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Chemical Classification of Cyclic Depsipeptides

Current Protein and Peptide Science, 2017
Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of
Bart de Spiegeleer, Evelien Wynendaele
exaly   +6 more sources

The mycotoxin definition reconsidered towards fungal cyclic depsipeptides

Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews, 2016
Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well?
Bart de Spiegeleer, Lien Taevernier, Christian Burvenich   +2 more
exaly   +5 more sources

Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi

Molecules, 2018
Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the peptide structure.
Xiaohan Wang, Xiao Gong, Peng Li, Daowan Lai, Ligang Zhou   +4 more
doaj   +3 more sources

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides

BMC Biotechnology
Background The Arctic environment, characterized by extreme conditions, hosts a largely untapped reservoir of fungal communities that have adapted to these harsh conditions by producing specialized bioactive secondary metabolites. Among these, Acremonium
Sailesh Maharjan, Johan Isaksson, Teppo Rämä, Kine Østnes Hansen, Jeanette Hammer Andersen, Espen Holst Hansen   +5 more
doaj   +2 more sources

Two New Cyclic Depsipeptides from the Endophytic Fungus sp

Natural Product Communications, 2015
Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal.
Fang Lv, Georgios Daletos, Wenhan Lin, Peter Proksch   +3 more
doaj   +2 more sources

Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

European Journal of Medicinal Chemistry, 2018
G proteins are key mediators in the signaling of G protein-coupled receptors and involved in a plethora of important physiological processes. The natural product cyclic depsipeptides YM-254890 and FR900359 are the only known selective inhibitors of the ...
Xiao-Feng Xiong, Hans Brauner-Osborne, Michael Worch Boesgaard   +2 more
exaly   +2 more sources

ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A

Marine Drugs, 2018
Our understanding of autophagy and lysosomal function has been greatly enhanced by the discovery of natural product structures that can serve as chemical probes to reveal new patterns of signal transduction in cells.
Xuemei Wan, Jeffrey D. Serrill, Ian R. Humphreys, Michelle Tan, Kerry L. McPhail, Ian G. Ganley, Jane E. Ishmael   +6 more
doaj   +2 more sources

Biochemical Studies of the Lagunamides, Potent Cytotoxic Cyclic Depsipeptides from the Marine Cyanobacterium <em>Lyngbya majuscula</em>

Marine Drugs, 2012
Lagunamides A (<strong>1</strong>) and B (<strong>2</strong>) are potent cytotoxic cyclic depsipeptides isolated from the filamentous marine cyanobacterium, <em>Lyngbya majuscula</em>, from Pulau Hantu, Singapore ...
David Tai Leong, Lik Tong Tan, Ashootosh Tripathi, Wanru Fang   +3 more
doaj   +2 more sources

Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.

Marine Drugs, 2015
Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were ...
Munhyung Bae, Beomkoo Chung, Ki-Bong Oh, Jongheon Shin, Dong-Chan Oh   +4 more
doaj   +2 more sources

Trikoveramides A-C, cyclic depsipeptides from the marine cyanobacterium Symploca hydnoides

Phytochemistry, 2021
Lik Tong Tan
exaly   +2 more sources