Results 61 to 70 of about 1,844 (163)

Histone Deacetylase Inhibitors (HDACis) as Latency-Reversing Agents in HIV Cure Strategies: Chemistry, Selectivity, and Clinical Perspective

Viruses
Latently infected resting CD4+ T cells represent the principal barrier to HIV eradication. Their immunological quiescence renders them invisible to combination antiretroviral therapy (cART) and host immune surveillance, sustaining a reservoir that ...
Hanan Almolhim
doaj   +1 more source

DeepHalo: Deep learning-powered exploration of halogenated metabolites uncovering antibacterial depsipeptides

Acta Pharmaceutica Sinica B
In the omics era, confident high-throughput analytical tools are crucial for the efficient identification of metabolites. Here, we present DeepHalo, a deep learning-integrated and hierarchically optimized workflow designed for high-throughput exploration
Shanshan Chang, Xin Qi, Mengyuan Wang, Xinyue Huang, Ning He, Mingxu Chen, Qing Lv, Jiahan Wang, Yu Du, Shuchen Wang, Yihong Li, Quanxiu Gao, Xinran Chen, Xingxing Li, Bin Hong, Yunying Xie   +15 more
doaj   +1 more source

The role of the cyclic depsipeptide rings in antibiotics.

The Journal of Antibiotics, 1985
The physical and biological roles of the cyclic depsipeptides of actinomycin, quinomycin and triostin antibiotic families are proposed by examining the crystal structures of d(GC)-actinomycin D and d(CGTACG)-triostin A. The analyses suggest that not only are DNA-amino acid hydrogen-bonding and chromophore-base pair stacking crucially important for DNA ...
openaire   +3 more sources

Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge <i>Theonella swinhoei</i> That Inhibit Ras/Raf Interaction. [PDF]

J Nat Prod, 2020
Kim CK, Wang D, Bokesch HR, Fuller RW, Smith E, Henrich CJ, Durrant DE, Morrison DK, Bewley CA, Gustafson KR.   +9 more
europepmc   +1 more source

Marine Tunicate, the Electuary of Mithridates

Iranian South Medical Journal, 2015
Tunicates are a large group of marine animals and have been named “tunicate” because of cellosic outer covering called a tunic. They are divided into four major classes of the ascidians, thaliaceans, appendicularians and Sorberacea. Ascidians
Gholam hosean Mohebbi, Saeadh samira Arshadi, Iraj Nabipour, Khalil Pourkhalili   +3 more
doaj  

Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis. [PDF]

J Nat Prod, 2017
Zhang S, Qiu Y, Kakule TB, Lu Z, Xu F, Lamb JG, Reilly CA, Zheng Y, Sham SW, Wang W, Xuan L, Schmidt EW, Zhan J.   +12 more
europepmc   +1 more source

Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D

Marine Drugs
Lagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from a marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and HCT116 colon cancer cells.
Huiru Nan, Xiong-En Long, Jianfei He, Hailiang Xing, Min-Jing Cheng, Jin-Bao Peng, Tao Ye, Jia-Lei Yan, Junyang Liu   +8 more
openaire   +3 more sources

Adsorption of cyclic depsipeptide mycotoxins to glass

, 2014
During analytical processes, adsorption of peptides, which is believed to mostly be due to non-covalent interactions and depending upon the experimental conditions, cannot only lead to significant loss of the analyte, but also to increased analytical variability. This undesirable aspect, however, has been given scant attention [1-2].
Taevernier, Lien, Vansteelandt, Stijn, De Spiegeleer, Bart   +2 more
openaire   +1 more source

Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. [PDF]

Org Lett, 2017
Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy J.   +9 more
europepmc   +1 more source

Total Synthesis of the Cyclic Depsipeptide Leualacin [PDF]

The Journal of Organic Chemistry, 1995
openaire   +2 more sources