Results 11 to 20 of about 1,254,991 (185)
Acta Pharmaceutica Sinica BIn the omics era, confident high-throughput analytical tools are crucial for the efficient identification of metabolites. Here, we present DeepHalo, a deep learning-integrated and hierarchically optimized workflow designed for high-throughput exploration
Shanshan Chang +15 more
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Total Syntheses of Colletopeptide A and Colletotrichamide A
Molecules, 2023 The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A, have been accomplished. The key advanced intermediate, a cyclic tridepsipeptide derivative, was constructed using a sequence of transformations that features ...
Jing Chen +4 more
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Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials
Molecules, 2023 Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition.
Plinio A. Trinidad-Calderón +2 more
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Total Synthesis of Pagoamide A
Molecules, 2021 The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous ...
Fusong Wu +4 more
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A Bidirectional Permeability Assay for beyond Rule of 5 Compounds
Pharmaceutics, 2021 Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involved ...
Yunhai Cui +6 more
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Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms
Marine Drugs, 2023 In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-
Wei Wang +7 more
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Marine Cyclic Peptides: Antimicrobial Activity and Synthetic Strategies
Marine Drugs, 2022 Oceans are a rich source of structurally unique bioactive compounds from the perspective of potential therapeutic agents. Marine peptides are a particularly interesting group of secondary metabolites because of their chemistry and wide range of ...
Ricardo Ribeiro +3 more
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Frontiers in Chemistry, 2020 Cyclic depsipeptides constitute a fascinating class of natural products. Most of them are characterized by an ester formed between the β-hydroxy function of Ser/Thr -and related amino acids- and the carboxylic group of the C-terminal amino acid.
Gerardo A. Acosta +14 more
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Synthesis of cyclic depsipeptides under direct amide cyclization conditions [PDF]
, 2005 This work describes the use of the "direct amide cyclization" (DAC) of dipeptides which contain β-, γ-, or δ-hydroxy acids, obtained by the reaction of the corresponding hydroxy acids with 3-amino-2H-azirines, the so-called "azirine/oxazolone" method ...
Iliev, Boyan Iliev
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mMass as a software tool for the annotation of cyclic peptide tandem mass spectra. [PDF]
PLoS ONE, 2012 Natural or synthetic cyclic peptides often possess pronounced bioactivity. Their mass spectrometric characterization is difficult due to the predominant occurrence of non-proteinogenic monomers and the complex fragmentation patterns observed. Even though
Timo H J Niedermeyer, Martin Strohalm
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