Results 11 to 20 of about 497 (160)

Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides

open access: yesMolecules, 2018
Cyclic peptoids have recently emerged as an important class of bioactive scaffolds with unique conformational properties and excellent metabolic stabilities.
Assunta D’Amato   +5 more
doaj   +2 more sources

mMass as a software tool for the annotation of cyclic peptide tandem mass spectra. [PDF]

open access: yesPLoS ONE, 2012
Natural or synthetic cyclic peptides often possess pronounced bioactivity. Their mass spectrometric characterization is difficult due to the predominant occurrence of non-proteinogenic monomers and the complex fragmentation patterns observed. Even though
Timo H J Niedermeyer, Martin Strohalm
doaj   +1 more source

Bright Side of Fusarium oxysporum: Secondary Metabolites Bioactivities and Industrial Relevance in Biotechnology and Nanotechnology

open access: yesJournal of Fungi, 2021
Fungi have been assured to be one of the wealthiest pools of bio-metabolites with remarkable potential for discovering new drugs. The pathogenic fungi, Fusarium oxysporum affects many valuable trees and crops all over the world, producing wilt.
Sabrin R. M. Ibrahim   +4 more
doaj   +1 more source

Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata

open access: yesMetabolites, 2022
Stereocalpin B, a new cyclic depsipeptide (1), and a new dibenzofuran derivative (3), were isolated from the Antarctic lichen, Ramalina terebrata (Ramalinaceae), along with a known cyclic depsipeptide (2).
Seulah Lee   +9 more
doaj   +1 more source

Virtual Prospection of Marine Cyclopeptides as Therapeutics by Means of Conceptual DFT and Computational ADMET

open access: yesPharmaceuticals, 2022
Bioactive peptides are chemical compounds created through the covalent bonding of amino acids, known as amide or peptide bonds. Due to their unusual chemistry and various biological effects, marine bioactive peptides have garnered considerable research ...
Norma Flores-Holguín   +2 more
doaj   +1 more source

Synthesis of cyclic depsipeptides under direct amide cyclization conditions [PDF]

open access: yes, 2005
This work describes the use of the "direct amide cyclization" (DAC) of dipeptides which contain β-, γ-, or δ-hydroxy acids, obtained by the reaction of the corresponding hydroxy acids with 3-amino-2H-azirines, the so-called "azirine/oxazolone" method ...
Iliev, Boyan Iliev
core   +1 more source

Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

open access: yesMarine Drugs, 2021
The genus Callyspongia (Callyspongiidae) encompasses a group of demosponges including 261 described species, of which approximately 180 have been accepted after taxonomic reviews.
Lucas Hilário Nogueira de Sousa   +4 more
doaj   +1 more source

Enhanced Ohmyungsamycin A Production via Adenylation Domain Engineering and Optimization of Culture Conditions

open access: yesFrontiers in Microbiology, 2021
Ohmyungsamycins (OMSs) A and B are cyclic depsipeptides produced by marine Streptomyces strains, which are synthesized by a non-ribosomal peptide synthetase. Notably, OMS A exhibits more potent activity against Mycobacterium tuberculosis and human cancer
Eunji Kim   +5 more
doaj   +1 more source

Two New Cyclic Depsipeptides from the Endophytic Fungus sp

open access: yesNatural Product Communications, 2015
Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal.
Fang Lv   +3 more
doaj   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

open access: yesAngewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham   +11 more
wiley   +2 more sources

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