Results 61 to 70 of about 3,689 (198)

Controlling production of brominated cyclic depsipeptides by Pseudoalteromonas maricaloris KMM 636T [PDF]

Letters in Applied Microbiology, 2005
This study aims at evaluating the impact of the nutrient medium components on the in vitro production of the cytotoxic alterochromides.The employment matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) facilitated the identification of a range of brominated cyclic depsipeptides with molecular masses of 843/845, 857/859 and 922/924 ...
Sobolevskaya, M. P., Smetanina, O. F., Speitling, M., Shevchenko, L. S., Dmitrenok, P. S., Laatsch, H., Kuznetsova, T. A., Ivanova, E., Elyakov, G. B.   +8 more
openaire   +4 more sources

Prva potpuna sinteza i biološko vrednovanje himenamida E [PDF]

, 2006
A new potent bioactive, proline-rich cyclic heptapeptide hymenamide E (13) was synthesized using the solution phase technique by cyclization of the linear peptide Boc-Phe-Pro-Thr-Thr-Pro-Tyr-Phe-OMe (12) after proper deprotection at carboxyl and amino ...
DEVENDER PATHAK, M. HIMAJA, RAJIV DAHIYA, SUNITA BHATT   +3 more
core   +1 more source

Solonamide B Inhibits Quorum Sensing and Reduces Staphylococcus aureus Mediated Killing of Human Neutrophils [PDF]

, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a serious human pathogen, and particularly the spread of community associated (CA)-MRSA strains such as USA300 is a concern, as these strains can cause severe infections in otherwise ...
A Nielsen, AE Clatworthy, AI Hidron, Anita Nielsen, AW Bernheimer, B Amulic, BA Diep, BC Herold, BE Ragle, DA Rasko, Dorte Frees, E Geisinger, EA George, FD Lowy, FD Lowy, G Ji, G Ji, G Sakoulas, G Werner, GJ Lyon, GJ Lyon, GJ Moran, GL Archer, Gunnar F. Kaufmann, GW Krucke, GY Cheung, Hanne Frøkiær, Hanne Ingmer, J Bubeck Wardenburg, JA Loughman, L Cegelski, L Jelsbak, Lone Gram, M Hentzer, M Mansson, M Otto, M Shoham, Maria Månsson, Martin S. Bojer, N Firon, P Mayville, P Recsei, PF Chan, R Wang, Richard P. Novick, RL Thompson, RO Jensen, RP Novick, RP Novick, RP Novick, S Bhakdi, S Bhakdi, S Deresinski, S Jarraud, SF Graves, SV Kazakova, SY Queck, Thomas O. Larsen, TM Jarry, WC Chan   +59 more
core   +2 more sources

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

Advanced Science, Volume 13, Issue 25, 4 May 2026.
In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun, Ruixiang You, Yiwen Zhou, Huiyan He, Wenfang Wang, Xudong Qu, Yinhua Lu, Lei Li   +7 more
wiley   +1 more source

Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioactives [PDF]

, 2014
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).Abstract: Marine sponges belonging to the phylum Porifera (Metazoa ...
Franco, Christopher Milton, Lei, Jie, Mehbub, Mohammad Ferdous, Zhang, Wei   +3 more
core   +2 more sources

Cyclic Peptide Conformational Landscapes Through the Lens of Mass Spectrometry and Orthogonal Spectroscopy

Journal of Mass Spectrometry, Volume 61, Issue 5, May 2026.
ABSTRACT Cyclic peptides occupy a structurally dynamic region of chemical space, where function often arises from ensembles rather than a single dominant fold. Closed backbones, frequent N‐methylation, heteroatoms, unnatural amino acids, and a strong propensity for metal coordination create dense conformational and coordination landscapes that ...
Emmanuel Nkyaagye, Happy Abena Safoah, Thanh D. Do   +2 more
wiley   +1 more source

Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative

European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.
The synthesis of a methylene‐linked acyldepsipeptide (ADEP) is reported. Success relied upon an improve method to generate a versatile vinyl glycine methyl ester synthon and a rationally optimized Grubb’s metathesis. NMR and in silico studies revealed an unusual trans–trans proline orientation for this new unnatural ADEP analog, advancing the ...
Katelyn G. Stevens-Davis, Xiaozheng Dou, Bo Hu, Yangxiong Li, Jiayuan Miao, Yu-Shan Lin, Adam S. Duerfeldt   +6 more
wiley   +1 more source

Characterizing the Anti-HIV Activity of Papuamide A

Marine Drugs, 2008
Papuamide A is representative of a class of marine derived cyclic depsipeptides, reported to have cytoprotective activity against HIV-1 in vitro. We show here that papuamide A acts as an entry inhibitor, preventing human immunodeficiency virus infection ...
Louis R. Barrows, Vicente Planelles, Cynthia D. Andjelic   +2 more
doaj   +1 more source

Prebiotic Organic Chemistry of Diketopiperazines

Asian Journal of Organic Chemistry, Volume 15, Issue 4, April 2026.
Diketopiperazines (DKPs) are considered essential in many life forms, but their prebiotic importance has not been fully understood. This review aims to discuss prebiotic organic chemistry for experimentally and computationally simulated reactions involving DKPs. ABSTRACT Even though the significance of amino acids and polypeptides is well recognized in
Jun Ohata
wiley   +1 more source

Detection of inhibitors of Candida albicans Cdr transporters using a diS-C3(3) fluorescence [PDF]

, 2015
Candida albicans is a major cause of opportunistic and life-threatening, systemic fungal infections. Hence new antifungal agents, as well as new methods to treat fungal infections, are still needed.
Anna Krasowska, Joanna Szczepaniak, Marcin Łukaszewicz   +2 more
core   +3 more sources