Results 41 to 50 of about 1,844 (163)
Investigation of the N-Terminus Amino Function of Arg10-Teixobactin
Molecules, 2017 Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis.
Shimaa A. H. Abdel Monaim +5 more
doaj +1 more source
Advances in large DNA fragment assembly for microbial cell factory engineering
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang +5 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.A stiff‐stilbene‐based transmembrane anion transporter is isomerized by energy transfer from a ruthenium tris(bipyridyl) photosensitizer in the lipid bilayer. This sensitized isomerization allows activation of chloride transport using visible instead of UV light, without the need to chemically modify the stiff‐stilbene photoswitch.
Julia Villalva +6 more
wiley +2 more sources
Actinomycin Derivatives: Structural Diversification and Biological Activities
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, Volume 13, Issue 38, 9 July 2026.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
From Prebiotic Catalysts to Modern Applications: How Early Catalysts Inspire Today's Innovations
Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.Simple catalytic systems that may have operated under prebiotic conditions offer useful molecular principles for the design of modern functional materials. By examining how amino acids, peptide assemblies, and metal complexes achieve catalysis through simple chemical features, this review highlights how prebiotic chemistry can inspire new strategies ...
Omer Agazani, Meital Reches
wiley +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Characterizing the Anti-HIV Activity of Papuamide A
Marine Drugs, 2008 Papuamide A is representative of a class of marine derived cyclic depsipeptides, reported to have cytoprotective activity against HIV-1 in vitro. We show here that papuamide A acts as an entry inhibitor, preventing human immunodeficiency virus infection ...
Louis R. Barrows +2 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.An Epicoccum fungus was isolated from gut of larvae of the butterfly Dione juno juno that feeds intensively on leaves of Passifloras. This fungus produces hydroxyanthraquinones that moderately inhibits growth of some Bacillus that coexist with the fungus in the insect gut, suggesting that it is probably important for microbial embalance in gut flora ...
Jessica Teixeira Dias +5 more
wiley +1 more source
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source