Results 11 to 20 of about 7,439 (222)
Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment [PDF]
Neoplasia: An International Journal for Oncology Research, 2009 Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor,
Yang Yang +11 more
doaj +2 more sources
Bioprospecting Indoor Bacteria Producing Bioactive Metabolites. [PDF]
Environ Microbiol RepThe indoor environments served as easily accessible habitats for bacteria producing mitochondrial toxins and ionophores, effects exhibited by known antiparasitic drugs and effects useful in mitochondrial research. This study describes the bacterial species and genera producing toxic peptide antibiotics and identifies some of their biological targets in
Andersson MA +4 more
europepmc +2 more sources
Total Synthesis of the Antitumor Depsipeptide FE399 and its S-Benzyl Derivative: A Macrolactamization Approach [PDF]
, 2020 An efficient and practical method for the synthesis of (9R,14R,17R)-FE399, a novel antitumor bicyclic depsipeptide, was developed. A 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dehydration condensation reaction was effectively employed for the ...
Isamu Shiina (8610042) +20 more
core +3 more sources
Marine Organisms as a Prolific Source of Bioactive Depsipeptides
Marine Drugs, 2023 Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and amino acids linked together by amide and ester bonds, have potential applications in agriculture and medicine.
Mingyuan Zeng +4 more
doaj +1 more source
A contribution to the nomenclature of depsipeptides [PDF]
Journal of Peptide Science, 2003 AbstractDepsipeptides, also called peptolides, are a class of peptidic compounds in which an amide bond has been replaced with an ester bond. The literature does not clearly display rules for the nomenclature of such compounds. Here a method is proposed to transcribe drawn depsipeptide structures in one‐line text.
Sorin V, Filip, Florine, Cavelier
openaire +2 more sources
A Survey of Didemnin Depsipeptide Production in Tistrella
Marine Drugs, 2023 As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs.
Robert J. Stankey +4 more
doaj +1 more source
Cyclic Thiosulfinates: Synthesis and Applications in Chemical Biology and Materials Science. [PDF]
ChembiochemCyclic thiosulfinates (CTs) are strained organosulfur heterocyclic compounds with a polarized ─S(═O)─S─ bond that enables selective thiol reactivity. Advances in synthesis afford tunable scaffolds that support efficient proximal thiol cross‐linking and enable applications in chemical biology and materials science. Cyclic thiosulfinates (CTs) constitute
Liebson B +3 more
europepmc +2 more sources
SynOpen, 2021 An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid +3 more
doaj +1 more source
Total Synthesis of Pagoamide A
Molecules, 2021 The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous ...
Fusong Wu +4 more
doaj +1 more source
Total Synthesis of the Antitumor Depsipeptide FR-901,228
, 2016 Total Synthesis of the Antitumor Depsipeptide FR-901 ...
Khan W. Li (2997414) +3 more
core +2 more sources