Results 21 to 30 of about 5,696 (181)
Marine Drugs, 2013 During our search for new natural products from the marine environment, we discovered a wide range of cyclic peptides from a marine Photobacterium, closely related to P. halotolerans.
Louise Kjaerulff +6 more
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A New Depsipeptide Antibiotic, Variapeptin [PDF]
Agricultural and Biological Chemistry, 1990 A culture similar to Streptomyces variabilis was found to produce a novel cyclic hexadepsipeptide antibiotic named variapeptin. Variapeptin is structurally related to azinothricin, A83586C, and citropeptin. The antibiotic was active against Gram-positive bacteria and showed cytotoxic activity against mammalian cells.
NAKAGAWA, Masaya +3 more
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Molecules, 2019 The first total syntheses of izenamides A, B, and C, which are depsipeptides inhibitor of cathepsin D, were accomplished. In addition, the stereochemistry of izenamide B was confirmed by our syntheses.
Changjin Lim
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Chemical Classification of Cyclic Depsipeptides
Current Protein & Peptide Science, 2017 Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of
Taevernier, Lien +3 more
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A new depsipeptide antibiotic, citropeptin. [PDF]
Agricultural and Biological Chemistry, 1990 An actinomycete identified as Streptomyces flavidovirens was found to produce a new cyclic hexadepsipeptide antibiotic, designated citropeptin. Citropeptin showed antitumor activity against P388 murine leukemia.
HAYAKAWA, Yoichi +3 more
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Biosynthetic Modularity Rules in the Bisintercalator Family of Antitumor Compounds
Marine Drugs, 2014 Diverse actinomycetes produce a family of structurally and biosynthetically related non-ribosomal peptide compounds which belong to the chromodepsipeptide family. These compounds act as bisintercalators into the DNA helix.
Javier Fernández +7 more
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Bouillonamide: A Mixed Polyketide–Peptide Cytotoxin from the Marine Cyanobacterium Moorea bouillonii
Marine Drugs, 2013 The tropical marine cyanobacterium, Moorea bouillonii, has gained recent attention as a rich source of bioactive natural products. Continued chemical investigation of this cyanobacterium, collected from New Britain, Papua New Guinea, yielded a novel ...
Lik Tong Tan +2 more
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Total synthesis and biological evaluation of fluorinated cryptophycins
Beilstein Journal of Organic Chemistry, 2012 Cryptophycins are cytotoxic natural products that exhibit considerable activities even against multi-drug-resistant tumor cell lines. As fluorinated pharmaceuticals have become more and more important during the past decades, fluorine-functionalized ...
Christine Weiß +3 more
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Marine Drugs, 2017 Bioassay-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the purification and structure characterization of two new hybrid polyketide-non-ribosomal peptide (PKS-NRPS) macrocyclic compounds, tricholides A and B
Matthew J. Bertin +7 more
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Effective Synthesis and Antifouling Activity of Dolastatin 16 Derivatives
Marine Drugs, 2022 Some derivatives of dolastatin 16, a depsipeptide natural product first obtained from the sea hare Dolabella auricularia, were synthesized through second-generation synthesis of two unusual amino acids, dolaphenvaline and dolamethylleuine.
Loida O. Casalme +8 more
doaj +1 more source