Results 81 to 90 of about 3,689 (198)

Characterization of the Ohmyungsamycin Biosynthetic Pathway and Generation of Derivatives with Improved Antituberculosis Activity

Biomolecules, 2019
The cyclic depsipeptides ohmyungsamycin (OMS) A (1) and B (2), isolated from the marine-derived Streptomyces sp. SNJ042, contain two non-proteinogenic amino acid residues, β-hydroxy-l-phenylalanine (β-hydroxy-l-Phe) and 4-methoxy-l-tryptophan ...
Eunji Kim, Yern-Hyerk Shin, Tae Ho Kim, Woong Sub Byun, Jinsheng Cui, Young Eun Du, Hyung-Ju Lim, Myoung Chong Song, An Sung Kwon, Sang Hyeon Kang, Jongheon Shin, Sang Kook Lee, Jichan Jang, Dong-Chan Oh, Yeo Joon Yoon   +14 more
doaj   +1 more source

Nonribosomal peptides, key biocontrol components for Pseudomonas fluorescens In5, isolated from a Greenlandic suppressive soil. [PDF]

, 2015
UnlabelledPotatoes are cultivated in southwest Greenland without the use of pesticides and with limited crop rotation. Despite the fact that plant-pathogenic fungi are present, no severe-disease outbreaks have yet been observed.
Dorrestein, Pieter C, Glaring, Mikkel A, Kersten, Roland, Koyama, Nobuhiro, Michelsen, Charlotte F, Stougaard, Peter, Watrous, Jeramie   +6 more
core  

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry. [PDF]

, 2016
Flow chemistry has been successfully integrated into the synthesis of a series of cyclooligomeric depsipeptides of three different ring sizes including the natural products beauvericin (1 a), bassianolide (2 b) and enniatin C (1 b).
Agarkov, Albericio, Amblard, Baumann, Baxendale, Carpino, Devos, Feifel, Fernández, Fosgerau, Ghosez, Hamill, Haveaux, Hu, Hu, Jestoi, Jones, Kanaoka, Kanaoka, Kanaoka, Kimmerlin, Kogan, Krause, Lee, Lee, Logrieco, Madry, Matthes, Merrifield, Mikhaleva, Newby, Newby, Nilanonta, Ovchinnikov, Ovchinnikov, Pattabiraman, Qian, Rodriguez, Saaby, Scherkenbeck, Sivanathan, Stockinger, Supothina, Suzuki, Süssmuth, Valera, Vlieghe, Xu, Zhan   +48 more
core   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

UZH: Alma Mater and Birthplace of Polyphor Ltd

CHIMIA, 2008
Daniel and Jean-Pierre Obrecht and Michael Altorfer present a brief account of the role that the Institute of Organic Chemistry, University of Zurich, has played in their scientific and professional development leading ultimately to a successful
Daniel Obrecht, Jean-Pierre Obrecht, Michael Altorfer   +2 more
doaj   +1 more source

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. [PDF]

, 2011
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides.
Bauman, Jonathan N, Gelev, Vladimir M, Jacobson, Matthew P, Kalgutkar, Amit S, Leung, Siegfried SF, Linington, Roger G, Liras, Spiros, Lokey, R Scott, Mathiowetz, Alan M, McEwen, Cayla M, Price, David A, Rand, Arthur C, Renzelman, Chad M, Rezai, Taha, Turner, Rushia A, White, Tina R, Zhang, Yizhong   +16 more
core   +1 more source

Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture [PDF]

, 2013
Peer reviewedPublisher ...
Abraham, Ando, Boot, Burgess, Cueto, Cui, Cui, Cámara, Fayos, Frey-Klett, Frisvad, Gibson, Gros, Hong, Jones, Kobayashi, Kronvall, Mansson, Nonaka, Nozawa, Oh, Oh, Okoro, Park, Pettit, Pettit, Rateb, Sanchez, Santhanam, Schroeckh, Seya, Shirling, Sonnenbichler, Wang, Watts, Xiang-qian, Yamazaki, Zhang, Zuck   +38 more
core   +1 more source

The V‐Shaped Hamilton Receptors: A Paradigmatic Multipurpose Scaffold

ChemistryOpen, Volume 15, Issue 1, January 2026.
This manuscript explores the historical context and significance of molecular recognition in relation to Hamilton‐type receptors. It concludes with a discussion on future prospects for the development of novel functionalized Hamilton‐type receptors. It is hoped that this collection will offer new insights and directions for the supramolecular chemistry
Shafieq Ahmad Wagay, Rashid Ali
wiley   +1 more source

Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D

Marine Drugs
Lagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from a marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and HCT116 colon cancer cells.
Huiru Nan, Xiong-En Long, Jianfei He, Hailiang Xing, Min-Jing Cheng, Jin-Bao Peng, Tao Ye, Jia-Lei Yan, Junyang Liu   +8 more
openaire   +3 more sources

Robust Synthesis of Prebiotic Precursors in Drying Reactions of Amino Acids and Keto Acids

ChemSystemsChem, Volume 8, Issue 1, January 2026.
Drying conditions drive reactions between amino acids and keto acids, generating a wide variety of small, reactive species, highlighting for the first time the potential significance of drying reactions in proto‐metabolism on early Earth. Condensation‐dehydration reactions are critical to both metabolism and polymerization in extant biology, and their ...
Eliav Marland, Gal Lipson, Rotem Edri, Or Cohen, Aikomari Guzman‐Martinez, Ori Shalev, César Menor Salvan, Moran Frenkel‐Pinter   +7 more
wiley   +1 more source