Results 11 to 20 of about 9,955 (253)

Transcription inhibition by the depsipeptide antibiotic salinamide A [PDF]

eLife, 2014
We report that bacterial RNA polymerase (RNAP) is the functional cellular target of the depsipeptide antibiotic salinamide A (Sal), and we report that Sal inhibits RNAP through a novel binding site and mechanism.
David Degen, Yu Feng, Yu Zhang, Katherine Y Ebright, Yon W Ebright, Matthew Gigliotti, Hanif Vahedian-Movahed, Sukhendu Mandal, Meliza Talaue, Nancy Connell, Eddy Arnold, William Fenical, Richard H Ebright   +12 more
doaj   +5 more sources

A Survey of Didemnin Depsipeptide Production in Tistrella [PDF]

Marine Drugs, 2023
As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs.
Robert J. Stankey, Don Johnson, Brendan M. Duggan, David A. Mead, James J. La Clair   +4 more
doaj   +4 more sources

SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.

PLoS ONE, 2016
In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A).
Chelsi D Cassilly, Marcus M Maddox, Philip T Cherian, John J Bowling, Mark T Hamann, Richard E Lee, Todd B Reynolds   +6 more
doaj   +2 more sources

Preclinical Assessment of a 68Ga-DOTA-Functionalized Depsipeptide as a Radiodiagnostic Infection Imaging Agent

Molecules, 2017
The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2)
Thomas Ebenhan, Botshelo Brenda Mokaleng, Jacobus Daniel Venter, Hendrik Gert Kruger, Jan Rijn Zeevaart, Mike Sathekge   +5 more
doaj   +2 more sources

Structure and Antibacterial Activity of Ambobactin, a New Telomycin-Like Cyclic Depsipeptide Antibiotic Produced by Streptomyces ambofaciens F3

Molecules, 2015
A new telomycin-like cyclic depsipeptide, ambobactin (1), was isolated from the metabolites of Streptomyces ambofaciens F3, an endophyte of Platycladus orientalis.
Shaopeng Wei, Wenhao Zhang, Zhiqin Ji
doaj   +2 more sources

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.

PLoS Pathogens, 2015
UnlabelledPharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection.
Ole S Søgaard, Mette E Graversen, Steffen Leth, Rikke Olesen, Christel R Brinkmann, Sara K Nissen, Anne Sofie Kjaer, Mariane H Schleimann, Paul W Denton, William J Hey-Cunningham, Kersten K Koelsch, Giuseppe Pantaleo, Kim Krogsgaard, Maja Sommerfelt, Remi Fromentin, Nicolas Chomont, Thomas A Rasmussen, Lars Østergaard, Martin Tolstrup   +18 more
doaj   +2 more sources

Multicomponent Synthesis of Cyclic Depsipeptide Mimics by Ugi Reaction Including Cyclic Hemiacetals Derived from Asymmetric Organocatalysis

Journal of Organic Chemistry, 2016
The synthesis of novel cyclic depsipeptide mimics by means of an organocatalytic conjugate addition, leading to chiral cyclic hemiacetals, followed by a multicomponent reaction with α-amino acids and isocyanides, is described. The initial organocatalytic
Odette Concepción (1392715), Márcio W. Paixão (1392730), Alexander F. de la Torre (1392727), Daniel G. Rivera (1392718), Arlene G. Correa (1392724), Radell Echemendia (1392721)   +5 more
core   +2 more sources

Biosynthesis of the 15-Membered Ring Depsipeptide Neoantimycin. [PDF]

ACS Chemical Biology, 2018
Antimycins are a family of natural products possessing outstanding biological activities and unique structures, which have intrigued chemists for over a half century.
Will Skyrud, Joyce Liu, D. Thankachan, M. Cabrera, R. Seipke, Wenjun Zhang   +5 more
semanticscholar   +4 more sources

A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

Beilstein Journal of Organic Chemistry, 2012
The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach.
James R Cochrane, Christopher S P Mcerlean, Katrina A Jolliffe   +2 more
exaly   +2 more sources

Rivastigmine-Loaded L-Lactide-Depsipeptide Polymeric Nanoparticles: Decisive Formulation Variable Optimization

Scientia Pharmaceutica, 2013
The main aim of the investigation was to explore a novel L-lactide-depsipeptide copolymer for the development of rivastigmine-loaded polymeric nanoparticles.
Pradeep VAVIA, Kunal PAGAR
core   +2 more sources