journal of Natural Products, 2012
The viequeamides, a family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya) containing cyclic depsipeptides, were isolated from a shallow subtidal collection of a ‘button’ cyanobacterium (Rivularia sp.) from near the island of Vieques, Puerto Rico ...
Paul D. Boudreau, Tara Byrum, Wei-Ting Liu, P. Dorrestein, W. Gerwick   +4 more
semanticscholar   +1 more source

Design, synthesis, conformational and membrane ion transport studies of proline-adamantane hybrid cyclic depsipeptides

, 2008
The design, synthesis, conformational, crystallographic, and ion transport studies of 30-membered, proline containing depsipeptides that incorporate the rigid low molecular weight lipophilic adamantane (Adm) building blocks are reported.
Ranganathan, Darshan, Nagaraj, Ramakrishnan, Kumar, Mittapalli Gopi, Karle, Isabella L.   +3 more
core   +1 more source

Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis

, 2017
Seven cyclic depsipeptides were isolated from Hapsidospora irregularis and structurally characterized as the calcium channel blocker leualacin and six new analogues based on the NMR and HRESIMS data. These new compounds were named leualacins B–G.
Yong Zheng (420246), Yixing Qiu (3685225), Shing Wo Simon Sham (3685222), Fuchao Xu (1531672), Christopher A. Reilly (1957645), John G. Lamb (301106), Jixun Zhan (1319211), Wei Wang (17594), Zhenyu Lu (1531282), Thomas B. Kakule (3685219), Eric W. Schmidt (226940), Shuwei Zhang (610468), Lijiang Xuan (2437597)   +12 more
core   +1 more source