Results 31 to 40 of about 497 (160)
Marine Drugs, 2009 Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8–10 (1–3).
Hendrik Luesch +3 more
doaj +1 more source
Synthesis of 16-membered cyclic depsipeptides via direct amide cyclization
, 2000 The 2,2-disubstituted 2H-azirin-3-amines 5 (3-amino-2H-azirines) were used as synthons for alpha,alpha-disubstituted alpha-amino acids in the preparation of 16-membered cyclic depsipeptides 13.
Linden, Anthony; https://orcid.org/ +25 more
core +1 more source
Synthesis of cyclic depsipeptides and peptides via direct amide cyclization
, 1997 The 2,2-disubstituted 2H-azirin-3-amines 7 (2,2-disubstituted 3-amino-2H-azirines) were used as amino-acid synthons in the preparation of medium-sized cyclic depsipeptides and peptides derived from salicylic acids 6 and anthranilic acid 19, respectively (
Heimgartner, Heinz, Villalgordo, Jose M
core +1 more source
Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.A stiff‐stilbene‐based transmembrane anion transporter is isomerized by energy transfer from a ruthenium tris(bipyridyl) photosensitizer in the lipid bilayer. This sensitized isomerization allows activation of chloride transport using visible instead of UV light, without the need to chemically modify the stiff‐stilbene photoswitch.
Julia Villalva +6 more
wiley +2 more sources
Inhibition of Topoisomerase II by a Novel Antitumor Cyclic Depsipeptide, BE‐22179 [PDF]
Japanese Journal of Cancer Research, 1994 BE‐22179, a novel cyclic depsipeptide antibiotic having two 3‐hydroxyquinoline moieties, inhibited the DNA‐relaxing activity of L1210 topoisomerase II completely at 0.08 μM. This effect was far stronger than that of VP‐16. However, it did not show any marked effect on topoisomerase II‐mediated DNA cleavage.
Yoshinari, Tomoko +6 more
openaire +2 more sources
Dudawalamides A−D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens [PDF]
, 2017 HPLC. DudA family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A−D (1−4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and ...
Gerwick, William H. +11 more
core +1 more source
Marine Drugs, 2015 Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were ...
Munhyung Bae +4 more
doaj +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A
Marine Drugs, 2018 Our understanding of autophagy and lysosomal function has been greatly enhanced by the discovery of natural product structures that can serve as chemical probes to reveal new patterns of signal transduction in cells.
Xuemei Wan +6 more
doaj +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source