Marine Organisms as a Prolific Source of Bioactive Depsipeptides [PDF]
Marine Drugs, 2023 Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and amino acids linked together by amide and ester bonds, have potential applications in agriculture and medicine.
Mingyuan Zeng +4 more
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Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials [PDF]
Molecules, 2023 Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition.
Plinio A. Trinidad-Calderón +2 more
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Cyanobacterial Peptides in Anticancer Therapy: A Comprehensive Review of Mechanisms, Clinical Advances, and Biotechnological Innovation [PDF]
Marine DrugsCyanobacteria-derived peptides represent a promising class of anticancer agents due to their structural diversity and potent bioactivity. They exert cytotoxic effects through mechanisms including microtubule disruption, histone deacetylase inhibition ...
Heayyean Lee +2 more
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Chemical Classification of Cyclic Depsipeptides
Current Protein and Peptide Science, 2017 Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of
Bart De Spiegeleer
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Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides [PDF]
BMC BiotechnologyBackground The Arctic environment, characterized by extreme conditions, hosts a largely untapped reservoir of fungal communities that have adapted to these harsh conditions by producing specialized bioactive secondary metabolites. Among these, Acremonium
Sailesh Maharjan +5 more
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Three New Depsipeptides, Homiamides A–C, Isolated from Streptomyces sp., ROA-065 [PDF]
MoleculesThree new depsipeptides, homiamides A–C (1–3), were isolated from a marine sediment-derived strain of Streptomyces sp., ROA-065. The planar structures of homiamides A–C (1–3) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance ...
Jeong-Hyeon Kim +8 more
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Cytotoxic and Antibacterial Cyclodepsipeptides from an Endophytic Fungus Fusarium avenaceum W8 [PDF]
MoleculesSeven cyclic depsipeptides, including two new cyclic pentadepsipeptides avenamides A (1) and B (2), were isolated from a plant-derived fungus Fusarium avenaceum W8 by using the bioassay-guided fractionation method.
Zimo Wang +5 more
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Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
Marine Drugs, 2021 Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines.
Synthia Michon +2 more
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Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms
Marine Drugs, 2023 In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-
Wei Wang +7 more
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Life, 2022 The origin of biopolymers is a central question in origins of life research. In extant life, proteins are coded linear polymers made of a fixed set of twenty alpha-L-amino acids.
Moran Frenkel-Pinter +6 more
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