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Chemical Classification of Cyclic Depsipeptides
Current Protein & Peptide Science, 2017 Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of
Taevernier, Lien +3 more
openaire +5 more sources
The mycotoxin definition reconsidered towards fungal cyclic depsipeptides
Journal of Environmental Science and Health, Part C, 2016 Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well?
Lien, Taevernier +4 more
openaire +4 more sources
Adsorption of cyclic depsipeptide mycotoxins to glass [PDF]
, 2014 During analytical processes, adsorption of peptides, which is believed to mostly be due to non-covalent interactions and depending upon the experimental conditions, cannot only lead to significant loss of the analyte, but also to increased analytical ...
De Spiegeleer, Bart +2 more
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Human skin kinetics of cyclic depsipeptide mycotoxins [PDF]
, 2014 Cyclic depsipeptides (CDPs) are an emerging group of naturally occurring bioactive peptides, some of which are already developed as pharmaceutical drugs, e.g. valinomycin. They are produced by bacteria, marine organisms and fungi [1].
De Spiegeleer, Bart +3 more
core +2 more sources
Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials
Molecules, 2023 Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition.
Plinio A. Trinidad-Calderón +2 more
doaj +1 more source
A Bidirectional Permeability Assay for beyond Rule of 5 Compounds
Pharmaceutics, 2021 Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involved ...
Yunhai Cui +6 more
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Total Synthesis of Pagoamide A
Molecules, 2021 The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous ...
Fusong Wu +4 more
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Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms
Marine Drugs, 2023 In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-
Wei Wang +7 more
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Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies
Marine Drugs, 2022 Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of ...
Ricardo Ribeiro +3 more
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Frontiers in Chemistry, 2020 Cyclic depsipeptides constitute a fascinating class of natural products. Most of them are characterized by an ester formed between the β-hydroxy function of Ser/Thr -and related amino acids- and the carboxylic group of the C-terminal amino acid.
Gerardo A. Acosta +14 more
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