Results 21 to 30 of about 9,955 (253)
Total synthesis of the antifungal depsipeptide petriellin A
The Journal of Organic Chemistry, 2011 Publication Date (Web): July 8, 2011We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase
Sleebs, MM +14 more
core +4 more sources
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles
Nature Chemistry, 2022 The direct genetically encoded cell-based synthesis of non-natural peptide and depsipeptide macrocycles is an outstanding challenge. Here we programme the encoded synthesis of 25 diverse non-natural macrocyclic peptides, each containing two non-canonical
M. Spinck +6 more
semanticscholar +1 more source
JACS Au, 2022 The high kinetic barrier to amide bond formation has historically placed narrow constraints on its utility in reversible chemistry applications. Slow kinetics has limited the use of amides for the generation of diverse combinatorial libraries and ...
M. C +11 more
semanticscholar +1 more source
Morinagadepsin, a Depsipeptide from the Fungus Morinagamyces vermicularis gen. et comb. nov.
Microorganisms, 2021 The new genus Morinagamyces is introduced herein to accommodate the fungus Apiosordaria vermicularis as inferred from a phylogenetic study based on sequences of the internal transcribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and ...
Karen Harms +4 more
doaj +1 more source
Nature Communications, 2021 FR900359 (FR) is a Gq protein inhibitor depsipeptide isolated from an uncultivable plant endosymbiont and synthesized by non-ribosomal peptide synthetases.
Cornelia Hermes +17 more
doaj +1 more source
Marine Drugs, 2021 Marine actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the marine-derived Streptomyces sp.
Zhikai Guo +6 more
doaj +1 more source
Acyl depsipeptide (ADEP) resistance in Streptomyces
Microbiology, 2011 ADEP, a molecule of the acyl depsipeptide family, has an antibiotic activity with a unique mode of action. ADEP binding to the ubiquitous protease ClpP alters the structure of the enzyme.
Philippe Mazodier +2 more
core +3 more sources
Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
RSC Advances, 2021 Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages.
Moran Frenkel-Pinter +4 more
semanticscholar +1 more source
Marine Organisms as a Prolific Source of Bioactive Depsipeptides
Marine Drugs, 2023 Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and amino acids linked together by amide and ester bonds, have potential applications in agriculture and medicine.
Mingyuan Zeng +4 more
doaj +1 more source
Frontiers in Catalysis, 2023 In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho +28 more
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