Results 1 to 10 of about 9,955 (253)
Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum [PDF]
Beilstein Journal of Organic Chemistry, 2012 The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from
Friederike I Nollmann +2 more
exaly +3 more sources
Acta Pharmaceutica Sinica B, 2015 A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound.
Jingya Sun, Hongchun Liu, Jidong Wang
exaly +4 more sources
Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach
Organic Letters, 2022 Genome mining and bioinformatics analyses allowed us to rationally find a candidate biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium.
Taro Ozaki (823047) +11 more
core +2 more sources
Neoplasia: An International Journal for Oncology Research, 2009 Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor,
Yang Yang +11 more
doaj +2 more sources
On-resin multicomponent 1,3-dipolar cycloaddition of cyclopentanone–proline enamines and sulfonylazides as an efficient tool for the synthesis of amidino depsipeptide mimics [PDF]
Amino Acids, 2020 Depsipeptides are biologically active peptide derivatives that possess a high therapeutic interest. The development of depsipeptide mimics characterized by a chemical diversity could lead to compounds with enhanced features and activity. In this work, an
Pieraccini, Stefano +7 more
core +2 more sources
Journal of the American Chemical Society, 2021 The mechanism by which informational polymers first formed on the early earth is currently unknown. The RNA world hypothesis implies that RNA oligomers were produced prebiotically, before the emergence of enzymes, but the demonstration of such a process ...
Ramanarayanan Krishnamurthy +13 more
core +2 more sources
Total Synthesis of the Marine Cyclic Depsipeptide Lagunamide D [PDF]
Marine DrugsLagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from a marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and
Huiru Nan +8 more
doaj +2 more sources
European Journal of Organic Chemistry, 2020 An efficient and practical method for the synthesis of (9R,14R,17R)-FE399, a novel antitumor bicyclic depsipeptide, was developed. A 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dehydration condensation reaction was effectively employed for the ...
Takayuki Tonoi +2 more
exaly +2 more sources
Tetrahedron Letters, 2008 Factors that determine the chirality of supramolecular helical tapes formed by a backbone-modified amylin(20-29) depsipeptide and inverso-depsipeptide, were studied by Fourier transform infrared spectroscopy, circular dichroism and transmission electron ...
Ronald C Elgersma +2 more
exaly +3 more sources
Depsipeptide substrates for sortase-mediated N-terminal protein ligation [PDF]
Nature Protocols, 2014 Technologies that allow the efficient chemical modification of proteins under mild conditions are widely sought after. Sortase-mediated peptide ligation provides a strategy for modifying the N or C terminus of proteins. This protocol describes the use of
Michael E Webb +5 more
core +2 more sources